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Representative Publications

“The Role of Chemical Fingerprinting: Application to Ephedra”, B.T. Schaneberg, S. Crockett, E. Bedir and I. A. Khan, Phytochemistry, accepted.

“An improved HPLC Method for Quantitative Determination of Six Triterpenes in Centella asiatica Extracts and Commercial Products,” B.T. Schaneberg, J.R. Mikell, E. Bedir, and I.A. Khan, Die Pharmazie, accepted.

“Microbial transformation of phthalideisoquinoline alkaloid,(-)-B-hydrastine” Herath, W.H.M.W., Ferreier, D., Khan, I.A., Natural Product Letters, accepted.

“Microbial metabolites of Harman alkaloids.” Herath, W.H.M.W., Mikell, J.R., Ferreir, D., Khan, I.A., Phytochemistry, accepted.

“Microbial transformation of xanthohumol.” Herath, W.H.M.W., Ferreier, D., Khan, I.A., Phytochemistry, accepted.

“Evaporative Light Scattering Detection of Pyrrolizidine Alkaloids” B.T. Schaneberg, R.J. Molyneux and I.A. Khan, Phytochemical Analysis, accepted.

“Quantitative Analysis of Forskolin in Coleus forskohlii (Lamiaceae) by Reverse Phase High Performance Liquid Chromatography”, B.T. Schaneberg and I.A. Khan, Journal of AOAC International, accepted.

“Quantitative Analysis of Withanolides in Withania somnifera (Ashwagandha) by High Performance Liquid Chromatography,” M. Ganzera, M.I. Choudhary, I.A. Khan, Fitoterapia, accepted.

"Anxiolytic Properties of Piper methysticum extract samples and fractions in the Chick Social-Separation Stress Procedure,” M. Feltenstein, L.C. Lambdin, M. Ganzera, R. Dharmaratne, D. Nanayakkara, I.A. Khan, K.J. Sufka, Phytotherapy Research, accepted.

“HPLC Fingerprinting and Estimation of Bioactive Components of Clutia richardiana L. as a Potential Hypoglycemic Herbal Tea,” E.A. Abourashed, M. Ganzera, I.A. Khan, S. Khan, J.S. Mossa, F.S. El-Feraly, Phytotherapy Research, November (2001), accepted.

“High-Speed Extraction and HPLC Fingerprinting of Medicinal Plants- II. Application to Harman Alkaloids of Genus Passiflora,” Ehab. A. Abourashed, John Vanderplank, and I.A. Khan, Pharmaceutical Biology, accepted.

“Determination of Saponins and Alkaloids in Caulophyllum thalictroides (Blue Cohosh) by High Performance Liquid Chromatography and Evaporative Light Scattering Detection,” M. Ganzera, H.R.W. Dharmaratne, N.P.D. Nanayakkara, I.A. Khan, Phytochemical Analysis, accepted.

“Two new prosapogenins from Albizia adianthifolia,” Haddad, M., Khan, I., and Lacaille-Dubois , M.A., Die Pharmazie, 57 (10), 705-708, (2002), Jan 2002.

“In vitro Plant Regeneration from Leaf-derived Callus of Cimicifuga racemosa,” H.Lata, E. Bedir, A. Honsik, M. Ganzera, I.A. Khan, R.M. Moraes, Planta Medica, 68(10), 912-915, (2002).

“Determination of Aristolochic acid I and II in North American Species of Asarum and Aristolochia,” B. T. Schaneberg, W. L. Applequist and I.A. Khan, Die Pharmazie, 57 (10), 686-689, (2002).

“Anti-apoptotic Properties of Ginkgo biloba Extract EGb761 in Differentiated PC12 Cells” Smith, J., Burdick, A., Golik, P., Khan, I., Wallace, D., Luo, Y.. Cellular & Mol. Biology, 48(6), 699-707, (2002).

Ginkgo biloba Extract EGb761 Increases Stress Resistance and Extends Life Span of Caenorhabditis elegans” Wu, Z., Smith, J., Paramasivam, V., Butko, P., Khan, I., Cypser, J. R., Luo, Y. Cellular & Mol. Biology, 48(6), 725-731, (2002)

“Inhibition of Amyloid-? Aggregation and Caspase-3 Activation by the Ginkgo biloba Extract EGb761” Luo, Y., Smith, J., Paramasivam, V., Burdick, A., Curry, K. J., Buford, J. P., Khan, I., Netzer, W. J., Xu, H., Butko, P.. Proc. Natl. Acad. Sci. 99(19), 12197-12202, (2002).

