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Representative Publications

Barker, C., Fagan, J. B. and Pasco, D. S., Interleukin-1 beta Suppresses the Induction of P4501A1 and P4501A2 mRNAs in Isolated Hepatocytes, Journal of Biological Chemistry, 267, 8050-8055, (1992).

Pasco, D.S., Boyum, K.W., Elbi, C., Siu, C. Fagan, J.B., Inducer-Dependent Transcriptional Activation of the P4501A2 Gene In Vivo and in Isolated Hepatocytes, Journal of Biological Chemistry, 268, 1053-1057, (1993).

Robertson, R.W., Zhang, L., Pasco, D.S. and Fagan, J. B., Aryl Hydrocarbon-induced Interactions at Multiple DNA Elements of Diverse Sequence-A Multicomponent Mechanism for Activation of Cytochrome P4501A1 (CYP1A1) Gene Transcription, Nucleic Acids Research, 22, 1741-1749, (1994).

Reich, M., Robertson, R.W., Pasco, D.S. and Fagan, J. B., Down-regulation of Nuclear Aryl Hydrocarbon Receptor DNA-Binding and Transactivation Functions: Requirement for a Labile or Inducible Factor, Molecular and Cellular Biology, 14, 5653-5660, (1994).

Barker, C., Fagan, J. B. and Pasco, D.S., Down-Regulation of P4501A1 and P4501A2 mRNA Expression in Isolated Hepatocytes by Oxidative Stress, Journal of Biological Chemistry, 269, 3985-3990, (1994).

Robinson, C. E., Keshavarzian, A., Pasco, D.S., Frommel, T.O., Winship, D.H., and Holmes, E.W: Determination of Protien Carbonyl Groups by Immunoblotting. Analytical Biochemistry 266: 48-57, (1999).

Bedir, E., Pugh, N., Calis, I., Pasco, D.S., Khan, I.A.: Immunostimulatory effects of cycloartane-type triterpene glycosides from Astragalus species. Biological and PharmaceuticalBulletin 266:(2000).

Nagle G.D., Zhou, Y.D., Park, P.U., Paul, V.J., Rajbhandari, I., Duncan, C.J.D., and Pasco, D.S. A New Indanone from the Marine Cyanobacterium Lyngbya majuscula That Inhibits Hypoxia-Induced Activation of the VEGF Promoter in Hep3B Cells. Journal of Natural Products 63:1431-1433, (2000).

Pugh, N., Ross, S.A., ElSohly, M.A., and Pasco, D.S. Characterization of Aloeride, a New High Molecular Weight Polysaccharide from Aloe vera With Potent Immunostimulatory Activity. Journal of Agricultural and Food Chemistry 49: 1030-1034, (2001).

Pugh, N., Khan, I.A., Moraes, R. M., and Pasco, D.S. Podophyllotoxin Lignans Enhance IL-1beta But Suppress TNF-alfa mRNA Expression in LPS-Treated Monocytes. Immunopharmacology and Immunotoxicology 23: 83-95, (2001).

Subbaramaiah, K., Bulic, P., Lin, Y., Dannenberg, A.J., and Pasco, D.S. Development and Use of a Gene Promoter-Based Screen to Identify Novel Inhibitors of Cyclooxygenase-2 Transcription. Journal of Biomolecular Screening 6:101-110, (2001).

Pugh, N., Ross, S.A., ElSohly, H.N., ElSohly, M.A., and Pasco, D.S. Isolation of Three New Polysaccharide Preparations With Potent Immunostimulatory Activity From Spirulina platensis, Aphanizomenon flos-aquae and Chlorella pyrenoidosa. Planta Medica 67:737-742, (2001).

Zhang, Z., ElSholy, H.N., Jacob, M.R., Pasco, D.S., Walker, L.A., Clark, A.M. Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii. Planta Medica 68:49-54, (2002).

Pasco, D.S. Using Transcription Factor Based Assays to Study Herbal Products. In Drug Discovery and Traditional Chinese Medicine:Science, Regulation, and Globalization (Ed. Yuan Lin) pp. 81-87. Kluwer Academic Publishers. Boston/Dordrecht/London, (2001).

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