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School of Pharmacy Department of Pharmacognosy

Mark T. Hamann

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Professor of Pharmacognosy, Pharmacology, Chemistry & Biochemistry

Adjunct Professor Institute of Marine and Environmental Technology University of Maryland Center for Environmental Science


B.S. degree in Chemistry and Biology from Bemidji State University in Bemidji, Minnesota in 1985.
Chemist for Reid-Rowell labs (Solvay Pharmaceuticals) in Baudette Minnesota from 1985-1988.
Ph. D. in Marine Natural Products Chemistry under the direction of the Late Professor Emeritus Paul J. Scheuer at the Department of Chemistry of the University of Hawaii, Manoa in 1992.

Honors and Awards

Section Editor of Biochimica and Biophysica et Acta 2006-
Guest Editor of Molecules Special Issue “Antiinfective Agents” 2009-2010
Member of The Journal of Natural Products Editorial Board
Member of Editorial Board for Botanics: Targets and Therapy.
Author of a new and controversial finding selected by the Faculty of 1000 Biology Reports 2010
Author of the top download paper of the year 2005 (awarded in 2006) in Comparative Biochemistry and Physiology
Member of the NIH Synthetic and Biological Chemistry Study Section 2010-
Ad Hoc Member of the NIH AIDS Special Emphasis Panel (ZRG1 AARR-E) 2007-2009
Ad Hoc Member of the Florida Sea Grant Marine Biotechnology and Sustainable Production Panel 2007
Chair of an NIH Ad Hoc and Experimental Electronic Review Section for NIH F32 Fellowships Applications (ZRG1 AARR-D22L) AIDS Fellowships 2006
Member of the NIH AIDS Discovery and Development of Therapeutics (ADDT) Study Section 2003-2006
Scientific Program Committee for the International Meeting on Marine Biotechnology 2004

Biography

Dr. Hamann is a Professor of Pharmacognosy, Pharmacology, Chemistry & Biochemistry as well as a Research Professor with the National Center for Natural Products Research at the University of Mississippi and an Adjunct Professor with the Center of Marine Biotechnology (COMB), University of Maryland Biotechnology Institute (UMBI). Dr. Hamann received his B.Sc. in Chemistry & Biology from Bemidji State University in Minnesota. He has several years experience in GMP pharmaceutical manufacturing and then completed a Ph.D. degree in Marine Natural Products Chemistry in 1992 at the University of Hawaii, Chemistry Department under the guidance of the late Professor Paul Scheuer -a pioneer in the discovery and chemical ecology of marine natural products. During his 20-year research career, Dr. Hamann has published over 100 scientific papers, reviews and book chapters. He has received numerous awards and honors, organized numerous scientific symposia and meetings and frequently delivers keynote or plenary presentations at international conferences. Dr. Hamann's research program includes an extensive array of collaborations with the Pharmaceutical and Biotechnology industry as well as Federal research programs focused on the development of treatments for infectious, neurological diseases and cancer from marine derived secondary metabolites. Dr. Hamann's group has a small pipeline of marine natural product drug leads. The most advanced product currently investigated by his research group are the kahalalides. The lead compound, Kahalalide F is covered by U.S. patent number 6,274,551 which is assigned to PharmaMar S.A., a pharmaceutical company in Madrid. PharmaMar is developing this novel class of anticancer agents, and Kahalalide F is currently in phase II clinical trials.

email:mthamann@olemiss.edu

Click here to see Research in Progress and Publications

    Research in Progress

    Dr. Hamann's research group is actively involved in the isolation, structure assignment using NMR and synthesis of marine natural products with activity against cancer, malaria, tuberculosis and neurological disorders. Metabolites are isolated from a variety of sources including marine invertebrates, algae, bacteria and dinoflagellates. In addition to drug leads Dr. Hamann's group is involved in the characterization of molecules associated with harmful algal blooms and the role of symbiosis on the production of invertebrate secondary metabolites. NMR structure assignments are made utilizing two dimensional methods to assign gross, relative and absolute configuration. Molecular modeling is utilized extensively to assist with and validate NMR assignments and a combination of chemical and spectroscopic methods are utilized to solve relative and absolute configuration. A combination of synthesis and biosynthesis are utilized together to assemble and optimize complex, biologically active marine natural products. Some of the classes of marine natural products characterized can be generated effectively utilizing total synthesis however for many classes a combination of biosynthesis and chemical synthesis are essential to generate a product cost-effectively.

    Click here to see more detailed notes about current research efforts.

    Click here to see research collaborators.

    Click here to see graduate students and visitng scholars

    Representative Publications

    (* denotes corresponding author)

    Submitted Manuscripts

  • Huayue, L., Bowling, J.J., Fronczek, F.R., Hong, J., Murray, T.F., Hamann, M.T., and Jung, J.H. 2011 (submitted). Crystal Structure of a Unique Marine Knottin Peptide from the Sponge Asteropus sp. Journal of the American Chemical Society.
  • Meujo D.A.F., Peng J., Na M., Schinazi R.F. and Hamann M.T. 2010 (Under Review - Journal of Natural Products). Antifungal and Anti-Hepatitis C Virus (HCV) Cyclic Peroxides Isolated from a Jamaican Sponge of the Genus Plakinastrella.
  • Wang, B., Patel, R.Y., Prasanna, S., Doerksen, R.J., and Hamann, M.T.* 2011 (submitted). Kinases of Mycobacterium tuberculosis: classification, structures, and the development of inhibitors. Chemical Reviews.
  • Wahba, A.E. and Hamann.*, M. T. 2011 (submitted). Reductive Alkylation of Nitroarenes: A practical Approach for Mono N-Alkylation of Natural Products. Journal of Organic Chemistry.  
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    Manuscripts Under Revision

  • Sims, J.W., Peraud, O., Kasanah, N., Rao, K.V., Anderson, M.A., Hill, R.T.,* and Hamann, M.T.* 2011 (under revision). Evidence of a complex microbial-sponge symbiotic relationship in the biosynthesis of manzamine alkaloids. PNAS.  
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    In Press Manuscripts

  • Meujo D. A. F. and Hamann M.T., "Science, Policy, and Risk Management: The Case of Seafood Safety" - Environmental Toxicology – Encyclopedia of Sustainability Science and Technology. 2011. (In Press -Elsevier).  
  • Published Papers

    Gao, J. and Hamann, M.T.* 2011. Chemistry and Biology of Kahalalides. Chemical Reviews. 111, 3208-3233.