"Determination of beta Adrenergic Receptor Blocking Pharmaceuticals in United States Water Effluent," D. B. Hugget, I. A. Khan, J. C. Allgood, C. M. Foran, D. Schlenk, Water Research, 121(2) 199-205, 2003.

“Fatty Acid Synthase inhibitors from Plants: Isolation, Structure Elucidation and SAR Studies”. Li, Xing-Cong; Joshi, Alpana S; El Sohly, Hala N.; Khan, Shabana I.; Jacob, Melissa R.; Zhang Zhizheng; Khan, Ikhlas A.;Ferreira, Daneel; Walker, Larry A., Broedel, Sheldon E, J.; Raulli, Robert E.; Cihlar, Ronald L. J. Nat. Prod., AN 2002:851257, CA.

"3?,4?-epoxyvalerenic acid from Valeriana officinalis,” H. Ranjith W. Dharmaratne, N. P. Dhammika Nanayakkara and Ikhlas A. Khan, Planta Medica, 68(7), p.661-662, (2002).

“Characterization of the Estrogenic Response to Genistein in Japanese medaka (Oryzias latipes),” L. Zhang, I. A. Khan and C. M. Foran , Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 132C(2), p. 203-211, (2002).

“Composition of the Essential Oil of Lepidium Maynii;” Tellez, Mario R., Khan Ikhlas A., Kobaisy, Mozaina, Ashrader, Kevin K., Dayan, Frank E. and Weste, Osbrink, Phytochemistry 61(2), p.149-155, (2002).

“The Inhibitory Activity of Natural Products on Plant p-Hydroxyphenylpyruvate Dioxygenase,” G. Meazza, B.E. Scheffler, M.R. Tellez, A.G. Rimando, J.G. Romagni, S.O. Duke, D. Nanayakkara, I.A. Khan, E.A. Abourashed, and Dayan, Phytochemistry, 60(3), p.281-288, (2002).

“Three new triterpene saponins from two species of Carpolobia,” Mitaine-Offer, A.C. Miyamoto, T., Khan, I., Delaude, C., and Lacaille-Dubois, M.A., J. Nat. Prod., 65(4), p.553-557, (2002).

"Biologically Active Steroidal Glycosides from Tribulus terresteris,” Erdal Bedir, Ikhlas A. Khan and Larry A. Walker, Biol. Pharm. Bull, 57 (7) p. 491-494, (2002).

“Chemical Profiling and Standardization of Lepidium meyenii (Maca) by Reversed Phase High Performance Liquid Chromatography,” M. Ganzera, J. Zhao, I. Muhammad, I.A. Khan, Chem Pharm Bull, 50(7) p.988-991 (2002)

“Biologically Active Secondary Metabolites from Ginkgo biloba,” Erdal Bedir, Irem I. Tatli, Riaz A. Khan, Jianping Zhao, Satashi Takamatsu, Larry A. Walker, Peter Goldman and Ikhlas A. Khan, J. Agri. Food Chem. 50 (11), pp.3150-3155, (2002).

"Evaluation of Podophyllum peltatum accessions for podophyllotoxin production,” Rita Moraes, Ebru Bedir, Holly Barret, Charls Burandt Jr., Camilo Canel and Ikhlas Khan, Planta medica, 68, 341-344, (2002)

"Constituents of Lepidium meyenii (Maca),” Ilias Muhammed, Jianping Zhao, D. Chuck Dunbar, Ikhlas A. Khan, Phytochemistry, 59(1), 105-110, (2002).

"Kavalactones from Piper methysticum and 13C-NMR Spectroscopic analyses,” H. Ranjith W. Dharmaratne, N. P. Dhammika Nanayakkara and Ikhlas A. Khan, Phytochemmistry, 59 (4), 429-433, (2002).

"The Ginkgolide Hydrates: Ginkgolide A, Ginkgolide C and Ginkgolide J," Zhao Jianping, Ilias Muhammad, D. Chuck Dunbar, Ikhlas A. Khan, Nikolaus H. Fischer and Frank R. Fronczek, Acta Crystallographia, 58(3), 195-198,(2002).

