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School of Pharmacy Department of Pharmacognosy

Samir A. Ross

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Professor of Pharmacognosy
Research Professor in the Research Institute of Pharmaceutical Sciences

Dr. Ross received his B.S. degree in Pharmacy (1966), Diploma in hospital pharmacy (1967) and M.S. in Pharmacognosy (1970) from the School of Pharmacy, Assiut University, Assiut Egypt. He received his Ph.D. in Pharmacognosy and Chemistry of natural products (1976) from the Medical Institute in Kiev, Ukraine (former Soviet Union). He joined the School of Pharmacy, Assiut University, Assiut, Egypt in 1967 as an instructor until 1972. In 1976 he was appointed as an assistant professor at the same school promoted then to associate professor: (1980) and to Professor of Phytochemistry and Pharmacognosy in the same school in 1984. In 1979 he traveled to London University, School of Pharmacy (Chelsea College) and taught for six months. In 1984 he came to the United States of America on a Peace Fellowship for one year and worked with Professor Maurice Shamma at the University of Pennsylvania in the area of isoquinoline alkaloids. In 1986 he came again to the USA for two years to work with Professor S. W. Pelletier at the University of Georgia as a visiting professor in the area of diterpenoid alkaloids. In 1990 he returned to the USA to join Professor S.W.Pelletier for two years, then he joined the University of Mississippi in 1992 to work in the area of drugs of abuse with Professor Mahmoud A. ElSohly. He became research assistant professor in the Research Institute of Pharmaceutical Sciences and Assistant Professor of Pharmacognosy in 1995. Finally he was promoted to research Associate professor in the Research Institute of Pharmaceutical sciences and Associate professor of Pharmacognosy in 2000. In July of 2009 he was appointed as a Professor of Pharmacognosy and as a Research Professor in the Research Institute of Pharmaceutical Sciences.

email: sross@olemiss.edu

Click here to see Research in Progress and Publications

  • Research in Progress

  • Dr. Ross's research interests include the isolation and structure elucidation of biologically active natural products from both higher plants and fungi especially alkaloids, flavonoids, steroids, triterpenes, and cannabinoids. Also his research interest include analytical method development of these compounds by HPLC, GC and GC/MS. Dr. Ross is heavily involved in research in the areas of drug abuse and in drug discovery and development.

  • Representative Publications

  • El-Alfy, AT, Ivey, K., Robinson, K., Ahmed, S., Radwan, M., Slade, D., Khan, I., ElSohly, MA, and Ross, SA., Antidepressant-like effect of Δ9-tetrahydrocannabinol and other Cannabinoids isolated from Cannabis sativa L., Pharmacology, Biochemistry and Behavior, 95, 434–442 (2010).

    Ibrahim, AB., Radwan, M., Ahmed, S., Slade, D., Ross, SA., ElSohly, MA., Khan, I., Microbial metabolism of cannflavin A and B isolated from Cannabis sativa, Phytochemistry , 71, 1014–1019 (2010).

    Radwan, MM., ElSohly, M., Slade, D., Ahmed, SA., Ross, SA.*, Biologically Active Cannabinoids from from High Potency Cannabis sativa,  J. Nat. Prod. , 72, 906-911 (2009).

    Stanikunaite, R., Khan, SI., Trappe, JM., and Ross, SA.*, Cyclooxygenase-2-inhibitory and Antioxidant Compounds from the truffle Elaphyomyces granulatus, Phytotherapy Research, 23, 575-578 (2009).

    Galal, MA., Gul, W., Slade, D., Ross, SA., Feng, S., Hollingshead, MG., Alley, MC., Kaur, G., ElSohly,   MA., Synthesis and Evaluation of Dihydroartemisinin and Dihydroartemisitene Acetal dimmers showing anticancer and antiprotozoal activity, Bioorganic & Medicinal Chemistry 17 741–751,(2009).

    Ross, SA*, Guzman, RR, Radwan, MM, Jacob, M, Ding, Y, Li, XC, Ferreira, D, and Manly, SP,  Sorocenols G and H, Anti-MRSA Oxygen Heterocyclic Diels-Alder-Type Adducts from Sorocea muriculata Roots, J. Nat. Prod. , 71 (10), 1764-1767 (2008).

    Stanikunaite, R., Radwan, MM., Trappe, JM., Fronczek, F., and Ross, SA.*, Lanostane-Type Triterpenes from the Mushroom Astraeus pteridis with Antituberculosis Activity, J. Nat. Prod., 71(12), 2077-2079 (2008).

    Ahmed, SA., Ross, SA.*, Slade D., Radwan, MM., Khan, IA., ElSohly, MA., Absolute configuration of cannabichromanone derivatives from high potency Cannabis sativa , Tetrahedron Letters, 49, pp.6050-6053, (2008).

