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School of Pharmacy Division of Pharmacognosy

Marc Slattery

Photo of Dr. Slattery

Professor of Pharmacognosy
Research Professor in the Research Institute of Pharmaceutical Sciences

Dr. Slattery received his B.S. degree in Biology from Loyola Marymount University in 1981. He completed his M.A. in Marine Biology from San Jose State University at the Moss Landing Marine Laboratories in 1987, and worked for the next two years as the project manager for the Aquatic Toxicology division of EA Engineering, Science, & Technology (Lafayette, CA). In 1994 he received his Ph.D. in Biology from the University of Alabama at Birmingham for chemical ecology research conducted in Antarctica. Dr. Slattery was awarded an NSF Marine Biotechnology Fellowship in 1994 to continue his research on the tropical Pacific reef systems at the University of Guam. He was appointed Director of the NOAA NIUST Ocean Biotechnology Center in 2001, and Professor of Pharmacognosy and Research Professor of RIPS at The University of Mississippi in 2008.
email: slattery@olemiss.edu

Click here to see Research in Progress and Publications

  • Research in Progress

  • Dr. Slattery's research interests include chemical ecology and environmental toxicology of marine and freshwater bacteria, algae, and invertebrates. Specifically, the lab is focused on natural and anthropogenic stressors and their impact on the ecology (e.g., defense and reproduction) and the physiology (e.g., metabolic endpoints) of indicator species. Recently this work has included hybrid soft corals in the Indo-Pacific, and sponges from deep reefs and marine caves collected using technical diving methods. Chemical ecology is a rapidly expanding interdisciplinary field (due in part to the pharmaceutical and biotechnological applications of this research) focused on the ecological roles of the myriad chemical compounds produced by various organisms. Aquatic habitats (marine and freshwater) account for over 75% of the surface area of the planet and provide diverse ecosystems that can be mediated by chemical signals. For instance, predator-prey interactions, competition, symbioses, reproduction, and larval settling cues often involve novel functionalized metabolites and highly specific target receptor systems. In understanding the ecophysiological factors which effect production of these bioactive compounds, and the costs imposed, we can determine the best ways to assure availability of novel natural products that might prove valuable as biotechnology products (e.g., drugs from the sea).

    Dr. Slattery is the Research Coordinator for the Environmental Toxicology Research Program at the University of Mississippi. His work on environmental stressors is primarily aimed at the organismal-, population- and community-level effects, and has addressed: the impacts of Hurricane Katrina on seagrass communities along the northern Gulf of Mexico coastline, the consequences of oil spills in Alaska and the GOM, the effects of wastewater discharge into San Francisco Bay and pesticide run-off into Mississippi wetlands, and the results of disease, invasive species, and thermal stress on coral reefs. Recent work is focused on the effects of an emerging environmental stressor, ocean acidification, on corals and sponges using proteomic applications in order to identify specific resistance pathways.

  • Representative Publications & Presentations

  • Chemical Ecology

    Slattery M, DJ Gochfeld (in press) Chemical Interactions among Marine Competitors, and Host-Pathogens. Marine Natural Products Science: A Reference Book. Springer, New York.

    Slattery M, HN Kamel, S Ankisetty, DJ Gochfeld, CA Hoover, RW Thacker (2008) Hybrid vigor in a tropical Pacific soft coral community. Ecol Monogr 78:423-443

    Frankfater CR, MR Tellez, M Slattery (2009) The scent of alarm: ontogenetic and genetic variation in the osmeterial gland chemistry of Papilio glaucus caterpillars. Chemoecology 19:81-96

    Slattery M, VJ Paul (2008) Indirect effects of bleaching on predator deterrence in the tropical Pacific soft coral Sinularia maxima. Mar Ecol Prog Ser 354:169-179

    Hoover CA, M Slattery, NM Targett, AG Marsh (2008) Transcriptome and metabolite responses to predation in a south Pacific soft coral. Bio Bull 214:319-328

    DeBusk BC, M Slattery, JS Ki, JS Lee, R Aparicio-Fabre, D Schlenk (2008) Species differences and effects of soft coral extracts from Sinularia maxima on the expression of cytochrome P4501A and 2N in butterflyfishes (Chaetodon spp.). Fish Physio Biochem 34:483-492