“Comparison of Extraction Methods for Marker Compounds in the Essential oil of Lemon Grass by GC,” Schaneberg, Brian T., Khan, Ikhlas Khan A. J. Agri. and Food Chemistry, 50 (6), 1345-1349, (2002).

"Hypericum perforatum- Chemical Profiling and Quantitative Results of St. John's Wort Products by an improved High Performance Liquid Chromatography Method," M. Ganzera, J. Zhao and I. A. Khan. J. Pharm. Sci, 91 (3), 6223-630, (2002).

“High-Speed Extraction and HPLC Fingerprinting of Medicinal Plants- I. Application to Passiflora Flavonoids,” Ehab. A. Abourashed, John Vanderplank, and I.A. Khan, Pharmaceutical Biology, 40(02), pp. 81-91, (2002).

"The Ethnomedicinal Use of Magnoliaceae from the Southeastern United States as Leads in Drug Discovery,” Wolfgang Schuhly, Ikhlas Khan and Nikolaus H. Fischer, Pharmaceutical Biology, 39, 63-69, (2001).

"GC Determination of Parthenolide in Feverfew Products," E. A. Abourashed and I. A. Khan, Die Pharmazie, 56(12), 971-972, (2001).

"Analysis of Sesquiterpenes in Valeriana officinalis by Capillary Electrophoresis,” J.R. Mikell, M. Ganzera, I. A. Khan, Die Pharmazie, 56(12), 946-948, (2001).

"Determination of Steroidal Saponins in Tribulus terrestris by Reversed-Phase High Performance Liquid Chromatography and Evaporative Light Scattering Detection,” M. Ganzera, E. Bedir, I. A. Khan, J. Pharm. Sci., 90, 1752-1758, (2001).

"A new lignan Glycoside from Eleutherococcus senticosus," Xing-Cong Li, Dayna L. Barnes and Ikhlas A Khan, Planta medica, 67, 776-778, (2001).

“A Reversed Phase High Performance Liquid Chromatography method for the Analysis of Boswellic Acids in Boswellia serrata," Markus Ganzera and Ikhlas A. Khan, Planta medica, 67, 778-780, (2001).

"Analysis of Sesquiterpene Lactones in Magnolia grandiflora L. by Micellar Electrokinetic Capillary Chromatography,” M. Ganzera, M. Mair, H. Stuppner, N. Fischer, I.A. Khan, Chromatographia, 54, 665-668, (2001).

"Determination of Nepetalactone in Nepeta cataria by Reversed Phase High Performance Liquid Chromatography,” M. Ganzera, S. Crockett, M. Tellez, I.A. Khan, Die Pharmazie, 56, 896-897, (2001).

"Drug Absorption In Vitro Model: Filter-Immobilized Artificial Membranes. 2a Studies of the permeability Properties of Lactones in Piper methysticum Forst," Alex Avdeef, Melissa Strafford, Eric Block, Michael P. Balogh, Walter Chambliss and Ikhlas Khan, Eur. J. Pharm. Sci, 14(2), 271-280, (2001).

"Analysis of Terpenelactones in Ginkgo biloba by High Performance Liquid Chromatography and Evaporative Light Scattering Detection,” M. Ganzera, J. Zhao, I.A. Khan, Chem. Pharm. Bull, 49(9), 1170-1173, (2001).

"Separation and Quantification of the Major Daucane Esters of Ferula hermonis by HPLC," Ehab Abourashed, Ahmad Galal, and Ikhlas Khan, Planta Medica, 67, 681-682, (2001).

"Trojanosides I-K: New cycloartane-type glycosides from the aerial part of Astragalus trojanus," Erdal Bedir, Irem I. Tatli, Ihsan Calis and Ikhlas A. Khan, Chem. Pharm Bull, 49 (11) 1482-1486, (2001).

"Antimalarial(+)-trans-Hexahydrodibenzopyran Derivative from Machaerium multiflorum," Ilias Muhammed, Xing-Cong Li, Chuck Bunbar, Mamoud A. Elsohly and Ikhlas A. Khan. J. Nat. Prod, 64(10),1322-1325, (2001).