    Radwan, M.M., ElSohly, M.A., Slade, D., Ahmed,SA., Wilson, L., El-Alfy, AT., Khan, I.A., and  Ross,  S.A.*, Non-Cannabinoid constituents from a high potency Cannabis sativa variety,  Phytochemistry, 69, 2627-2633, (2008).

    Ross, SA.*, Krishnaven, K., Radwan, MM., Takamatsu, S., Burandt, CL., Constituents of Zanthoxylum flavum and their Antioxidant and Antimalarial Activities., Natural Products Communications, 3 (5), 791-794 (2008). 

    Ahmed, SA.,  Ross, SA. *, Slade, D., Radwan, MM., Zulfiqar, F., ElSohly, M., Cannabinoid Ester Constituents from High PotencyCannabis Sativa L., J. Nat. prod., 71(40),536-542 (2008).  

    Radwan, MM., Ross, SA.*, Slade, D., Ahmed, SA., Zulfiqar, F.,ElSohly, M., Isolation and Characterization of New Cannabis Constituents  from High Potency Variety, Planta Medica, 74, 267-272 (2008).

    Radwan, MM., Manly, SP., El-Sayed, KA., Wali, VB., Sylvester, PW., Awate, B., and Ross, SA.*  Sinulodurins A and B, Antiproliferative and Anti-invasive Diterpenes from the Soft Coral Sinularia dura, J.  Nat.  prod. , 71 (8), 1468-1471 (2008).

    Samoylenko, V., Dunbar, DC, Gafur, MD, Khan, SI, Ross, SA, Mossa, JS, El-Feraly, FS, Tekwani, BL, Muhammad,I, Antiparasitic, Nematicidal and Antifouling Constituents from Juniperus Berries, Phytother. Res., 22, 1570-1576 (2008).

    Schuhly, W, Ross, SA , Mehmedic, Z, Fischer, N.H., Essential Oil Analysis of the Follicles of Four North American Magnolia Species, Natural products Communications, 3 (7), 1117-1119 (2008).

    Radwan, MM., Manly, SP., and Ross, SA.*, Two New Sulfated Sterols from Marine Sponge  Lendenfeldia dendyi, Natural Product Communications, 2 (9), 901-904 (2007).

    Stanikunaite, R., Trappe, JM., Khan, SI., Ross, SA.*, Evaluation of Therapeutic Activity of   Hypogeous Ascomycetes and Basidiomycetes from North America, International Journal of Medicinal Mushrooms, 9, 7-14 (2007).

    Sultana, GN, Ross, SA*, Burant,CL, two New Alkaloids from Zanthoxylum syncarpum Tul, Journal of Medicinal and Aromatic Plants Sciences, 28, (2007).

    Ross SA *, Krishnaveni KS, Burandt CL. Two new Benzofuran Derivatives from the Roots of Zanthoxylum flavum, Journal of Chemical Research, June,  406-407 (2006).

    ElSohly MA, Ross SA, Galal AM.  Dihydroartemisinin dihydroartemisitene dimmers as anti-cancer and  anti-infective agents, Unites   States Patent 7,098,242, August 29, 2006.

    Repka MA, ElSohly MA, Munjal M, Ross SA. Temperature Stability and Bioadhesive Properties of D9 -THC Incorporated Hydroxypropylcellulose Polymer Matrix Systems, Drug Development and Industrial Pharmacy,  32, 21-32, (2006).

    Ross SA, ElSohly MA, Sultant GN.  Mehmedic, Z., Hossain, C., and Chandra, S., Flavanoid Glycosides and Cannabinoids from the Pollen of Cannabis sativa L., Phytochemical Analysis, 16, 45-48 (2005).

    Ross SA, Al-Azeib MA, Krishnaveni KS, Fronczek FR, Burant CL.  Alkamides from the leaves of Zanthoxylum syncarpum, J.  Nat.l Prod., 68, 1297-1299 (2005).

    Galal AM, Ross SA, Jackob M, ElSohly MA.  Antifungal Activity of Artemisinin Derivatives, J.  Nat.  Prod., 68, 1274-1276 (2005).

    Ross SA, Sultana GN, Burandt C, ElSohly MA, Marais  JP, Ferreira D.  Syncarpamide, a new Antiplasmodial (+)-Norepinephrine Derivative from Zanthozylum syncarpum, J. Nat. Prod., 67, 88-90 (2004).

    Duncan CJ, Cibula W, Ross SA. A Survey of Southeast North American Wild Growing      Macromycetes Sporophores for Biological Activity, The International Journal of Medicinal Mushrooms, 5, 169-178 (2003).

    Takamatsu S, Galal AM, Ross SA, Ferreira D, ElSohly MA, Ibrahim AS, El-Feraly FS. Antioxidant effect of Flavonoids on DCF-Production in HL-60  Cells, Phytotherapy Research, 17,  963-966 ( 2003).

    Duncan CJ, Cuendet M, Fronczek FR, Pezzuto JM, Mehta RG, Hamann MT, Ross SA. Chemical and Biological Investigation of the Fungus Pulveroboletus ravenelii, J. Nat. Prod., 66, 103-107 (2003).

