Nagle, D.G.; Zhou, Y.-D.  “Natural Products as Probes of Selected Targets in Tumor Cell Biology and Hypoxic Signaling”  Chapter 2.23 in Comprehensive Natural Products Chemistry II, Mander, L.N. ed. in chief; Vol. 2: Structural Diversity II – Secondary Metabolite Sources, Evolution, and Selected Molecular Structures, Moore, B.S., Crews, P., Vol. eds., Elsevier, Oxford, 2009, In Press

Nagle, D.G.; Zhou, Y.-D.  “Marine Natural Products as Inhibitors of Hypoxic Signaling in Tumors”  Phytochemistry Reviews, 2009, In Press.

Liu, Y.; Veena, C.K.; Morgan, J.B.; Mohammed, K.A.; Jekabsons, M.B.; Nagle, D.G.; Zhou, Y.-D.Methylalpinumisoflavone Inhibits Hypoxia-inducible Factor-1 (HIF-1) Activation by Simultaneously Targeting Multiple Pathways .”  Journal of Biological Chemistry, 2009, 284, 5859-5868.

Liu, Y.; Liu, R.; Mao, S.-C.; Morgan, J.B.; Jekabsons, M.B.; Zhou, Y.-D.; Nagle, D.G.  “Molecular-Targeted Antitumor Agents 19: Furospongolide from a Marine Lendenfeldia sp. Sponge Inhibits Hypoxia-Inducible Factor-1 (HIF-1) Activation in Breast Tumor Cells.”  Journal of Natural Products, 2008, 71, 1854-60.

El Sayed, K.A.; Shallal, H.M.; Khanfar, M.; Muralidharan, A; Awate, B.; Youssef, D.T.A.; Liu, Y.; Zhou, Y.-D.; Nagle, D.G.; Shah, G.  “Latrunculin A and its 17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells.”  Journal of Natural Products, 2008, 71, 1854-1860.

Chittiboyina, A.G.; Gundluru, M.K.; Carvalho, P.; Liu, Y.; Zhou, Y.-D.; Nagle, D.G.; Avery, M.A.  “Total Synthesis and Absolute Configuration of Laurenditerpenol: A HIF-1 Activation Inhibitor.”  Journal of Medicinal Chemistry, 2007, 50, 6299-6302.

Dai, J.; Liu, Y.; Zhou, Y.-D.; Nagle, D.G.  “Cytotoxic metabolites from an Indonesian sponge Lendenfeldia sp.”  Journal of Natural Products,2007, 70, 1824–1826.

Liu, R.; Liu, Y.; Zhou, Y.-D.; Nagle, D.G.  “Molecular-targeted antitumor agents 15: Neolamellarins from the marine sponge Dendrilla nigra inhibit hypoxia-inducible factor-1 (HIF-1) activation and secreted vascular endothelial growth factor (VEGF) production in breast tumor cells.”  Journal of Natural Products,2007, 70, 1741–1745.

Dai, J.; Liu, Y.; Jia, H.; Zhou, Y.-D.; Nagle, D.G.  “Benzochromenones from the marine crinoid Comantheria rotula inhibit hypoxia-inducible factor-1 (HIF-1) reporter activity and differentially suppress the growth of certain tumor cell lines.”  Journal of Natural Products,2007, 70, 1462-1466.

Dai, J.; Liu, Y.; Zhou, Y.-D.; Nagle, D.G.  “Hypoxia-selective antitumor Agents:  Norsesterterpene peroxides from the marine sponge Diacarnus levii preferentially suppress the growth of tumor cells under hypoxic conditions.”  Journal of Natural Products, 2007, 70, 130-133.

Dai, J.; Fishback, J.A.; Zhou, Y.-D.; Nagle, D.G.  “Sodwanone and yardenone triterpenes from a South African species of the marine sponge Axinella inhibit hypoxia-inducible factor-1 (HIF-1) Activation in both Breast and Prostate Tumor Cells.”  Journal of Natural Products,2006, 69, 1715-1720.