"Improved HPLC Method for Determination of Betaine in Biological samples," Markus Ganzera, Pedro Pujol, Larry A. Walker, I. A. Khan. Die Pharmazie, 56(7), 552-553, (2001).

"HPLC Determination of Hydrastine and Berberine in Selected Goldenseal Products," E. A. Abourashed and I. A. Khan. J. Pharm. Sci., 90(7), 817-822, (2001).

"Improved Method for the Determination of Oxindole Alkaloids in Uncaria tomentosa by High Performance Liquid Chromatography,” M. Ganzera, I. Muhammad, R. A. Khan, I. A. Khan, Planta Medica, 67, 447-450, (2001).

"Separation of Astragalus Saponins by Reversed-Phase High Performance Liquid Chromatography and Evaporative Light Scattering Detection," M. Ganzera, E. Bedir, I. Calis, I. A. Khan, Chromatographia , 53 (3/4), 131-134, (2001).

"Anxiolytic effects of kava extract and kavalactones in the Chick Social Separation-Stress Paradigm," Kenyatta K. Smith, Ranjith Dharmaratne, Matt W. Feltenstein, Susan L. Broom, J. Todd Roach, Dhammika Nanayakkara, Ikhlas A. Khan and Kenneth J. Sufka. Psychopharmacology, 155(1), 86-90, (2001).

"The Stereoisomeric Pentacyclic Oxindole Alkaloids: Uncarine C and Uncarine E," Ilias Muhammad, Ikhlas A. Khan, Nikolaus H. Fischer, Frank R. Fronczek, Acta Crystallograhia, C57(4), 480-482, (2001).

"Investigation of Una De Dato.II. Anew Uncaria constituent and 15N NMR spectroscopic studies on Pentacyclic Oxindole Alkaloids," Illias Muhammad, D. Chuck Dunbar, Riaz A. Khan, Markus Ganzera and Ikhlas A. Khan, Phytochemistry, 57(5), 781-785, (2001).

"Analysis of Marker Compounds of Rhodiola rosea (Golden Root) by Rp-HPLC,” Markus Ganzera, Yurdanur Yayla and Ikhlas A. Khan, Chem Pharm. Bull., 49(4), 465-467, (2001).

"Two Novel Cycloartane-Type Triterpene Glycosides from the Roots of Astragalus prusianus," Erdal Bedir, Ihsan Calis, Chuck Dunbar, Rudraksh Sharan, John K. Buolamwini, Ikhlas A. Khan,Tetrahedron, 57, 5961-5966, (2001).

"A New Cyclolanostanol Arabinoside from the Rhizome of Cimicifuga racemosa," Erdal Bedir, and Ikhlas A. Khan, Die Pharmazie, 56, 268-269, (2001).

"Determination of Heavy Metals and Pesticides in Ginseng Products," Ikhlas A. Khan, James Allgood, Ehab A. Aborurashed, D. Schlenk, Larry A. Walker, and William H. Benson, J. Assoc. Off. Anal. Chem, 84(3), 936-939, (2001).

"High Yield of Podophyllotoxin from Leaves of Podophyllum peltatum by in-situ Conversion of Podophyllotoxin 4-O-beta-D-glucopyranoside,” C. Canel, F. Dayan, M. Ganzera, I. A. Khan, A. Rimando, C.L. Burandt, and R.M. Moraes, Planta Medica, 67, 1-3, (2001).

"Podophyllotoxin Lignans Enhance IL-1b but Suppress TNF-? mRNA Expression in LPS-Treated Monocytes," Nirmal Pugh, Ikhlas A. Khan, Rita M. Moraes and David S. Pasco, J. of Immunopharmacology and Immunotoxicology, 23 (1), 83-95, (2001).

"Organochlorine Pesticides and Metals in Select Botanical Dietary Supplements". D.B. Huggett, I. A. Khan, J. C. Allgood, D. S. Block, D. Schlenk. Bulletin of Environmental Contamination and Toxicology, 66, 150-155, (2001).

"A New Dammarane-Type Triterpene Glycoside From Polyscias fulva (Hiern) Harms," Erdal Bedir, Ngeh J. Toyang, Ikhlas A. Khan, Larry A. Walker, Alice M. Clark, J. Nat. Prod., NP0003589, (2001).

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