    Shilabin, A.G. and Hamann, M.T.* 2011. In vitro and in vivo evaluation of select kahalalide F analogs with antitumor and antifungal activities. Bioorganic and Medicinal Chemistry. 19, 6628-6632.

    Xu, T. Q. Feng, M.R. Jacob, B. Avula, M.M. Mask, S.R. Baerson, S.K. Tripathi, R. Mohammed, M.T. Hamann, I.A. Khan, L.A. Walker, A.M. Clark and A.K. Agarwal* 2011. The Marine Sponge-Derived Polyketide Endoperoxide Plakortide F Acid mediates its antifungal activity by interfering with calcium homeostasis. Antimicrobial Agents and Chemotherapy. 55, 1611-1621.

    Rodrigo, G., G.R. Almanza, Y. Cheng, J. Peng, M.T. Hamann, R.D. Duan and B. Akesson. 2010. Antiproliferative effects of curcuphenol, a sequiterpene phenol. Fitoterapia. 81(7), 762-766.

    Bowling, J., Mohammed, R., Diers, J.A. and Hamann, M.T.* 2010. Abundant ketone isolated from oily Plakortis sponge demonstrates antifouling properties. Chemoecology. 20, 207-213.

    He, Y.Q., Z.Y. Ma, Q. Yang, B.Z. Du, Z.X. Jing, B.H. Yao, M.T. Hamann. 2010. Diterpenoid alkaloids and flavonoids from Delphinium albocoeruleum Maxim. Biochemical Systematics and Ecology. 38(4), 2010.

    Kochanowska-Karamyan, A.J. and Hamann, M.T.* 2010. Marine indole alkaloids: potential new drug leads for depression and anxiety. Chemical Reviews. 110, 4489-4497.

    Wahba, A.E. and Hamann, M.T.* 2010. New one-pot methodologies developed for the modification or the synthesis of alkaloids scaffolds, Marine Drugs 8, 2395-2416.

    Waters, A.L., Hill, R.T., Place, A.R. and Hamann, M.T.* 2010. The expanding role of marine microbes in pharmaceutical development.  Current Opinions in Biotechnology, 21(6) 780-786.   

    Meujo, D.A.F, D. Kevin, J. Peng, J.J. Bowling, J. Liu and M.T. Hamann.* 2010. Reduced oyster-associated bacteria levels using supercritical fluid CO2 as an agent of warm pasteurization. Link International Journal of Food Microbiology 138 63-70.

    Na, M., Y. Ding, B. Wang, R.S. Schinazi, M. Kelly, M., R. Stone, X.C. Li, D. Ferreira and M.T. Hamann.* 2010. Anti-infective discorhabdins from a deep-water Alaskan sponge of the genus Latrunculia. Link Journal of Natural Products. 73, 383-387.

    Peng, J., S. Kudrimoti, S. Prasanna, S. Odde, R.J. Doerksen, H.K. Pennaka, Y.M. Choo, K.V. Rao, B.L. Tekwani, V. Madgula, S.I. Khan, B. Wang, A.S.M. Mayer, M.R. Jacob, L.C.Tu, J. Gertsch and M.T. Hamann.* 2010. Structure-Activity Relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections. Link Journal of Medicinal Chemistry 53, 61-76.

    Peng, J., A.R. Place W. Yoshida, C. Anklin and M.T. Hamann.* 2010. Structure and Absolute Configuration of Karlotoxin-2, an Ichthyotoxin from the Marine Dinoflagellate Karlodinium veneficum. Link Journal of American Chemical Society. 132, 3277-3279.

    Gao, J., Caballero-George, C., Wang, B., Rao, K., Shilabin, A.G., M.T. Hamann.* 2009. 5-OHKF and norKA, Depsipeptides from a Hawaiian collection of Bryopsis pennata: Binding properties for norKA to the human neuropeptide Y Y1 receptor. Link Journal of Natural Products. 72(12), 2172-2176.

    Ibrahim, M.A., A.A. Mansoor, A. Gross. M.K. Ashfag, M. Jacob and M.T. Hamann.* 2009. Methicillin-resistant Staphylococcus aureus (MRSA)-active metabolites from Platanus occidentalis (American sycamore), Link Journal of Natural Products 72(12), 2141–2144

    Kudrimoti, S, Ahmed, S. A., Daga, P. R., Wahba, A. E., Khalifa, S. I., Doerksen, R. J., Hamann.*, M. T. 2009. Semi-synthetic Latrunculin B Analogs: studies of actin Docking support a proposed mechanism for latrunculin Bioactivity. Link Bioorganic and Medicinal Chemistry, 17, 7517-7522.

    Wahba, A.E., J. Peng and M.T. Hamann.* 2009. Reductive Amidation of Nitroarenes: A Practical Approach for Amidation of Natural Products. Link Tetrahedron Letters 50, 3901-3904.

    Wahba, A. E., Peng, J., Kudrimoti, S., Tekwani, B. L., M. T. Hamann.* 2009. Structure activity relationship studies on manzamine A: modification of positions 6 & 8 of the ß-carboline moiety. Link Bioorganic and Medicinal Chemistry, 17, 7775-7782.

    Mayer, A.M.S.*, A.D. Rodriguez, R.G.S. Berlink and M.T. Hamann 2009. (in press) Marine pharmacology in 2005-2006: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action. Link Biochimica and Biophysica et Acta 1772.

    Kevin II, D.A., D.A.F. Meujo and M.T. Hamann 2009. Polyether Ionophores: Broad-spectrum and Promising Biologically Active Molecules for the Control of Drug-resistant Bacteria and Parasites. Link Expert Opinion in Drug Discovery 4(2), 109-147.

