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School of Pharmacy Department of Pharmacognosy

Ikhlas A. Khan

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Assistant Director, Director of FDA Program
Research Professor in the National Center for Natural Products Research, and in the Research Institute of Pharmaceutical Sciences
Professor of Pharmacognosy

Dr Khan received his B. S. degree in Chemistry and Biology from the Aligarh Muslim University, Aligarh (India) in 1980. He obtained his M. S. in Organic Chemistry in 1982 at the same university. In 1987, he received his Ph.D in Pharmacy under the direction of Prof. H. Wagner at the Institute of Pharmaceutical Biology, Munich ( FRG ). Dr Khan joined the Research Institute of Pharmaceutical Sciences (RIPS) , University of Mississippi as a Postdoctoral Research Associate in 1988. In 1990 he received a postdoctoral position with the Department of Pharmacy at the Swiss Federal Institute of Technology, Zurich (Switzerland). In 1992, he was appointed as a Research Scientist in RIPS, University of Mississippi. He was appointed as Research Assistant Professor in RIPS and received a joint appointment in the Department of Pharmacognosy in 1995. In 2001, he was promoted to Associate Professor of Pharmacognosy and Research Associate Professor in the National Center for Natural Products. In 2002, he was appointed as a Assistant Director of the National center for Natural products Research. In 2005, he was promoted to Professor of Pharmacognosy and Research Professor in the Research Institute of Pharmceutical Sciences. In addition, he also serves in the following capacities:

2008-current                      Director, Sino-US TCM Research Center, University of Mississippi
2008-current                      Coordinator, National Products Research Center for Water and Wetlands Research, University of Mississippi
2007-current                      Director, Center for Research of Indian Systems of Medicine (CRISM), University of Mississippi
2005-current                      Research Professor, National Center for Natural Products Research, RIPS, University of Mississippi
2005-current                      Research Professor, Department of Pharmacognosy, School of Pharmacy, University of Mississippi
2002-current                      Assistant Director, National Center for Natural Products Research, University of Mississippi
2001-current                      Director, FDA Program, University of Mississippi

  • Visiting Professor, King Saud University, Saudia Arabia, 2010
  • Visiting Professor, Soochow University, 2010
  • Adjunct Professor, The Chinese University of Hong Kong 2010
  • Promotion Reviewer, King Saud University, Saudia Arabia, 2010
  • Unani Council, India, Advisor, 2010
  • Visiting Professor, Heilongjiang University of Chinese Medicine,  The People’s Republic of China, 2010

 


email: ikhan@olemiss.edu

Click here to see Research in Progress and Publications

  • Research in Progress

  • Dr. Khan's research interests include the applications of analytical tools in the evaluation of quality and safety of dietary supplements, microbial transformation, fingerprinting and standardization of marker compounds in medicinal plant products, Optimization of large scale extraction and isolation of natural products of commercial value. This includes the search of active components from plants used in folk medicine to understand validity of centuries old use of Herbal Medicine which possess antimicrobial, antitumor, anti-inflammatory or immune modulators properties. The development of analytical methods for the quantitation of marker/standard compounds in dietary supplements by HPLC, GC, and LC/MS, and NMR. These methods will help in determining the validity of claims on dietary supplements. Dr. Khan's group is also actively collaborating with other researchers in areas like genetic fingerprinting, cultivation, environmental contamination of plants used as dietary supplements as well as microbial transformation.

  • Representative Publications

  • “Efficient mycobacterial DNA extraction from clinical samples for early diagnosis of tuberculosis”; Kumar, M; Sharma, S; Ram, A.B.; Khan, I.A.; The International Journal of Tuberculosis and lung disease, 2010, 14(7), 847-851.

    “Interaction between topically and systemically coadministered P-glycoprotein substrates/inhibitors:  effect on vitreal kinetics”; Hippalganokar, Ketan; Srirangam, Ramesh; Avula, Bharthi; Khan, Ikhlas A; Majumdar, Soumyajit; Drug Metabolism and Disposition, 2010, 38(10), 1790-1797.