    Hoover CA, M Slattery, AG Marsh (2007) Gene expression profiling of two related soft corals, Sinularia polydactyla and S. maxima, and their putative hybrid at different life-history stages. Comp Biochem Physiol Part D 2:135-143

    Deep Reefs

    Slattery M, MP Lesser, D Brazeau, MD Stokes, JJ Leichter (accepted) Connectivity and stability of mesophotic coral reefs. Journal of Experimental Marine Biology & Ecology

    Lesser MP, M Slattery (in review) Invasive lionfish causes a phase shift to algal dominated communities at mesophotic depths on a Bahamian coral reef. Mar Ecol Prog Ser

    Lesser MP, M Slattery, M Stat, M Ojimi, R Gates, A Grottoli (2010) Photoacclimatization by the coral Montastraea cavernosa in the mesophotic zone: Light, food, and genetics. Ecology 91:990-1003

    Lesser MP, M Slattery, JJ Leichter (2009) Ecology of mesophotic coral reefs. J Exp Mar Biol Ecol 375:1-8

    Environmental Toxicology.

    Slattery M, KL Willett, GP Cobb, WH Benson (2010) Multiple facets of environmental impacts from Hurricane Katrina. Env Tox Chem 29:1401-1402.

    Slattery M, MP Lesser. Ocean Exploration: Consequences of lionfish invasion to stability of mesophotic coral reefs. Ocean Sciences Meeting, Portland OR, 22-26 March 2010 [invited talk].

    Krentz L, KE Marsh, DJ Gochfeld, KL Willett, M Slattery. Effects of BaP, EE2 and a mixture of the two on the sex change event in the hermaphroditic Bridled Goby, Coryphopterus glaucofraenum. 30th Annual Meeting of SETAC, New Orleans LA, 19-23 November 2009

    Slattery M, KL Willett, DJ Gochfeld, J Weston, C Warren, C Easson, G Easson, J Janaskie, A Boettcher, B Ehmen, CA May. Impacts of Hurricane Katrina on seagrass beds in Grand Bay, Mississippi. 29th Annual Meeting of SETAC, Tampa FL, 17-21 November 2008

    Olson JB, DJ Gochfeld, M Slattery (2006) Aplysina red band syndrome: a new threat to Caribbean sponges. Dis Aquat Org 71:163-168

    Gochfeld DJ, JB Olson, M Slattery (2006) Colony versus population variation in susceptibility and resistance to Dark Spot Syndrome in the Caribbean coral Siderastrea siderea. Dis Aquat Org 69:53-65

    Foran CM, J Weston, M Slattery, BW Brooks, DB Huggett (2004) Reproductive assessment of Japanese medaka (Oryzias latipes) following a four week Fluoxetine (SSRI) exposure. Arch Env Cont Tox 46:511-517

    Natural Products

    Ankisetty S, DJ Gochfeld, MC Diaz, SI Khan, M Slattery (accepted) Chemical constituents of the deep reef Caribbean sponges Plakortis angulospiculatus and Plakortis halichondroides and their antiinflamatory activities. Journal of Natural Products.

    Kamel HN, YB Kim, JM Rimoldi, FR Fronczek, D Ferreira, M Slattery. (2009) Scalarane sesterterpenoids: semisynthesis and biological activity. J Nat Prods 72:1492-1496.

    Kamel HN, Y Ding, XC Li, D Ferreira, FR. Fronczek, M. Slattery (2009) Beyond polymaxenolide: New cembrane-africanene terpenoids from the hybrid soft coral Sinularia maxima x S. polydactyla. J Nat Prods 72:900-905

    Ankisetty S, M Kelly, M Slattery (2007) Alkaloids from an undescribed Thorectid sponge (Porifera: Dictyoceratida) from the Northern Marianas. Nat Prod Comm 2:1145-1148

    Kamel HN, FR Fronczek, SI Khalifa, M Slattery (2007) Microbial transformation of 5-Episinuleptolide. Chem Pharm Bull 55:537-540

    Slattery M. Marine natural products: Data mining in the NIUST OBCR repository. Indo-US Conference on New Bioactive Molecules in Pharmaceutical Research- Contribution of Natural Products, Hyderabad India, 13-14 November 2006 [invited plenary]

    Nagle D, AM Clark, M Slattery (2003) Chemical ecology and natural products from wetlands. In: MM Holland, E Blood, LR Schaffer (eds), Sustainability of Wetlands and Water Resources. Island Press, Covela CA, pp 157-169