    El Sayed, K.A., A.A. Khalil, M. Yousaf, G. Labadie, G.M. Kumar, S.G. Franzblau, A.M.S. Mayer, M.A. Avery and M.T. Hamann* 2008. Semisynthetic Studies on the Manzamine Alkaloids. Link Journal of Natural Products 71, 300-308.

    Bowling, J.J., H.K. Pennaka, K. Ivey, S. Wahyuono, M. Kelly, R.F. Schinazi, F.A. Valeriote, D.E. Graves and M.T. Hamann.  2008. Antiviral and anticancer optimization studies of the DNA-binding marine natural product aaptamine. Chemical Biology and Drug Design 71(3), 205-215.

    Shilabin, A.G., N. Kasanah, B.L. Tekwani and M.T. Hamann* 2008.  Kinetic studies and bioactivity of potential manzamine prodrugs. Link Journal of Natural Product. 71(7) 1218-1221.

    Rao, K.V., M.K. Na, J.C. Cook, J. Peng, R. Matsumoto and M.T. Hamann.  2008.  Kahalalides V–Y Isolated from a Hawaiian Collection of the Sacoglossan Mollusk Elysia rufescens. Link Journal of Natural Products, 71; 772-778.

    Na, M., D.A.F. Meujo, D. Kevin, M.T. Hamann,* M. Anderson, R.T. Hill. 2008. A New Antimalarial Polyether from a Marine Streptomyces sp. H668. Link Tetrahedron Letters, 49 (44), 6282-6285.

    Mohamed, N.M., K.V. Rao, M.T. Hamann, M. Kelly and R.T. Hill* 2008. Monitoring bacteria diversity of the marine sponge Ircinia strobilina on transfer to aquaculture.  Link Applied and Environmental Microbiology 74 (13), 4133-4143.

    Donia, M.S., B. Wang, D.C. Dunbar, P.V. Desai, A. Patny, M. Avery and M.T. Hamann*  2008.  Mollamides B and C, cyclic hexapeptides from the Indonesian Tunicate Didemnum molleLink Journal of Natural Products 71 (6), 941-945.

    Tatli, I.I., X. Feng, G. Carter, K.V. Rao and M.T. Hamann* 2008. 7-Methyl-9-oxo-dec-7-eneoic acid from the Red Sea sponge Ircinia sp. Journal of Chemical Research, January, 50-51.

    J.A. Diers, K.D. Ivey, A. El-Alfy, J. Shaikh, J. Wang, A.J Kochanowska, J.F. Stoker, M.T. Hamann and R.R. Matsumoto* 2008.  Identification of antidepressant drug leads through the evaluation of marine natural products with neuropsychiatric pharmacophores. Link Pharmacology Biochemistry and Behavior 89, 46-53.

    Kochanowska, A.J., K.V. Rao, S. Childress, A. El-Alfy, R.R. Matsumoto, M. Kelly, G.S. Stewart, K.J. Sufka and M.T. Hamann* 2008.  Secondary metabolites from three Florida sponges with antidepressant activity.Link Journal of Natural Products 71, 186-189.

    Ahmed, S.A., S.I. Khalifa and M.T. Hamann* 2008.  Antiepileptic ceramides from the Red Sea sponge Negombata corticata. Link Journal of Natural Products 71 (4) 513-515.

    Ibrahim, M.A., A.G. Shilabin, S. Prasanna, M. Jacob, S.I. Khan, R.J. Doerksen and M.T. Hamann* 2008. 2-N-Methyl Modifications and SAR Studies of Manzamine A. Link Bioorganic and Medicinal Chemistry 16, 6702-6706.

    Fan, H., J. Peng, M.T. Hamann and J.F. Hu* 2008.  Lamellarins and related pyrrole-derived alkaloids from marine organisms. Link Chemical Reviews 108, 264-287.

    Bowling, J.J., A.J. Kochanowska, N. Kasanah and M.T. Hamann* 2007.  Nature’s bounty-drug discovery from the sea. Link Expert Opinion in Drug Discovery 2(11), 1505-1522.

    Ahmed, S.A., S. Odde, P.R. Daga, J.J. Bowling, M.K. Mesbah, D.T. Youssef, S.I. Khalifa, R.J. Doerksen and M.T. Hamann* 2007.  Latrunculin with a highly oxidized Thiazolidone ring: structure assignment and actin docking. Link Organic Letters 9(23), 4773-4776.

    Gul, W., N.L. Hammond, M. Yousaf, J. Peng, A. Holley and M.T. Hamann* 2007. Semisynthetic studies of the bioactive marine sesquiterpene (S)-(+)-curcuphenol isolated from a deep reef collection of several Jamaican sponges. Link Biochimica and Biophysica et Acta 1770, 1513-1519.

    Choo, Y.M. and M.T. Hamann* 2007. An improved Pictet-Spengler Condensation: A convenient synthetic route to bioactive manzamine derivatives. Link Heterocycles 71 (2), 245-252.

    Hua, H.M., J. Peng, D.C. Dunbar, R.F. Schinazi, A.G. de Castro Andrews, C. Cuevas, L.F. Garcia-Fernandez, M. Kelly and M.T. Hamann* 2007 Batzelladine alkaloids from the Caribbean sponge sponge Monanchora unguifera and the significant activities against HIV-1 AIDS opportunistic infectious pathogens. Link Tetrahedron 63, 11179-11188.

    Hamann, M.T., D. Alonso, E. Martin-Aparacio, A. Fuertes, M. J. Perez-Puerto, A. Castro, S. Morales, M. L. Navarro, M. del Monte-Millán, M. Medina, H. Pennaka, A. Balaiah, J. Peng, J. Cook, S. Wahyuono, and A. Martinez*  2007.  Glycogen Synthase Kinase-3 (GSK-3) Inhibitory Activity and Structure-Activity Relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease. Link Journal of Natural Products 70, 1397-1405.

    Winkler, J.D.*, A.T. Londregan and M.T. Hamann* 2007. Synthetic modification of manzamine A via Grubbs metathesis. Novel structures with enhanced antibacterial and antiprotozoal properties. Link Organic Letters 9(22), 4467-4469,

    Shilabin, A.G., N. Kasanah, D.E. Wedge and M.T. Hamann 2007. Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: Semisynthetic modifications and antifungal lead-exploration studies. Link Journal of Medicinal Chemistry 50, 4340-4350.

