Representative Publications
K. A. ElSayed,
D. C. Dunbar, P. Bartyzel, J. K.
Zjawiony, W. Day, and M.T. Hamann, "Marine Natural Products as
Leads to Develop New Drugs and Insecticides", in Biologically Active Natural Products:
Agrochemicals and Pharmaceuticals, CRC Press, Boca Raton,
FL, 2000, 233-252.
Khalid A. El-Sayed, Piotr Bartyzel, Xiaoyu Shen, Tony L. Perry, Jordan K. Zjawiony, and Mark T.
Hamann, "Marine Natural Products as Antituberculosis Agents," Tetrahedron, 56, 2000, 949-953.
I. Katsuyama and J.K.
Zjawiony,
"Theoretical and Experimental Aspects of Bromination of Sampangine,"
Chem. Letters, 2000, 568-569.
F. E. Dayan, A.
C. Vincent, J. G. Romagni, S. N. Allen, S. O. Duke, M. V. Duke, J. J.
Bowling, and J.
K. Zjawiony,
“Amino-and Urea-substituted Thiazoles Inhibit Photosynthetic Electron
Transfer”, J.
Agric. Food Chem., 2000,48, 3689-3693.
I. Katsuyama, A.
A. Khalil, J. Ren, J.
K. Zjawiony,
“The Identification, Mechanism, and Improved Synthesis of a New and
Unique Heterocyclic System with a Fused Imidazole Ring”, Heterocycles, 2001, 54,721-726.
Xing-Cong Li,
Alpana S. Joshi, Bo Tan, Hala N. ElSohly, Larry A. Walker, Jordan K. Zjawiony, and Daneel
Ferreira, “Absolute Configuration, Conformation and Chiral Properties
of Flavanone-(3-8’’)-flavone Biflavanoids from Rheedia acuminata”, Tetrahedron, 2002, 58, 8709-8717.
Isamu Katsuyama,
H. Fahmy, and J.
K. Zjawiony,
Sherief I. Khalifa, Raouf W. Kilada, Takao Konoshima, Midori Takasaki,
and Harakuni Tokuda, “Semisynthesis of New Sarcophine Derivatives with
Chemopreventive Activity”, J.
Nat. Prod., 2002, 65, 1809-1814.
Hesham Fahmy, Jordan
K. Zjawiony,
Sheiref Khalifa and Frank Fronczek, „A Semisynthetic Analog of the
Cembranoid Sarcophine”, Acta
Cryst., 2003, C59, o85-o87.
Gochfeld, D.J.,
K.A. El Sayed, M. Yousaf, J.F. Hu, P. Bartyzel, D.C. Dunbar, S.P.
Wilkins, J.K.
Zjawiony,
R.F. Schinazi, S.Schlueter-Wirtz P.M. Tharnish and M.T. Hamann, “Marine
Natural Products as Lead Anti-HIV Agents, Mini
Rev. Med. Chem., 2003, 3, 401-425.
Hesham T.Y.
Fahmy, Sherif A.F. Rostom, Manal N. Saudi, Jordan
K. Zjawiony,
David J. Robins. Synthesis and in-vitro evaluation of the anticancer
activity of novel fluorinated thiazolo[4,5-d]pyrimidines. Arch.
Pharm. Pharm. Med. Chem., 2003, 336, 216-225.
I. Katsuyama,
A.A. Khalil, C. Dunbar, and J.
K. Zjawiony,
“Concentration-Dependent Variation in 1H-NMR Chemical Shifts of
Aromatic Protons in Sampangine Derivatives”, Spectroscopy
Letters., 2003, 36(5 & 6),
477-485.
H. Fahmy, S.I.
Khalifa, T. Konoshima, J.
K. Zjawiony.
“An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene-15R(),
16-diol, a Cembranoid of Marine Origin with a Potent Cancer
Chemopreventive Activity”, Marine
Drugs, 2004, 1, 1-7.
J. Stewart, I.
Katsuyama, H. Fahmy, F.R. Fronczek, and J.K.
Zjawiony,”
A Direct Synthesis of 3,5-Dibromo-O-Methyl-L-Tyrosine”, Synthetic
Commun., 2004, 34(3), 547-555.