    “Acetabular component deformation under rim loading using digital image correlation and finite element methods”; Everitt, H.; Evans, S.L.; Holt, C.A.; Bigsby, R.; Khan, I.; Applied Mechanics and Materials, 2010, 24-25

    “Neuroprotective Xanthone Glycosides from Swertia punicea”; Xin-Gang Du, Wei Wang, Shi-Ping Zhang, Xiao-Ping Pu, Qing-Ying Zhang, Min Ye, Yu-Ying Zhao, Bao-Rong Wang, Ikhlas A. Khan, And De-ann Guo; J. Nat. Prod., 2010, 73, 1422-1426.

    “Optimized construction of microsatellite-enriched libraries”; Natascha Techen, rene’ E.S. Arias, Neil C. Glynn, Zhiqiang Pan, Ikhlas A. Khan, and Brian E. Scheffler; Molecular Ecology Resources, 2010, 10, 508-515.

    “Antidepressant-like effect of Delta-9-Tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.”; Abir T. El-alfy, Kelly Ivey, Keisha Robinson, Safwat Ahmed, Mohamed Radwan, Desmond Slade, Ikhlas Khan, Mahmoud ElSohly, Samir Ross; Pharmacology, Biochemistry and Behavior, 2010, 95, 434-442.

    “A New Triterpene Glycoside from Centella erecta”; Chidananda S. Rumalla, Zulfiqar Ali, Aruna D. Weerasooriya, Troy J. Smillie, Ikhlas A. Khan; Fitoterapia, 2010, 81, 751-754.

    “Microbial metabolism of cannflavin A and B isolated from Cannabis sativa”; Amany K. Ibrahim, Mohamed M. Radwan, Safwat A. Ahmed, Desmond Slade, Samir A. Ross, Mahmoud A. ElSohly, Ikhlas A. Khan; Phytochemistry, 2010, 71, 1014-1019.  

    “Microbial Metabolism. Part 11.1, Metabolites of Flutamide”; Wimal Herath and Ikhlas Ahmad Khan; Chem. Pharm. Bull., 2010, 58(4), 561-564.  

    “Potency Trends of D9-THC and Other Cannabinoids in Confiscated Cannabis Preparations from 1993-2008”; Zlatko Mehmedic, Suman Chandra, Desmond Slade, Heather Denham, Susan Foster, Amit S. Patel, Samir A. Ross, Ikhlas A. Khan, and Mahmoud ElSohly; J Forensic Sci, 2010, 55(5).

    “Quantitative Determination of Multiple Elements in Botanicals and Dietary Supplements Using ICP-MS”; Bharathi Avula, Yan-Hong Wang, Troy J. Smillie, Nurdan S. Duzgoren-Aydin, and Ikhlas A. Khan; J Agric. Food Chem., 2010, 58, 8887-8894.

    “Ursane triterpenoids from the bark of Terminalia arjuna”; Wei Wang, Zulfiqar Ali, Yunheng Shen, Xing-Cong Li, Ikhlas A. Khan; Fitoterapia, 2010, 81, 480-484.

    “Intestinal and blood-brain barrier permeability of ginkgolides and bilobalide:  in vitro and in vivo approaches”; Madgula, Vamsi L.M.; Avula, Bharathi; Yu, Young-Beob; Wang, Yan-Hong; Tchantchou, Flaubert; Fisher, Scott; Lou, Yuan; Khan, Ikhlas A.; Khan, Shabana I.; Planta Medica, 2010, 76(6), 599-606.

    “18,19-secooleanane type triterpene glycosyl esters from the bark of Terminalia arjuna”; Wang, Wei; Ali, Zulfiqar; Li, Xing-cong; Shen, Yunheng; Khan, Ikhlas A; Planta Medica, 2010, 76(9), 903-908. 

    “Selective inhibition of human leukemia cell growth and induction of cell cycle arrest and apoptosis by pseudolaric acid B”; Ma, Guoyi; Chong, Li; Li, Xing-Cong; Khan, Ikhlas A.; Walker, Larry A.; Khan, Shabana I.; Journal of Cancer Research and Clinical Oncology, 2010, 136(9), 1333-1340.