    Mayer, A.M.S.*, A.D. Rodriguez, R.G.S. Berlink and M.T, Hamann 2007. Marine pharmacology in 2003-2004: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action. Link Comparative Biochemistry and Physiology, Part C 145. 61. 553-581.

    Hamann, M.T., R. Hill and S. Roggo 2007. Marine Natural Products. Key advances to the practical application of this resource in drug development. Link Chimia 61(6). 313-321.

    Hamann, M.T. 2007. The manzamines as an example of the unique structural classes available for the discovery and optimization of infectious disease controls based on marine natural products. Link Current Pharmaceutical Design 13. 653-660.

    Gul, W., N.L. Hammond, M. Yousaf, J.J. Bowling, R.F. Schinazi, S.S. Wirtz, A.G. de Castro Andrews, C. Cuevas and M.T. Hamann* 2006 Modification at C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacteria, and tumor cell activity. Link Bioorganic and Medicinal Chemistry 14, 8495-8505.

    Winkler, J.,* A. Londregan, J. Ragains, M.T. Hamann*  2006.  Synthesis and Biological Evaluation of Manzamine Analogues. Link Organic Letters 8, 3407-3409.

    Hamann, M.T. 2006. Book Review of: Methods in Biotechnology, Natural Products Isolation, Second Edition. Edited by Satyajit D. Sarker, Zahid Latif and Alexander Gray. Link Journal of Medicinal Chemistry 49, 2666.

    Mohammed, R., J. Peng, M. Kelly and M.T. Hamann* 2006 New cyclic heptapeptides from the Jamaican sponge Stylissa caribica lennert & Van Sorest, 1998 (Halichondrida: Dictyonellidae) Journal of Natural Products. 69, 1729-1744.

    Diers, J. A., J.J. Bowling, S.O. Duke, S. Wahyuono, M. Kelly and M.T. Hamann*  2006. Zebra Mussel Antifouling Activity of the Marine Natural Product Aaptamine and Analogs. Link Marine Biotechnology 8(4), 366-372.

    Quinn, N.,* D. Gochfeld, M.T. Hamann, M. Slattery, L. Walker and B. Kojis  2006. Documenting and conserving biodiversity in Jamaican coral reefs while exploring for pharmacologically interesting natural products. Link Proceedings of the 10th International Coral Reef Symposium 800-809.

    Rao, K.V., M.S. Donia, J. Peng, E. Garcia-Palomero, D. Alonso, A. Martinez, M. Medina, S.G. Franzblau, B.L. Tekwani, S.I. Khan, S. Wahyuono, K.L. Willett and M.T. Hamann*  2006. Manzamine B and E and Ircinal A Related Alkaloids from an Indonesian Acanthostrongylophora Sponge and Their Activity against Infectious, Tropical Parasitic, and Alzheimer's Diseases. Link Journal of Natural Products. 69, 1034-1040.

    Khalifa, K.,* S. Ahmed, M. Mesbah, D. Yousaf and M.T. Hamann 2006. Quantitative determination of latrunculins A and B in the Red Sea sponge Negombata magnifica by high performance liquid chromatography. Link Journal of Chromatography B 832(1), 47-51.

    Peng, J., N. Kasanah C.E. Stanley, J. Chadwick, F.R. Fronczek and M.T. Hamann* 2006. Microbial metabolism studies of cyanthiwigin B and synergetic antibiotic effects. Link Journal of Natural Products. 69(5), 727-730.

    Bashyal, B., P. Desai, K.V. Rao, M.T. Hamann, B.A. Avery, J.K. Reed and M.A. Avery* 2006. Terpenes from Eunicea laciniata and Plexaurella nutans. Link Journal of Chemical Research. 8, 165-167.

    Robert, F., Q.G. Hong, M. Donia, W.C. Merrick, M.T. Hamann and J. Pelletier* 2006. Chlorolissoclimides: New inhibitors of eukaryotic protein synthesis. Link RNA 12(5), 717-724.

    Winkler, J.D.,* A.T. Londregan and M.T. Hamann* 2006. Antimalarial activity of a new family of analogues of manzamine A. Link Organic Letters 8 (12), 2591-2594.

    Mohammed, R., J. Peng , M. Kelly, M.T. Hamann. 2006. Cyclic Heptapeptides from the Jamaican Sponge Stylissa caribica. Link Journal of Natural Products. 69(12):1739-1744.

    Gul, W., N.L. Hammond , M.Yousaf, J.J. Bowling, R.F. Schinazi, S.S. Wirtz , Andrews G. de Castro , C. Cuevas, M.T. Hamann. 2006. Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity. Link Bioorganic & Medicinal Chemistry. 14(24):8495-505.

    Rao KV, M.S. Donia , J. Peng, E. Garcia-Palomero, D. Alonso, A. Martinez, M. Medina, S.G. Franzblau, B.L. Tekwani, S.I. Khan, S. Wahyuono, K.L. Willett, M.T. Hamann. 2006. Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases. Journal of Natural Products. 69(7):1034-40. Link

    Khalifa, K., S. Ahmed, M. Mesbah, D. Yousaf, M.T. Hamann. 2006. Quantitative determination of latrunculins A and B in the Red Sea sponge Negombata magnifica by high performance liquid chromatography.  Journal of Chromatography B. 832: 47-51. Link

    Winkler, J., A. Londregan, J. Ragains, M.T. Hamann.  2006.  Synthesis and Biological Evaluation of Manzamine Analogues.  Organic Letters. Jul 20;8(15):3407-9. Link

    Winkler, J., A. Londregan, M.T. Hamann.  2006.  Antimalarial activity of a new family of analogues of manzamine A.  Organic Letters. 8(12):2591-4. Link

    Peng, J., N. Kasanah, C.E. Stanley, J. Chadwick, F.R. Fronczek, M.T. Hamann. 2006. Microbial metabolism studies of cyanthiwigin B and synergetic antibiotic effects. Journal of Natural Products. 69(5):727-30. Link