Nagle, D.G; Ferreira, D.; Zhou, Y.-D.  “Molecules of interest: Epigallocatechin-3-Gallate (EGCG): Chemical and biomedical perspectives.”  Phytochemistry, 2006, 67, 1849-1855.

Nagle, D.G.; Zhou, Y.-D.  “Natural product-derived small molecule activators of hypoxia-inducible factor-1 (HIF-1).”  Current Pharmaceutical Design, 2006, 12, 2673-2688.

Nagle, D.G.; Zhou, Y.-D.  “Natural product-based inhibitors of hypoxia-inducible factor-1 (HIF-1).”  Current Cancer Drug Targets, 2006, 7, 355-369.

Mora, F.D; Jones, D.K.; Desai, P.V.; Patny, A.; Avery, M.A.; Feller, D.R.; Smillie, T.; Zhou, Y.-D.; Nagle, D.G.  “Bioassay for the identification of natural product-based activators of peroxisome proliferator-activated receptor-g (PPARg): Themarine sponge metabolite psammaplin A activates PPARg and induces apoptosis in human breast tumor cells.”  Journal of Natural Products, 2006, 69, 547-552. 

Hossain, C.F.; Kim, Y.-P.; Baerson, S.R.; Zhang, L.; Bruick, R.K.; Mohammed, K.A.; Agarwal, A.K.; Nagle, D.G.; Zhou, Y.-D. “Saururus cernuus lignans - Potent small molecule inhibitors of hypoxia-inducible factor-1.”  Biochemical and Biophysical Research Communications, 2005, 333, 1026-1033.

Zhou, Y.-D.; Kim, Y.-P.; Mohammed, K.A.; Jones, D.K.; Muhammad, I.: Dunbar, D.C.; Nagle, D.G.  “The terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-Inducible factor-1 (HIF-1) in breast tumor cells.”  Journal of Natural Products,2005, 68, 947-950.

Zhou, Y.-D.; Kim, Y.-P.; Li, X.-C.; Baerson, S.R.; Agarwal, A.K.; Hodges, T.W.; Ferreira, D.; Nagle, D.G.  “Hypoxia-inducible factor-1 activation by (-)-epicatechin gallate: Potential adverse effects of cancer chemoprevention with high-dose green tea extracts.”  Journal of Natural Products, 2004, 67, 2063-2069.

Mohammed, K.A.; Hossain, C.F.; Zhang, L.; Bruick, R.K.; Zhou, Y.-D.; Nagle, D.G.  “Laurenditerpenol, a new diterpene from the tropical marine alga Laurencia intricata potently inhibits HIF-1 mediated hypoxic signaling in breast tumor cells.”  Journal of Natural Products, 2004, 67, 2002-2007.  (Jack L. Beal Award winning manuscript - American Society of Pharmacognosy)

Erbel-Sieler, C.; Dudley, C.; Zhou, Y.; Wu., X.; Estill, S.J.; Han, T.; Diaz-Arrastia, R.; Brunskill, E.W.; Potter, S.S.; McKnight, S.L.  “Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.”  Proceedings of the National Academy of Sciences USA, 2004, 101, 13648-13653.  (┴Equal contribution of authors)

Hodges, T.W.; Hossain, C.F.; Kim, Y.-P.; Zhou, Y.-D.; Nagle, D.G.  “Molecular-targeted antitumor agents: the Saururus cernuus dineolignans manassantin B and 4-O-demethylmanassantin B are potent inhibitors of hypoxia-activated HIF-1.”  Journal of Natural Products, 2004, 67, 767-771.

Nagle, D.G.; Zhou, Y.-D.; Mora, F.D.; Mohammed, K.A.; Kim, Y.-P.  “Mechanism targeted discovery of antitumor marine natural products.”  Current Medicinal Chemistry, 2004, 11, 1725-1756.