    “Effects of synephrine and β-phenethylamine on human α-adrenoceptor subtypes”; Ma, Guoyi; Bavadekar, Supriya A.; Schaneberg, Brian T.; Khan, Ikhlas A.; Feller, Dennis R.; Planta Medica, 2010, 76(10), 981-986

    “Medaka (Oryzias Latipes) As A Model to Study Fetal Alcohol Spectrum Disorder,” Yuhui Hu, Minghui Wu, Ikhlas A. Khan, And Asok K. Dasmahapatra, Pregnancy & Alcholol Consumption, Chapter 4(pg 1-24), 2010.

    “Teratogenic Effects of Blue Cohosh (Caulophyllum thalictroides) in Japanese Medaka (Oryzias latipes) Are Probably Mediated through GATA2/EDN1 Signaling Pathway,” Minghui Wu, Yhui Hu, Zulfiqar Ali, Ikhlas A. Khan, A.J Verlangeiri, and Asok K. Dasmahapatra, Chem. Res. Toxicol., online:10.1021/tx100205a.

    “Two New Triterpene Glycosides from Centella asiatica.” Chidananda Swamy Rumalla, Zulfiqar Ali, Aruna D. Weerasooriya, Troy J. Smillie, Ikhlas A. Khan; Planta Med; (2010), 76, 1018-1021

    “Assessment of Cannabinoids Content in Micropropagated Plants of Cannabis sativa and Their Comparison with Conventionally Propagated Plants and Moth Plant during Developmental Stages of Growth,” Chandra, Suman; Lata, Hemant; Medmedic, Zlatko; Khan, Ikhlas A; ElSohly, Mahmoud A, Planta Medica, 2010, 76, 743-750

    “Bioavailability, Pharmacokinetics, and Tissue Distribution of the Oxpregnane Steroidal Gycoside P57AS3(P57) from Hoodia gordonii in Mouse Model,” Madgula, Vamsi; Ashfaq, Mohammad K; Wang,Yan-Hong; Khan, Ikhlas A; Walker, Larry A; Khan, Shabana I, Planta Medica, 2010, 76, 1-5

    “Automated High-Throughput System to Fractionate Plant Natural Products for Drug Discovery,” Tu, Ying; Jeffries, Cynthia; Ruan, Hong; Nelson, Cynthia; Smithson, David; Shelat, Anang A.; Brown, Kristin M.; Li, Xing-Cong; Hester, John P.; Smillie, Troy; Khan, Ikhlas A.; Walker, Larry; Guy, Kip; Yan, Bing, Journal of Natural Products, (2010), 73(4), 751-754.

    “Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice.”  Hou, Yan; Aboukhatwa, Marwa A.; Lei, De-Liang; Manaye, Kebreten; Khan, Ikhlas; Luo, Yuan; Neuropharmacology;  (2010),  58(6),  911-920.

     “Unique discovery aspects of utilizing botanical sources”; Manly, Susan P.; Smillie, Troy; Hester, John P.; Khan, Ikhlas; Coudurier, Louis. Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery; (2010), 213-232. 

    “Composition, standardization and chemical profiling of Banisteriopsis caapi, a plant for the treatment of neurodegenerative disorders relevant to Parkinson's disease”; Wang, Yan-Hong; Samoylenko, Volodymyr; Tekwani, Babu L.; Khan, Ikhlas A.; Miller, Loren S.; Chaurasiya, Narayan D.; Rahman, Md. Mostafizur; Tripathi, Lalit M.; Khan, Shabana I.; Joshi, Vaishali C.; Wigger, Frank T.; Muhammad, Ilias;  Journal of Ethnopharmacology;  (2010),  128(3),  662-671.

    “A Comprehensive Approach to Identifying and Authenticating Botanical Products”; Smillie, TJ, Khan, IA; “Clinical Pharmacology and Therapeutics”; VOLUME 87 NUMBER 2, | February, 2010.