    Diers, J.A., J.J. Bowling, S.O. Duke, S. Wahyuono, M. Kelly, M.T. Hamann. 2006. Zebra mussel antifouling activity of the marine natural product aaptamine and analogs. Marine Biotechnology. 8(4):366-72. Link

    F. Robert, H.Q. Gao, M. Donia, W.C. Merrick, M.T. Hamann, J. Pelletier. 2006. Chlorolissoclimides: new inhibitors of eukaryotic protein synthesis. RNA. 12(5):717-25. Link

    Kasanah, N. and M.T. Hamann. 2005. SPK-843 Aparts/Kaken. Current Opinion in Investigational Drugs.  6(8): 845-853. Link

    Gul, W. and M.T. Hamann. 2005. Indole alkaloid marine natural products: an established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases. Life Sciences. 78(5):442-53. Link

    Hu, J.F., J. Peng and M.T. Hamann. 2005. Bromopyrrole alkaloids from the Jamaican sponge Didiscus oxeata. Journal of Chemical Research. 7, 427-428. Link

    Bourel, L., K.V. Rao, M.T. Hamann and A. Ganesan. 2005. Solid-phase total synthesis of kahalalide A and related analogues. Journal of Medicinal Chemistry. 48(5), 1330-1335. Link

    Mayer, A..S. and M.T. Hamann. 2005. Marine Pharmacology in 2001-2002: compounds with anthelminthic, antibacterial, anticoagulant, antidiabetic, antifungal, antiinflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis and antiviral activities; affecting the cardiovascular, endocrine, immune and nervous systems and other miscellaneous mechanisms of action. Comparative Biochemistry and Physiology, Part C Toxicology and Pharmacology. 140(3-4): 265-86. Link

    Enticknap, J.J., R. Thompson, O. Peraud, J.E. Lohr, M.T. Hamann and R.T. Hill. 2004. Molecular analysis of a Florida Keys sponge: Implications for natural products discovery. Marine Biotechnology 6, 288-293.

    Pennaka, H.K., M. Yousaf, K.V. Rao, M. Kelly, R.T. Hill, S.G. Franzblau, M.T. Hamann 2004. Solving limited supplies of marine pharmaceuticals through the rational and high-throughput modification of high-yielding marine natural product scaffolds. Marine Biotechnology 6, S273-S280.

    Kasanah, N., K.V. Rao, M. Yousaf, D.E. Wedge, R.T. Hill and M.T. Hamann 2004. Biotransformation studies of the manzamine alkaloids. Marine Biotechnology S268-S272.

    Hua, H.H., J. Peng, F.R. Fronczek, M. Kelly and M.T. Hamann 2004. Crystallographic and NMR studies of anti-infective tricyclic guanidine alkaloids from the sponge Monanchora unguifera. Bioorganic & Medicinal Chemistry 12, 6461-6464. Link

    Diers, J.A., H.K. Pennaka, J. Peng, J.J. Bowling, S.O. Duke, J.A. Schetz, and M.T. Hamann 2004. Structural activity relationship studies of zebra mussel antifouling and antimicrobial agents from Verongid sponges. Journal of Natural Products 67, 2117-2120. Link

    Hamann, M.T. 2004. Technology evaluation: Kahalalide F, PharmaMar. Current Opinion in Molecular Therapeutics 6(6) 657-665.

    Kasanah, N. and M.T. Hamann 2004. Development of antibiotics and the future of marine microorganisms to stem the tide of antibiotic resistance. Current Opinion in Molecular Therapeutics 5(8), 827-837.

    Rao, K.V., N. Kasanah, S. Wahyuono, B.L. Tekwani, R.F. Schinazi and M.T. Hamann 2004. Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases. Journal of Natural Products (Special memorial edition for PJ. Scheuer and J. Faulkner) 67, 1314-1318. Link

    Yousaf, M., N.L. Hammond, J. Peng, S. Wahyuono, K.A. McIntosh, W.N. Charman, A.M.S. Mayer, and M.T. Hamann, 2004. New Manzamine Alkaloids from an Indo-Pacific Sponge; Pharmacokinetics, Oral Availability and the Significant Activity of Several Manzamines Against HIV-I, AIDS Opportunistic Infections and Inflammatory Diseases. The Journal of Medicinal Chemistry 47, 3512-3517. Link

    Mayer, A.M.S. and M.T. Hamann 2004. Marine Pharmacology in 2000: compounds with antibacterial, anticoagulant, antifungal, anthelmintic, antiinflammatory, antiplatelet, antiprotozoal and antiviral activities; affecting the cardiovascular, endocrine, immune and nervous systems and other miscellaneous mechanisms of action. Marine Biotechnology 6, 37-52.

    Peng, J., M. Avery and M.T. Hamann 2003. Cyanthiwigin AC and AD, Two Novel Diterpene Skeletons from the Jamaican Sponge Myrmekioderma styx. Organic Letters 5, 4575-4578. Link

    Peng, J., J.F. Hu; A.B. Kazi, Z. Li, M. Avery, O. Peraud, R. Hill, S.G. Franzblau, F. Zhang, R.F. Schinazi, S.S. Wirtz, P. Tharnish, M. Kelly, S. Wahyuono and M.T. Hamann 2003. Manadomanzamines A and B, a novel alkaloid ring system with potent activity against Mycobacteria and HIV-1Link . Journal of the American Chemical Society 125, 13382-13386.

    Donia, M., M.T. Hamann 2003. Marine natural products and their potential applications as antiinfective agents Link. The Lancet Infectious Diseases 3, 338-348.

    Khalil, A.; El-Sayed, K.; Belal, F.; Khalil, N. Y.; Hamann, M. 2003. Spectrofluorimetric determination of manzamine A in spiked human urine and plasma. Link Pharmazie 58, 385-388.

    Hamann, M.T. 2001. Book Review of: Bioactive compounds from natural sources: isolation, characterization and biological properties. Edited by Corrado Tringall. Journal of Natural Products. 64, 1382.