    Duncan CJ, Pugh N, Pasco DS, Ross SA.  Isolation of a Galactomannan that  Enhances Macrophage Activation from the Edible Fungus, Morchella esculenta, J. Agri. & Food Chemi., 50,  5683-5685 (2002).

    Galal AM, Ross SA, ElSohly MA, ElSohly HN, El-Feraly FS, Ahmed MS, McPhil AT. Deoxy- artemisinin derivatives from Photooxygenation of Anhydrodeoxy dihydroartemisinin and their Cytotoxic Evaluation, J. Nat. Prod.,  65, 184-188, (2002).

    Galal AM, Abourashed EA, Ross SA, ElSohly MA, Al-Said MS, El-Feraly FS.  Daucane Sesquiterpenes from Ferula hermonis; J.  Nat. Prod., 64,  399- 400, (2001).

    ElSohly  MA, Feng S, Murphy  TP, Warrington  AW, Ross SA, Nimrod A, Mehmedic Z. Identification and Quantitation of 11-Nor-9- Tetrahydrocannabivarin-9- Carboxylic Acid, A Major Metabolite of  9-Tetrahydrocannabivarin; J. Analytical Toxicology, 25,   476-480, (2001).

    Pugh N, Ross SA, ElSohly HN, ElSohly MA, Pasco DS.  Isolation of Three High Molecular Weight Polysaccharide Preparations with Potent Immunostimulatory Activity from Spirulina Platensis, Aphanizomenon flos-aquae and Chlorella  pyrenoidosa; Planta  Medica , 67, 737-742, (2001).

    Ahmed MS, Galal AM, Ross SA, Ferriera D, ElSohly MA, Ibrahim AS,Mossa JS, El-Feraly, FS.  A  Weakly   Antimalarial Bioflavanone from Rhus retinorrhoeaPhytochemistry,  58,  599-602, (2001).

    Pugh N, Ross SA, ElSohly MA, Pasco SD.  Characterization of Aloeride, A New  High- Molecular Weight Polysaccharide from Aloe Vera with Potent Immunostimulatory Activity, J. Agri. & Food Chemi., 49,  1030-1034, (2001).

    Salem MY, Ross SA, Murphy MA, ElSohly MA.  GC/MS Determination of Heroin Metabolites in Meconium: Evaluation of Four Solid Phase Extraction Cartridges, J. Anal. Toxic., 25, 93-98, (2001).

    Ross SA, Mehmedic Z, Murphy TP, ElSohly MA. GC/MS Analysis of the Total 9-THC Content of Both Drug and Fiber Type Cannabis Seeds, Journal of Analytical Toxicology,  24,  715-717 (2000).

    Ross SA, Ziska DS, Zhao Ke, ElSohly M.  A.; Variance of Common Flavonoids by Brand of Grapefruit Juice, Fitoterapia, 71 (2), 154-161 (2000).

    Ross SA, Weete JD, Schinazi RF, Wirtz SS, Tharnish P, Scheuer PJ, Hamann MT. Mololipids, A New series of Anti-HIV Bromotyramine-Derived Lipids from a Sponge of the Order Verongida; J. Nat. Prod., 63, 501-503, (2000).

    El-Sayed K, Al-Said MS, El-Feraly FS, Ross SA.  New Quinoline Alkaloids from Ruta chalepensis,      J. Nat. Prod., 63, 995-997, (2000).

    Macias FA, Varela RM, Simonei AM, Cutler HG, Cutler SJ, Ross SA, Dunbar DC, Hill RA. (+)-Brevione A. The First Member of a Novel Family of Bioactive Spiroditerpenoids Isolated from Penicillium brevicompactum Dierckx, Tetrahedron Letters,  41,  2683-2686, (2000).

    ElSohly MA, Feng S, Murphy TP, Ross SA, Nimrod A, Mehmedic Z, Fortner N.  Delta-9-tetrahydrocannabinol (D9-THCV) as a marker for the ingestion of  Cannabis versus Marinol; J. Anal. Toxicology, 23,  222-224, (1999).

    Cutler HG, Ross SA, Elmer AG, Hill RA, Dugan FA, Cutler SJ.  The Chlorotic and Phytotoxic Properties of 9-O-Methylfusarubin from Fusarium oxysporum, Plant Growth Regulation Society of America Quarterly,  27, 1-9 (1999).

    ElSholy, H.N., Joshi, A.S., ZcLi, and Ross, S.A., Flavonoids from Maclura tinctoria:Phytochemistry,Vol. 52 141-145, (1999).

    Cutler, H.G., Cutler, S. J., Ross, S.A., ElSayed, K.A., Dugan, F.M., Barlett, M.G., Spires, A.G., Hill, R.A., Parker, S.R., Koninginin G, A new metabolite from Trichoderma aureoviride Rifai, J. Nat. Prod.,Vol 62 137-139 (1999).