    “Assessment of the genetic stability of micropropagated plants of Cannabis sativa by ISSR markers”; Lata, Hemant; Chandra, Suman; Techen, Natascha; Khan, Ikhlas A.; ElSohly, Mahmoud A.: Planta Medica;  (2010),  76(1),  97-100

    “Quantitative determination of flavonoids and cycloartanol glycosides from aerial parts of Sutherlandia frutescens (L.) R. BR. by using LC-UV/ELSD methods and confirmation by using LC-MS method”; Avula, Bharathi; Wang, Yan-Hong; Smillie, Troy J.; Fu, Xiang; Li, Xing Cong; Mabusela, Wilfred; Syce, James; Johnson, Quinton; Folk, William; Khan, Ikhlas A;  Journal of Pharmaceutical and Biomedical Analysis; (2010),  52(2),  173-180.

    “Banisteriopsis caapi, a unique combination of MAO inhibitory and antioxidative constituents for the activities relevant to neurodegenerative disorders and Parkinson's disease”;  Samoylenko, Volodymyr; Rahman, Md. Mostafizur; Tekwani, Babu L.; Tripathi, Lalit M.; Wang, Yan-Hong; Khan, Shabana I.; Khan, Ikhlas A.; Miller, Loren S.; Joshi, Vaishali C.; Muhammad, Ilias; Journal of Ethnopharmacology;  (2010),  127(2),  357-367.

    “Neolignans from the Leaves of Casearia sylvestris:’ Swartz.Wang, Wei; Ali, Zulfiqar; Li, Xing-Cong; Khan, Ikhlas A.;Helvetica Chimica Acta;  (2010),  93(1),  139-146.

    “Characterization of in vitro pharmacokinetic properties of hoodigogenin A from Hoodia gordonii”; Madgula, Vamsi Lakshmi Mohan; Avula, Bharathi; Pawar, Rahul S.; Shukla, Yatin J.; Khan, Ikhlas A.; Walker, Larry A.; Khan, Shabana I.; Planta Medica; (2010),  76(1),  62-69.

    “Design, synthesis, and biological evaluation of 3,4,5-trimethoxyphenylacrylamides as antinarcotic agents”; Jung, Jae-Chul; Min, Dongguk; Kim, Heejeong; Jang, Soyong; Lee, Yongnam; Park, Woo-Kyu; Khan, Ikhlas A.; Moon, Hyung-In; Jung, Mankil; Oh, Seikwan: Journal of Enzyme Inhibition and Medicinal Chemistry; (2010),  25(1),  38-43.

    “Flavonol glycosides from the south african medicinal plant Sutherlandia frutescens”; Fu, Xiang; Li, Xing-Cong; Wang, Yan-Hong; Avula, Bharathi; Smillie, Troy J.; Mabusela, Wilfred; Syce, James; Johnson, Quinton; Folk, William; Khan, Ikhlas A.;  Planta Medic;  (2010),  76(2),  178-181.

    The Role of Chemical Fingerprinting: Application to Ephedra, B.T. Schaneberg, S. Crockett, E. Bedir and I. A. Khan, Phytochemistry, accepted.

    An improved HPLC Method for Quantitative Determination of Six Triterpenes in Centella asiatica Extracts and Commercial Products, B.T. Schaneberg, J.R. Mikell, E. Bedir, and I.A. Khan, Die Pharmazie, accepted.

    Microbial transformation of phthalideisoquinoline alkaloid,(-)-B-hydrastine Herath, W.H.M.W., Ferreira, D., Khan, I.A., Natural Product Letters, accepted.

    Microbial metabolites of Harman alkaloids. Herath, W.H.M.W., Mikell, J.R., Ferreir, D., Khan, I.A., Phytochemistry, accepted.

    Microbial transformation of xanthohumol. Herath, W.H.M.W., Ferreier, D., Khan, I.A., Phytochemistry, accepted.