    Rao, K.V., B.D. Santarsiero, A.D. Mesecar, R.F. Schinazi, B.L. Tekwani and M.T. Hamann. 2003. New manzamine alkaloids with significant activity against infectious and tropical parasitic diseases from an Indonesia sponge.Link Journal of Natural Products. 66(6), 823-828.

    Peng, J., J.F. Hu; A.B. Kazi, S.G. Franzblau, F. Zhang, R.F. Schinazi, S.S. Wirtz, P. Tharnish, M. Kelly and M.T. Hamann. 2003. Manadomanzamines A and B, a novel antimycobacterial manzamine ring system from an Indonesian sponge Petrosiidae sp. Journal of the American Chemical Society. 125(44), 13382-13386.

    Gochfeld, D.J., K.A. El Sayed P. Bartyzel, X. Shen, S.P. Wilkins, J.K. Zjawiony, R.F. Schinazi, S. Schlueter-Wirtz P.M. Tharnish and M.T. Hamann. 2003. Structurally diverse marine natural products as anti-HIV agents. Mini Reviews in Medicinal Chemistry. 3(5), 401-424.

    Takamatsu, S., T.W. Hodges, I. Rajbhandari, W.H. Gerwick, M.T. Hamann and D.G. Nagle. 2003. Marine natural products as novel antioxidant prototypes. Link. Journal of Natural Products. 66(5), 605-608.

    Duncan, C.J., F.R. Fronczek, M. Cuendet, J.M. Pezzuto, R.G. Menta, M.T. Hamann and S.A Ross 2003. Chemical and biological investigation of the fungus Link Pulveroboletus ravenelii. The Journal of Natural Products. 66, 103-107.

    Peng, J., X. Shen, K.A. El Sayed, D.C. Dunbar, T.L. Perry, S.P. Wilkins M. Prinsen, S. Bobzin, J. Huesing, R. Camp, D, Krupa, M.A. Wideman and M.T. Hamann 2003. Marine natural products as agrochemical agents Link. The Journal of Agricultural and Food Chemistry. 51(8), 2246-2252.

    Hamann, M.T. 2003. Enhancing marine natural product structural diversity and bioactivity through semisynthesis and biocatalysis . Current Pharmaceutical Design. 9, 879-889.

    Orabi, K.Y., K.A. El Sayed, M.T. Hamann, D.C. Dunbar, M.S. Al-Said, T. Higa and M. Kelly 2002. Araguspongines K and L, new bioactive bis-1-oxaquinolizidine N-oxide alkaloids from Red Sea specimens of Xestospongia exigua. The Journal of Natural Products. 65, 1782-1785.

    Mayer, A.M.S. and M.T. Hamann 2002. Marine Pharmacology in 1999: compounds with antibacterial, anticoagulant, antifungal, anthelmintic, antiinflammatory, antiplatelet, antiprotozoal and antiviral activities; affecting the cardiovascular, endocrine, immune and nervous systems and other miscellaneous mechanisms of action. Comparative Biochemistry and Physiology, Part C. 132, 315-339.

    Kasanah, N., M. Yousaf; K.V. Rao; D. Wedge; and M.T. Hamann. 2002. The biocatalytic conversion of 8-hydroxymanzamine A to manzamine A using Fusarium solani. Tetrahedron letters. 44, 1291-1293.

    Wilkins, S.P., A.J. Blum, T.J. Rutland, A. Wierzbicki; M. Kelly and M.T. Hamann 2002. Isolation of an antifreeze peptide from the Antarctic sponge Homaxinella balfourensis. Cellular and Molecular Life Sciences. 59, 2210-2215.

    El Sayed, K.A., M. Yousaf, M.T. Hamann, M.A. Avery, M. Kelly and P. Wipf. 2002. Microbial and chemical transformation studies of the bioactive marine sesquiterpene S-(+)-curcuphenol and curcudiol isolated from the Deep Reef Collection of the Jamaican sponge Didiscus oxeata. The Journal of Natural Products. 65, 1547-1553.

    Hoye, T.R., S.E.N. Ayyad, B.M. Eklov, N.E. Hashish, W. T. Shier, K.A. El Sayed and M.T. Hamann. 2002. Toward computing natural product structures: 16-epi-latrunculin B, a new stereoisomer of the potent actin polymerization inhibitor, latrunculin B. The Journal of the American Chemical Society. 124, 7405-7410.

    Peng, J., K., Walsh, V. Weedman, and M.T. Hamann. 2002. The new bioactive diterpenes cyanthiwigin E-AA from the Jamaican sponge Myrmekioderma styx. Tetrahedron. 58, 7809-7819.

    Peng, J., S.G. Franzblau, F. Zhang and M.T. Hamann. 2002. Novel sesquiterpenes and a lactone from the Jamaican sponge Myrmekioderma styx. Tetrahedron Letters. 43, 9699-9702.

    Hu, J.F., M. Kelly, M.T. Hamann . 2002. 26-Nor-25-isopropyl-ergosta-5,7,22E-trien-3a-ol, a new C29 sterol from the Jamaican sponge Agelas sceptrum. Steroids. 67, 743-747.

    Yousaf, M.; K.A. El Sayed, K.V. Rao, C.W. Lim, J. Hu, M. Kelly, S.G. Franzblau, F. Zhang, O. Peraud, R.T. Hill and M.T. Hamann, 2002. 12,34 Oxamanzamines, novel biocatalytic and natural products from manzamine producing Indo-Pacific sponges. Tetrahedron. 58, 7397-7402.

    El Sayed, K.A., K. Y. Orabi, D.C. Dunbar, M.T. Hamann, M.A. Avery, Y.A. Sabnis, J.S. Mossa and F.S. El-Feraly 2002. Transformation of lactone to lactam in sarcophine and antimalarial activity of the resulting N-substituted azasarcophines. Tetrahedron. 58, 3699-3708.

    Hu, J.F., J.A. Schetz, M. Kelly, J.N. Peng, K.K.H. Ang, H. Flotow, C.Y. Leong, S.B. Ng, A.D. Buss, S.P. Wilkins, M.T. Hamann . 2002 New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea. Journal of Natural Products. 65, 476-480.