Charles Chavkin,
Sumit Sud, Wenzhen Jin, Jeremy Stewart, Jordan
K. Zjawiony,
Daniel J. Siebert, Beth Ann Toth, Sandra J. Hufeisen, and Bryan L.
Roth, “Salvinorin A, an Active Component of the Hallucinogenic Sage
Salvia divinorum, is a Highly Efficacious Kappa Opioid Receptor
Agonist: Structural and Functional Considerations”, J.
Pharmacol. Exp. Ther., 2004, 308(3), 1197-1203.
J.
K. Zjawiony,
“Biologically Active Compounds from Aphyllophorales (Polypore) Fungi”, J.
Nat. Prod., 2004, 67, 300-310.
A. Slominski, J.
Zjawiony,
J. Wortsman, I. Semak, J. Stewart, A Pisarchik, T. Sweatman, J. Marcos,
C. Dunbar, R.C. Tuckey. “A Novel Pathway for Sequential Transformation
of 7-Dehydrocholesterol and Expression of the P450scc System in
Mammalian Skin”, Eur.
J. Biochem., 2004, 271, 4178-4188.
F. Yang, P. D.
Mosier, R. B. Westkaemper, J. Stewart, J.
K. Zjawiony,
T. A. Vortherms, D. J. Sheffler, B. L. Roth. “Identification of the
Molecular Mechanism by which the Diterpenoid Salvinorin A Binds to
k-Opioid Receptor”, Biochemistry, 2005, 44(24), 8643-8651.
A. Slominski, I.
Sermak, J.
Zjawiony,
J. Wortsman, Wei Li, A. Szczesniewski, R.C. Tuckey. “The Cytochrome
P450scc system Opens an Alternate Pathway of Vitamin D3 Metabolism”, FEBS
Journal, 2005, 272, 4080-4090.
M. A. Ansonoff,
J. Zhang, T. Czyzyk, R. B Rothman, J. Stewart, J.
Zjawiony,
D. J. Siebert, B. L. Roth, J. E. Pintar.” In vivo Actions of Salvinorin
A are Mediated by the KOR-1 Gene”, 2005.
A. Slominski, J. Zjawiony, W. Li, J. Wortsman, I.
Semak, B. Zbytek, R. C. Tuckey. "Enzymatic metabolism of
ergosterol by cytochrome P450scc (CYP11A1) to biologically active
17,24-dihydroxyergosterol.", Chemistry
and Biology, 2005.
R. Capasso, F.
Borrelli, F. Capasso, D. J. Siebert, D. J. Stewart, J. K. Zjawiony, and A. A. Izzo. “The
hallucinogen herb Salvia divinorum and its active ingredient salvinorin
A inhibit enteric cholinergic transmission in the guinea pig
ileum”, Neurogastroenterology
and Motilit, 2006. 18, 69-75.
Andrzej Slominski, Igor Semak, Jacobo Wortsman, Jordan Zjawiony, Wei Li, Blazej Zbytek, Robert C. Tuckey, “ An Alternate Pathway of Vitamin D2 Metabolism: Cytochrome P450scc (CYP11A1) Mediated Conversion to 20-Hydroxyvitamin D2 and 17,20-Dihydroxyvitamin D2”, FEBS Journal, 2006, 273, 2891-2901.
D. Jeremy Stewart, Hesham Fahmy, Bryan L. Roth, Feng Yan, and Jordan K. Zjawiony. “Bioisosteric Modifications of Salvinorin A, a Potent and Selective Kappa-Opioid Receptor Agonist”, Arzneimittel-Forschung Drug Research, 2006, 269-275
Wentao Jin and Jordan K. Zjawiony. “5-Alkylresorcinols from Merulius incarnatus”, J. Nat. Prod., 2006, 69, 704-706.
Michael A. Ansonoff, Jiwen Zhang, Traci Czyzyk, Richard B. Rothman, Jeremy Stewart, Heng Xu, Jordan Zjawiony, Daniel J. Siebert, Feng Yan, Bryan L. Roth, and John E. Pintar. “Antinociceptive and Hypothermic Effects of Salvinorin A Are Abolished in a Novel Strain of k-Opioid Receptor-1 Knockout Mice”, J. Pharmacol. Exp. Ther., 2006, 318, 641-648.