    Evaporative Light Scattering Detection of Pyrrolizidine Alkaloids B.T. Schaneberg, R.J. Molyneux and I.A. Khan, Phytochemical Analysis, accepted.

    Quantitative Analysis of Forskolin in Coleus forskohlii (Lamiaceae) by Reverse Phase High Performance Liquid Chromatography, B.T. Schaneberg and I.A. Khan, Journal of AOAC International, accepted.

    Quantitative Analysis of Withanolides in Withania somnifera (Ashwagandha) by High Performance Liquid Chromatography, M. Ganzera, M.I. Choudhary, I.A. Khan, Fitoterapia, accepted.

    Anxiolytic Properties of Piper methysticum extract samples and fractions in the Chick Social-Separation Stress Procedure, M. Feltenstein, L.C. Lambdin, M. Ganzera, R. Dharmaratne, D. Nanayakkara, I.A. Khan, K.J. Sufka, Phytotherapy Research, accepted.

    HPLC Fingerprinting and Estimation of Bioactive Components of Clutia richardiana L. as a Potential Hypoglycemic Herbal Tea, E.A. Abourashed, M. Ganzera, I.A. Khan, S. Khan, J.S. Mossa, F.S. El-Feraly, Phytotherapy Research, November (2001), accepted.

    High-Speed Extraction and HPLC Fingerprinting of Medicinal Plants- II. Application to Harman Alkaloids of Genus Passiflora, Ehab. A. Abourashed, John Vanderplank, and I.A. Khan, Pharmaceutical Biology, accepted.

    Determination of Saponins and Alkaloids in Caulophyllum thalictroides (Blue Cohosh) by High Performance Liquid Chromatography and Evaporative Light Scattering Detection, M. Ganzera, H.R.W. Dharmaratne, N.P.D. Nanayakkara, I.A. Khan, Phytochemical Analysis, accepted.

    Two new prosapogenins from Albizia adianthifolia, Haddad, M., Khan, I., and Lacaille-Dubois , M.A., Die Pharmazie, 57 (10), 705-708, (2002), Jan 2002.

    In vitro Plant Regeneration from Leaf-derived Callus of Cimicifuga racemosa, H.Lata, E. Bedir, A. Honsik, M. Ganzera, I.A. Khan, R.M. Moraes, Planta Medica, 68(10), 912-915, (2002).

    Determination of Aristolochic acid I and II in North American Species of Asarum and Aristolochia, B. T. Schaneberg, W. L. Applequist and I.A. Khan, Die Pharmazie, 57 (10), 686-689, (2002).

    Anti-apoptotic Properties of Ginkgo biloba Extract EGb761 in Differentiated PC12 Cells Smith, J., Burdick, A., Golik, P., Khan, I., Wallace, D., Luo, Y.. Cellular & Mol. Biology, 48(6), 699-707, (2002).

    Ginkgo biloba Extract EGb761 Increases Stress Resistance and Extends Life Span of Caenorhabditis elegans Wu, Z., Smith, J., Paramasivam, V., Butko, P., Khan, I., Cypser, J. R., Luo, Y. Cellular & Mol. Biology, 48(6), 725-731, (2002)

    Inhibition of Amyloid-? Aggregation and Caspase-3 Activation by the Ginkgo biloba Extract EGb761 Luo, Y., Smith, J., Paramasivam, V., Burdick, A., Curry, K. J., Buford, J. P., Khan, I., Netzer, W. J., Xu, H., Butko, P.. Proc. Natl. Acad. Sci. 99(19), 12197-12202, (2002).

    Determination of beta Adrenergic Receptor Blocking Pharmaceuticals in United States Water Effluent,; D. B. Hugget, I. A. Khan, J. C. Allgood, C. M. Foran, D. Schlenk, Water Research, 121(2) 199-205, 2003.