    Hu, J.F., M. Kelly, H.F. Gao, M.T. Hamann 2001. Plakortides I-L, four new cyclic peroxides from an undescribed Jamaican sponge Plakortis sp. (Homosclerophorida, Plakinidae). Tetrahedron. 57, 9379-9383.

    Perry, T.P., A. Dickerson, A.A. Khan, R.K. Kondru, D.N. Beratan, P. Wipf, M. Kelly and M.T. Hamann 2001. New peroxylactones from a Jamaican sponge Plakinastrella onkodes, with inhibitory activity against the AIDS opportunistic parasitic infection Toxoplasma gondii. Tetrahedron. 57, 1483-1487.

    Gochfeld, D.J. and M.T. Hamann 2001. The isolation and biological evaluation of filiformin, plakortide F and plakortone G from the Caribbean sponge Plakortis sp. The Journal of Natural Products. 64, 1477-1479.

    El Sayed, K.A., M.T. Hamann , N.E. Hashish, T. Shier, and M. Kelly 2001. Antimalarial, antiviral and antitoxoplasmosis norsesterterpene peroxide acids from a Red Sea sponge Diacarnus erythraeanus. Journal of Natural Products. 64, 522-524.

    El Sayed, K.A., M. Kelly, U.A.K. Kara, K.K.H. Ang and M.T. Hamann 2001. New manzamine alkaloids with potent activity against infectious disease. Journal of the American Chemical Society. 123, 1804-1808.

    Hu, J.F., Y. Hu, B. Zhao, X.Z. Feng and M.T. Hamann 2001. New eudesmenoic acid methyl ester from Artemisia selengensis. Spectroscopy Letters. 34(1). 75-81.

    Dunbar, D.C., J.M. Rimoldi, A.M. Clark, M. Kelly and M.T. Hamann 2000. Anti-cryptococcal and nitric oxide synthase inhibitory imidazole alkaloids from the calcareous sponge Leucetta cf chagosensis. Tetrahedron. 56, 8795-8798.

    Chatterjee, P. S.A. Kouzi, J.M. Pezzuto and M.T. Hamann 2000. Biotransformation of the antimelanoma agent betulinic acid by Bacillus megaterium ATTC 13368. Applied and Environmental Microbiology. 66, 3850-3855.

    Ang, K.K.H., M.J. Holmes, T. Higa, M.T. Hamann and U.A.K. Kara 2000. In vivo antimalarial activity of the beta-carboline alkaloid manzamine A. Antimicrobial Agents and Chemotherapy. 44, 1645-1649.

    El Sayed, K.A., P. Bartyzel, X. Shen, T.L. Perry, J.K. Zjawiony, and M.T. Hamann 2000. Marine natural products as antituberculosis agents. Tetrahedron. 56, 949-953.

    Ross, S.A., J.D. Weete, R.F. Schinazi, S.S. Wirtz, P. Tharnish, P.J. Scheuer and M.T. Hamann 2000. Mololipids, a new series of anti-HIV bromotyramine-derived compounds from a sponge of the order Verongida. Journal of Natural Products. 63, 501-503.

    Cichewicz, R.H., S.A. Kouzi and M.T. Hamann 2000. Dimerization of resveratrol by the grapevine pathogen Botrytis cinerea. Journal of Natural Products. 63, 29-3314.

    Demirci, B., Baser, K.H.C., Demirci, F. and M.T. Hamann 2000. New caryophyllene derivatives from Betula litwinowii. Journal of Natural Products. 63, 902-904.

    Kouzi, S.A., P. Chatterjee, J.M. Pezzuto and M.T. Hamann 2000. Microbial transformation of the antimelanoma agent betulinic acid. Journal of Natural Products. 63, 1653-1657.

    Baser, K.H.C., Demirci, B., Demirci, F., Bedir, E., Weyerstahl, P., Marschall, H., Duman, H., Aytac, Z., and M.T. Hamann 2000. A new bisabolene derivative from the essential oil of Prangos uechtritzii fruits. Planta Medica. 66, 674-677.

    El Sayed, K.A., A.M.S. Mayer, M. Kelly and M.T. Hamann 1999. The biocatalytic transformation of furan to amide in the bioactive marine natural product palinurin. Journal of Organic Chemistry. 64, 9258-9260.

    Shen, X., S.B. Krasnoff, S. Lu, D.C. Dunbar, J. O'Neal, B.G. Turgeon, O.C. Yoder, D.M. Gibson and M.T. Hamann . 1999. Characterization of 6-epi-3-anhydroophiobolin B from Cochliobolus heterostrophus. Journal of Natural Products. 62, 895-897.

    H. Gao, M. Kelly, M.T. Hamann 1999. Bromotyrosine-derived metabolites from the sponge Aiolochroia crassa. Tetrahedron. 55, 9717-9726.

    Pennings, S.K. , V.J. Paul, D.C. Dunbar, M.T. Hamann, W.A. Lumbang, B. Novack and R.S. Jacobs. 1999. Unpalatable compounds in the marine gastropod Dolabella auricularia: distribution and effect on diet. The Journal of Chemical Ecology. 25, 735-755.

    Shen, X., T.L. Perry, D.C. Dunbar, M. Kelly-Borges and M.T. Hamann . 1998. Debromosceptrin, an alkaloid characterized using 15N NMR spectroscopy from the Caribbean sponge Agelas sp. Journal of Natural Products. 61, 1302-1303.

    J.K. Zjawiony , P. Bartyzel and M.T. Hamann. 1998. Chemistry of puupehenone: 1,6-conjugate addition to its quinone-methide system. Journal of Natural Products. 61, 1502-1508.

    El Sayed, K.A. , M.T. Hamann, H.A. Abd El-Rahman and A.M Zaghloul. 1998. New pyrrole alkaloids from Solanum sodomaeum. Journal of Natural Products. 61, 848-850.

    El Sayed, K.A., M.T. Hamann , C.A. Waddling, C. Jensen, S.K. Lee, C.A. Dunstan and J.M Pezzuto. 1998. Structurally novel bioconversion products of the marine natural product sarcophine effectively inhibit JB6 cell transformation. Journal of Organic Chemistry. 63, 7449-7455.