Jose-Luis Giner, David J. Kiemle, Lukasz Kutrzeba and Jordan Zjawiony. “Unambiguous NMR spectral assignments of salvinorin A”, Magn. Reson. Chem., 2007, 45, 351-354.
Jordan K. Zjawiony. “Antitubercular Activity of Mushrooms (Basidiomycetes) and Their Metabolites”, Nat. Prod. Comm., 2007, 2, 315-318.
Ruslan V. Bikbulatov, Feng Yan, Bryan L. Roth, and Jordan K. Zjawiony. “Convenient Synthesis and in Vitro Pharmacological Activity of 2-Thioanalogs of Salvinorin A and B”, Bioorg, Med. Chem. Lett., 2007, 17, 2229-2232.
Jordan K. Zjawiony, Wentao Jin, Leif Ryvarden, Scott G. Franzblau. "Antitubercular Activity of Metabolites of Higher Basidiomycetes", Int. J Med. Mushr., 2007, 9,220-221.
Ruslan V. Bikbulatov, Feng Yan, Bryan L. Roth, and Jordan K. Zjawiony. “Convenient Synthesis and in Vitro PharmacologicalActivity of 2-Thioanalogs of Salvinorin A and B”, Bioorg, Med. Chem. Lett., 2007, 17, 2229-2232.
Ruslan V. Bikbulatov, Jeremy Stewart, Wentao Jin, Feng Yan, Bryan L. Roth, Daneel Ferriera and Jordan K. Zjawiony. „Short Synthesis of a Novel Class of Salvinorin A Analogs with Hemiacetalic Structure”, Tetrahedron Lett., 2008, 49, 937-940.
R. Capasso, F. Borrelli, J. Zjawiony, L. Kutrzeba, G. Aviello, G. Sarnelli, F. Capasso, A.A. Izzo. “The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation-induced hypermotility in mice”. Neurogastroenterology and Motility, 2008, 20, 142-148.
Lukasz M. Kutrzeba, Franck E. Dayan, José-Luis Giner, Jordan K. Zjawiony, “13C and 2H Labeled Deoxyxylulose as a Tool in Study of Kinetics and Mechanism of Salvinorin A Biosynthesis”, abstract from 7th Annual Oxford International Conference on the Science of Botanicals & American Society of Pharmacognosy 4th Interim Meeting, University, MS, April 12-16, 2008, Planta Medica, 2008, 74, 331-332.
Lukasz M. Kutrzeba, Jordan K. Zjawiony, Franck E. Dayan, “Salvinorin B as a Putative
Biosynthetic Precursor of Salvinorin A. Study on O-acetyltransferase in Glandular
Trichomes Isolated from Salvia divinorium”, abstract from 7th Annual Oxford International
Conference on the Science of Botanicals & American Society of Pharmacognosy 4th Interim
Meeting, University, MS, April 12-16, 2008, Planta Medica, 2008, 74, 332.
Paulo Carvalho, Ruslan Bikbulatov, Jordan K. Zjawiony and Mitchell Avery. “Unusual Hemi-acetal Structure Derived from Salvinorin A”, Acta Cryst. E., 2008 E64, o1370-o1371.
Robert C. Tuckey, Wei Li, Jordan K. Zjawiony, Michal A. Zmijewski, Minh N. Nguyen, Trevor Sweatman, Duane Miller and Andrzej Slominski, “Pathways and Products for the Metabolism of Vitamin D3 by Cytochrome P450scc (CYP11A1)”, FEBS J., 2008 275, 2585-2596.
M. A. Zmijewski, W. Li, J. K. Zjawiony, T. W. Sweatman, J. Chen, D. D. Miller, A. T. Slominski, “Synthesis and Photoconversion of Androsta- and Pregan-5,7-dienes to Vitamin D3-like derivatives”, Photochem. Photobiol. Sci., 2008, 7, 1570-1576.