    Fatty Acid Synthase inhibitors from Plants: Isolation, Structure Elucidation and SAR Studies. Li, Xing-Cong; Joshi, Alpana S; El Sohly, Hala N.; Khan, Shabana I.; Jacob, Melissa R.; Zhang Zhizheng; Khan, Ikhlas A.;Ferreira, Daneel; Walker, Larry A., Broedel, Sheldon E, J.; Raulli, Robert E.; Cihlar, Ronald L. J. Nat. Prod., AN 2002:851257, CA.

    3?,4?-epoxyvalerenic acid from Valeriana officinalis, H. Ranjith W. Dharmaratne, N. P. Dhammika Nanayakkara and Ikhlas A. Khan, Planta Medica, 68(7), p.661-662, (2002).

    Characterization of the Estrogenic Response to Genistein in Japanese medaka (Oryzias latipes), L. Zhang, I. A. Khan and C. M. Foran , Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 132C(2), p. 203-211, (2002).

    Composition of the Essential Oil of Lepidium Maynii; Tellez, Mario R., Khan Ikhlas A., Kobaisy, Mozaina, Ashrader, Kevin K., Dayan, Frank E. and Weste, Osbrink, Phytochemistry 61(2), p.149-155, (2002).

    The Inhibitory Activity of Natural Products on Plant p-Hydroxyphenylpyruvate Dioxygenase, G. Meazza, B.E. Scheffler, M.R. Tellez, A.G. Rimando, J.G. Romagni, S.O. Duke, D. Nanayakkara, I.A. Khan, E.A. Abourashed, and Dayan, Phytochemistry, 60(3), p.281-288, (2002).

    Three new triterpene saponins from two species of Carpolobia, Mitaine-Offer, A.C. Miyamoto, T., Khan, I., Delaude, C., and Lacaille-Dubois, M.A., J. Nat. Prod., 65(4), p.553-557, (2002).

    Biologically Active Steroidal Glycosides from Tribulus terresteris, Erdal Bedir, Ikhlas A. Khan and Larry A. Walker, Biol. Pharm. Bull, 57 (7) p. 491-494, (2002).

    Chemical Profiling and Standardization of Lepidium meyenii (Maca) by Reversed Phase High Performance Liquid Chromatography, M. Ganzera, J. Zhao, I. Muhammad, I.A. Khan, Chem Pharm Bull, 50(7) p.988-991 (2002)

    Biologically Active Secondary Metabolites from Ginkgo biloba, Erdal Bedir, Irem I. Tatli, Riaz A. Khan, Jianping Zhao, Satashi Takamatsu, Larry A. Walker, Peter Goldman and Ikhlas A. Khan, J. Agri. Food Chem. 50 (11), pp.3150-3155, (2002).

    Evaluation of Podophyllum peltatum accessions for podophyllotoxin production, Rita Moraes, Ebru Bedir, Holly Barret, Charls Burandt Jr., Camilo Canel and Ikhlas Khan, Planta medica, 68, 341-344, (2002)

    Constituents of Lepidium meyenii (Maca), Ilias Muhammed, Jianping Zhao, D. Chuck Dunbar, Ikhlas A. Khan, Phytochemistry, 59(1), 105-110, (2002).

    Kavalactones from Piper methysticum and 13C-NMR Spectroscopic analyses, H. Ranjith W. Dharmaratne, N. P. Dhammika Nanayakkara and Ikhlas A. Khan, Phytochemmistry, 59 (4), 429-433, (2002).

    The Ginkgolide Hydrates: Ginkgolide A, Ginkgolide C and Ginkgolide J,; Zhao Jianping, Ilias Muhammad, D. Chuck Dunbar, Ikhlas A. Khan, Nikolaus H. Fischer and Frank R. Fronczek, Acta Crystallographia, 58(3), 195-198,(2002).

    Comparison of Extraction Methods for Marker Compounds in the Essential oil of Lemon Grass by GC, Schaneberg, Brian T., Khan, Ikhlas Khan A. J. Agri. and Food Chemistry, 50 (6), 1345-1349, (2002).

    Hypericum perforatum- Chemical Profiling and Quantitative Results of St. John's Wort Products by an improved High Performance Liquid Chromatography Method,; M. Ganzera, J. Zhao and I. A. Khan. J. Pharm. Sci, 91 (3), 6223-630, (2002).