    Bryan, P.J., J.B. McClintock and M.T. Hamann. 1997. Behavioral and chemical defenses of marine prosobranch gastropod Calliostoma canaliculatum in response to sympatric seastars. The Journal of Chemical Ecology. 23, 645-658

    El Sayed, K.A., D.C. Dunbar, T.L. Perry, S.P. Wilkins, M.T. Hamann , J.T. Greenplate and Margaret A. Wideman. 1997. Marine natural products as prototype insecticidal agents. Journal of Agricultural and Food Chemistry. 45, 2735-2739.

    Ross, S.A., K.A. El Sayed , M.A. El Sohly, M.T. Hamann, O.B. Abdel-Halim, A.F. Ahmed and M.M. Ahmed. 1997. Phytochemical analysis of Geigeria alata and Francoeuria crispa essential oils. Plant Medica. 63, 479-482.

    Slattery, M , M.T. Hamann, J.B. McClintock, T.L. Perry, M.P. Puglisi, W.Y. Yoshida. 1997. Ecological roles for water-borne metabolites from Antarctic soft corals. Marine Ecology Progress Series. 161, 133-144.

    Reese, M.T., N.K. Gulavita, Y. Nakao, M.T. Hamann, W.Y. Yoshida, S.J. Coval and P.J. Scheuer . 1996. Kulolide: A Cytotoxic Depsipeptide from a Cephalaspidean mollusk, Philinopsis speciosa. Journal of the American Chemical Society. 118, 11081-11084.

    Hamann, M.T., C.S. Otto, P.J. Scheuer and D.C. Dunbar 1996. Kahalalides, bioactive depsipeptides from the sacoglossan mollusk Elysia rufescens and the green alga Bryopsis sp. Journal of Organic Chemistry. 61, 6594-6600.

    Wesson, K.J. and M.T. Hamann . 1996. Keenamide A, a bioactive cyclic peptide from the marine mollusk Pleurobranchus forskalii. Journal of Natural Products. 59, 629-631.

    El Sayed, K.A. and M.T. Hamann . 1996. A new norcembranoid dimer from the Red Sea soft coral Sinularia gardineri. Journal of Natural Products. 59, 687-689.

    El Sayed, K.A., D.C. Dunbar, D.K. Goins, C.R. Cordova, T.L. Perry, K.J. Wesson and M.T. Hamann . 1996. The marine environment: A resource for prototype antimalarial agents. Journal of Natural Toxins. 5, 261-285.

    Hamann, M.T., K.N. Harrison, A.R. Carroll and P.J. Scheuer . 1996. Nui-inoalides, briarane diterpenes from a Micronesian gorgonian. Heterocycles. 42, 325-331.

    Nasu, S.S., B.K.S. Yeung, M. Kelly-Borges, M.T. Hamann, P.J. Scheuer and D.K. Goins. 1995. Bioactive sesquiterpenes from two Hawaiian sponges of the order Hyrtios. Journal of Organic Chemistry. 60, 7290-7292.

    Yeung, B.K.S., M. Kelly-Borges, M.T. Hamann and P.J. Scheuer . 1994. Hapaioside: a pregnane glycoside from the sponge Cribrochalina olemda. Tetrahedron. 50, 12593-12598.

    McClintock, J.B. , B.J. Baker, M.T. Hamann, W. Yoshida, M. Slattery, J. Heine, P.J. Bryan, G. Jayatilaka and B. Moon. 1994. Homarine as a feeding deterrent in the common shallow-water Antarctic lamellarian gastropod Marseniopsis mollis: a rare example of chemical defense in a marine prosobranch. Journal of Chemical Ecology. 20, 2539-2549.

    McClintock, J.B. , B.J. Baker, M.T. Hamann, M. Slattery, R.W. Kopitzke and J. Heine. 1994. Chemotactic tube foot Responses of the spongivorous sea star Perknaster fuscus to organic extracts from Antarctic sponges. Journal of Chemical Ecology. 20, 859-870.

    Baker, B. J. , R.W. Kopitzke, M.T. Hamann and J.B. McClintock. 1993. Chemical ecology of Antarctic marine invertebrates in McMurdo Sound, Antarctica: chemical aspects. Antarctic Journal. U.S. 28, 132-133.

    Hamann, M.T., P.J. Scheuer and M. Kelly-Borges. 1993. Biogenetically diverse, bioactive constituents of a sponge, order Verongida: bromotyramines and sesquiterpene-shikimate derived metabolites. Journal of Organic Chemistry 58, 6565-6569.

    Hamann, M.T. and P.J. Scheuer . 1993. Kahalalide F, a bioactive depsipeptide from the sacoglossan mollusk Elysia rufescens and the green alga Bryopsis sp. Journal of the American Chemical Society. 115, 5825-5826.

    Hamann, M.T. 1992. Biologically active constituents of some marine invertebrates. CA120(19): 240579K. Ph. D. Dissertation.

    Hamann, M.T. and P. J. Scheuer . 1991. Cyanopuupehenol, an antiviral metabolite of a sponge of the order Verongida. Tetrahedron Letters. 32, 5671-5672.

     

     

    Book Chapters

    Jin Feng Hu, Russell, Hill, Michelle Kelly and Mark T. Hamann. 2003. The Marine b-carboline Containing Alkaloids called the Manzamines in: "The Alkaloids: Biology and Chemistry." Volume 60, 205-283. CRC Press.

    Nagle, D. G., G. N.Sultana, K. K. Schrader, C. F. Hossain, R. Stanikunaite, M. T. Hamann, I. Rajbandari. 2003. Secondary metabolites from plants and marine organisms as selective anti-cyanobacterial agents in: American Chemical Society Symposium Series.

    K.A. ElSayed, D.C. Dunbar, P. Bartzel, J.K. Zjawiony, W. Day, and M.T. Hamann. 1999. Marine Natural Products as Leads to Develop New Drugs and Insecticides in: Biologically Active Natural Products: Pharmaceuticals. CRC Press.