Robert. C. Tuckey, Zorica Janetovic, Wei Li, Minh N. Nguyen. Micjal A Zmijewski, Jordan Zjawiony and Andrzej Slominski, “Metabolism of 1a-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1a,20-dihydroxyvitamin D3”, J. Steroid Biochem. Mol. Biol., 2008, 112, 213-219.
R. Capasso, F. Borrelli, M. Cascio, G. Aviello, K. Huben, J. Zjawiony, P. Marini, B. Romano, V. DiMarzo, F. Capasso, A. Izzo. “Inhibitory effect of salvinorin A from Salvia divinorum on ileitis-induced hypermotility: cross-talk between κ-opioid and cannabinoid CB1 receptors”. Brit. J. Pharmacol. 2008, 155, 681-689.
M. A. Zmijewski, W. Li, J. K. Zjawiony, J. Chen, D. D. Miller, A. T. Slominski, “Photo-conversion of two epimers (20R and 20S) of pregna-5,7-diene-3ß,17a,20-triol and their bioactivity in melanoma cells”, Steroids 2009, 74, 218-228.
Andrzej T. Slominski, Michal A. Zmijewski, Igor Semak, Trevor Sweatman, Zorica Janjetovic, Wei Li, Jordan K. Zjawiony, Robert C. Tuckey, “Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin”, PLoS ONE, 2009, 4, e4309, 1-18.
Paulo Carvalho, Lukasz M. Kutrzeba, Jordan K. Zjawiony and Mitchell A. Avery. “(2S, 4aR, 6aR, 7R, 9S, 10aS, 10bR)-7-carboxy-2-(3-furyl)-6a,10b-dimethyl-4,10-dioxoperhydrobenzo[f]isochromen-9-yl acetate”, Acta Cryst. E., 2009 E65, o471-o472.
Jordan Zjawiony. “Antimicrobial and Antiviral Metabolites from Polypore Fungi” in “Novel Therapeutic Agents from Plants”, Eds. M.C. Carpinella and M. Rai, Science Publishers, Enfield, New Hampshire, USA, 2009, 36-59.
Dobroslawa Bialonska and Jordan K. Zjawiony. “Aplysinopsins –marine indole alkaloids: chemistry, bioactivity and ecological significance”. Marine Drugs, 2009, 7, 166-183.
Feng Yan, Ruslan V. Bikbulatov,V. Mocanu, Nedyalka Dicheva, Carol E. Parker, William C. Wetsel, Philip D. Mosier, Richard B. Westkaemper, John A. Allen, Jordan K. Zjawiony and Bryan L. Roth. “Structure-Based Design, Synthesis, and Biochemical and Pharmacological Characterization of Novel Salvinorin A Analogues as Active State Probes of the κ-Opioid Receptor”. Biochemistry, 2009, 48, 6898-6908.
Lukasz M. Kutrzeba, Daneel Ferreira, and Jordan K. Zjawiony. “Salvinorins J from Salvia divinorum: Mutarotation in the Neoclerodane System”, J. Nat. Prod., 2009, 72, 1361-1363.
J. Fichna, R. Schicho, A. Janecka, J. K. Zjawiony, M. Storr. “Selective natural KOR and CB1 agonists with potential role in gastrointestinal dysfunction”, Drug News & Perspectives, 2009 in press.
Lukasz M. Kutrzeba, Vardan T. Karamyan, Robert C. Speth, John S. Williamson and Jordan K. Zjawiony. “In vitro studies on metabolism of salvinorin A”, Pharm. Biol, 2009, in press.
Jakub Fichna, Rudolf Schicho, Christopher N. Andrews, Mohammad Bashashati, M. Klompus, Derek McKay, K.A. Sharkey, Jordan K. Zjawiony, Anna Janecka, Martin A. Storr. “Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating κ-opioid and cannabinoid receptors”, Neurogastroenterology and Motility, 2009, accepted.
Lukasz M. Kutrzeba, Daneel Ferreira, and Jordan K. Zjawiony. “Intramolecular transacetylation in salvinorins D and E”, J. Nat. Prod., 2009, submitted.
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