    High-Speed Extraction and HPLC Fingerprinting of Medicinal Plants- I. Application to Passiflora Flavonoids, Ehab. A. Abourashed, John Vanderplank, and I.A. Khan, Pharmaceutical Biology, 40(02), pp. 81-91, (2002).

    The Ethnomedicinal Use of Magnoliaceae from the Southeastern United States as Leads in Drug Discovery, Wolfgang Schuhly, Ikhlas Khan and Nikolaus H. Fischer, Pharmaceutical Biology, 39, 63-69, (2001).

    GC Determination of Parthenolide in Feverfew Products,; E. A. Abourashed and I. A. Khan, Die Pharmazie, 56(12), 971-972, (2001).

    Analysis of Sesquiterpenes in Valeriana officinalis by Capillary Electrophoresis, J.R. Mikell, M. Ganzera, I. A. Khan, Die Pharmazie, 56(12), 946-948, (2001).

    Determination of Steroidal Saponins in Tribulus terrestris by Reversed-Phase High Performance Liquid Chromatography and Evaporative Light Scattering Detection, M. Ganzera, E. Bedir, I. A. Khan, J. Pharm. Sci., 90, 1752-1758, (2001).

    A new lignan Glycoside from Eleutherococcus senticosus,; Xing-Cong Li, Dayna L. Barnes and Ikhlas A Khan, Planta medica, 67, 776-778, (2001).

    A Reversed Phase High Performance Liquid Chromatography method for the Analysis of Boswellic Acids in Boswellia serrata,; Markus Ganzera and Ikhlas A. Khan, Planta medica, 67, 778-780, (2001).

    Analysis of Sesquiterpene Lactones in Magnolia grandiflora L. by Micellar Electrokinetic Capillary Chromatography, M. Ganzera, M. Mair, H. Stuppner, N. Fischer, I.A. Khan, Chromatographia, 54, 665-668, (2001).

    Determination of Nepetalactone in Nepeta cataria by Reversed Phase High Performance Liquid Chromatography, M. Ganzera, S. Crockett, M. Tellez, I.A. Khan, Die Pharmazie, 56, 896-897, (2001).

    Drug Absorption In Vitro Model: Filter-Immobilized Artificial Membranes. 2a Studies of the permeability Properties of Lactones in Piper methysticum Forst,; Alex Avdeef, Melissa Strafford, Eric Block, Michael P. Balogh, Walter Chambliss and Ikhlas Khan, Eur. J. Pharm. Sci, 14(2), 271-280, (2001).

    Analysis of Terpenelactones in Ginkgo biloba by High Performance Liquid Chromatography and Evaporative Light Scattering Detection, M. Ganzera, J. Zhao, I.A. Khan, Chem. Pharm. Bull, 49(9), 1170-1173, (2001).

    Separation and Quantification of the Major Daucane Esters of Ferula hermonis by HPLC,; Ehab Abourashed, Ahmad Galal, and Ikhlas Khan, Planta Medica, 67, 681-682, (2001).

    Trojanosides I-K: New cycloartane-type glycosides from the aerial part of Astragalus trojanus,; Erdal Bedir, Irem I. Tatli, Ihsan Calis and Ikhlas A. Khan, Chem. Pharm Bull, 49 (11) 1482-1486, (2001).

    Antimalarial(+)-trans-Hexahydrodibenzopyran Derivative from Machaerium multiflorum,; Ilias Muhammed, Xing-Cong Li, Chuck Bunbar, Mamoud A. Elsohly and Ikhlas A. Khan. J. Nat. Prod, 64(10),1322-1325, (2001).

    Improved HPLC Method for Determination of Betaine in Biological samples,; Markus Ganzera, Pedro Pujol, Larry A. Walker, I. A. Khan. Die Pharmazie, 56(7), 552-553, (2001).

    HPLC Determination of Hydrastine and Berberine in Selected Goldenseal Products,; E. A. Abourashed and I. A. Khan. J. Pharm. Sci., 90(7), 817-822, (2001).

    Improved Method for the Determination of Oxindole Alkaloids in Uncaria tomentosa by High Performance Liquid Chromatography, M. Ganzera, I. Muhammad, R. A. Khan, I. A. Khan, Planta Medica, 67, 447-450, (2001).

    Separation of Astragalus Saponins by Reversed-Phase High Performance Liquid Chromatography and Evaporative Light Scattering Detection,; M. Ganzera, E. Bedir, I. Calis, I. A. Khan, Chromatographia , 53 (3/4), 131-134, (2001).

    Anxiolytic effects of kava extract and kavalactones in the Chick Social Separation-Stress Paradigm,; Kenyatta K. Smith, Ranjith Dharmaratne, Matt W. Feltenstein, Susan L. Broom, J. Todd Roach, Dhammika Nanayakkara, Ikhlas A. Khan and Kenneth J. Sufka. Psychopharmacology, 155(1), 86-90, (2001).

    The Stereoisomeric Pentacyclic Oxindole Alkaloids: Uncarine C and Uncarine E,; Ilias Muhammad, Ikhlas A. Khan, Nikolaus H. Fischer, Frank R. Fronczek, Acta Crystallograhia, C57(4), 480-482, (2001).

    Investigation of Una De Dato.II. Anew Uncaria constituent and 15N NMR spectroscopic studies on Pentacyclic Oxindole Alkaloids,; Illias Muhammad, D. Chuck Dunbar, Riaz A. Khan, Markus Ganzera and Ikhlas A. Khan, Phytochemistry, 57(5), 781-785, (2001).

    Analysis of Marker Compounds of Rhodiola rosea (Golden Root) by Rp-HPLC, Markus Ganzera, Yurdanur Yayla and Ikhlas A. Khan, Chem Pharm. Bull., 49(4), 465-467, (2001).

    Two Novel Cycloartane-Type Triterpene Glycosides from the Roots of Astragalus prusianus,; Erdal Bedir, Ihsan Calis, Chuck Dunbar, Rudraksh Sharan, John K. Buolamwini, Ikhlas A. Khan,Tetrahedron, 57, 5961-5966, (2001).

    A New Cyclolanostanol Arabinoside from the Rhizome of Cimicifuga racemosa,; Erdal Bedir, and Ikhlas A. Khan, Die Pharmazie, 56, 268-269, (2001).

    Determination of Heavy Metals and Pesticides in Ginseng Products,; Ikhlas A. Khan, James Allgood, Ehab A. Aborurashed, D. Schlenk, Larry A. Walker, and William H. Benson, J. Assoc. Off. Anal. Chem, 84(3), 936-939, (2001).

    High Yield of Podophyllotoxin from Leaves of Podophyllum peltatum by in-situ Conversion of Podophyllotoxin 4-O-beta-D-glucopyranoside, C. Canel, F. Dayan, M. Ganzera, I. A. Khan, A. Rimando, C.L. Burandt, and R.M. Moraes, Planta Medica, 67, 1-3, (2001).

    Podophyllotoxin Lignans Enhance IL-1b but Suppress TNF-? mRNA Expression in LPS-Treated Monocytes,; Nirmal Pugh, Ikhlas A. Khan, Rita M. Moraes and David S. Pasco, J. of Immunopharmacology and Immunotoxicology, 23 (1), 83-95, (2001).

    Organochlorine Pesticides and Metals in Select Botanical Dietary Supplements;. D.B. Huggett, I. A. Khan, J. C. Allgood, D. S. Block, D. Schlenk. Bulletin of Environmental Contamination and Toxicology, 66, 150-155, (2001).

    A New Dammarane-Type Triterpene Glycoside From Polyscias fulva (Hiern) Harms,; Erdal Bedir, Ngeh J. Toyang, Ikhlas A. Khan, Larry A. Walker, Alice M. Clark, J. Nat. Prod., NP0003589, (2001).