Representative Publications
(* denotes corresponding author)
Mayer, A.M.S.*, A.D. Rodriguez, R.G.S. Berlink and M.T. Hamann 2009. (in press) Marine pharmacology in 2005-2006: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action. Biochimica and Biophysica et Acta 1772.
Kevin II, D.A., D.A.F. Meujo and M.T. Hamann 2009. Polyether Ionophores: Broad-spectrum and Promising Biologically Active Molecules for the Control of Drug-resistant Bacteria and Parasites. Expert Opinion in Drug Discovery 4(2), 109-147.
El Sayed, K.A., A.A. Khalil, M. Yousaf, G. Labadie, G.M. Kumar, S.G. Franzblau, A.M.S. Mayer, M.A. Avery and M.T. Hamann* 2008. Semisynthetic Studies on the Manzamine Alkaloids. Journal of Natural Products 71, 300-308.
Bowling, J.J., H.K. Pennaka, K. Ivey, S. Wahyuono, M. Kelly, R.F. Schinazi, F.A. Valeriote, D.E. Graves and M.T. Hamann. 2008. Antiviral and anticancer optimization studies of the DNA-binding marine natural product aaptamine. Chemical Biology and Drug Design 71(3), 205-215.
Shilabin, A.G., N. Kasanah, B.L. Tekwani and M.T. Hamann* 2008. Kinetic studies and bioactivity of potential manzamine prodrugs. Journal of Natural Product. 71(7) 1218-1221.
Rao, K.V., M.K. Na, J.C. Cook, J. Peng, R. Matsumoto and M.T. Hamann. 2008. Kahalalides V–Y Isolated from a Hawaiian Collection of the Sacoglossan Mollusk Elysia rufescens. Journal of Natural Products, 71; 772-778.
Na, M., D.A.F. Meujo, D. Kevin, M.T. Hamann,* M. Anderson, R.T. Hill. 2008. A New Antimalarial Polyether from a Marine Streptomyces sp. H668. Tetrahedron Letters, 49 (44), 6282-6285.
Mohamed, N.M., K.V. Rao, M.T. Hamann, M. Kelly and R.T. Hill* 2008. Monitoring bacteria diversity of the marine sponge Ircinia strobilina on transfer to aquaculture. Applied and Environmental Microbiology 74 (13), 4133-4143.
Donia, M.S., B. Wang, D.C. Dunbar, P.V. Desai, A. Patny, M. Avery and M.T. Hamann* 2008. Mollamides B and C, cyclic hexapeptides from the Indonesian Tunicate Didemnum molle. Journal of Natural Products 71 (6), 941-945.
Tatli, I.I., X. Feng, G. Carter, K.V. Rao and M.T. Hamann* 2008. 7-Methyl-9-oxo-dec-7-eneoic acid from the Red Sea sponge Ircinia sp. Journal of Chemical Research, January, 50-51.
J.A. Diers, K.D. Ivey, A. El-Alfy, J. Shaikh, J. Wang, A.J Kochanowska, J.F. Stoker, M.T. Hamann and R.R. Matsumoto* 2008. Identification of antidepressant drug leads through the evaluation of marine natural products with neuropsychiatric pharmacophores. Pharmacology Biochemistry and Behavior 89, 46-53.
Kochanowska, A.J., K.V. Rao, S. Childress, A. El-Alfy, R.R. Matsumoto, M. Kelly, G.S. Stewart, K.J. Sufka and M.T. Hamann* 2008. Secondary metabolites from three Florida sponges with antidepressant activity. Journal of Natural Products 71, 186-189.
Ahmed, S.A., S.I. Khalifa and M.T. Hamann* 2008. Antiepileptic ceramides from the Red Sea sponge Negombata corticata. Journal of Natural Products 71 (4) 513-515.
Ibrahim, M.A., A.G. Shilabin, S. Prasanna, M. Jacob, S.I. Khan, R.J. Doerksen and M.T. Hamann* 2008. 2-N-Methyl Modifications and SAR Studies of Manzamine A. Bioorganic and Medicinal Chemistry 16, 6702-6706.
Fan, H., J. Peng, M.T. Hamann and J.F. Hu* 2008. Lamellarins and related pyrrole-derived alkaloids from marine organisms. Chemical Reviews 108, 264-287.
Bowling, J.J., A.J. Kochanowska, N. Kasanah and M.T. Hamann* 2007. Nature’s bounty-drug discovery from the sea. Expert Opinion in Drug Discovery 2(11), 1505-1522.
Ahmed, S.A., S. Odde, P.R. Daga, J.J. Bowling, M.K. Mesbah, D.T. Youssef, S.I. Khalifa, R.J. Doerksen and M.T. Hamann* 2007. Latrunculin with a highly oxidized Thiazolidone ring: structure assignment and actin docking. Organic Letters 9(23), 4773-4776.
Gul, W., N.L. Hammond, M. Yousaf, J. Peng, A. Holley and M.T. Hamann* 2007. Semisynthetic studies of the bioactive marine sesquiterpene (S)-(+)-curcuphenol isolated from a deep reef collection of several Jamaican sponges. Biochimica and Biophysica et Acta 1770, 1513-1519.
Choo, Y.M. and M.T. Hamann* 2007. An improved Pictet-Spengler Condensation: A convenient synthetic route to bioactive manzamine derivatives. Heterocycles 71 (2), 245-252.
Hua, H.M., J. Peng, D.C. Dunbar, R.F. Schinazi, A.G. de Castro Andrews, C. Cuevas, L.F. Garcia-Fernandez, M. Kelly and M.T. Hamann* 2007 Batzelladine alkaloids from the Caribbean sponge sponge Monanchora unguifera and the significant activities against HIV-1 AIDS opportunistic infectious pathogens. Tetrahedron 63, 11179-11188.
Hamann, M.T., D. Alonso, E. Martin-Aparacio, A. Fuertes, M. J. Perez-Puerto, A. Castro, S. Morales, M. L. Navarro, M. del Monte-Millán, M. Medina, H. Pennaka, A. Balaiah, J. Peng, J. Cook, S. Wahyuono, and A. Martinez* 2007. Glycogen Synthase Kinase-3 (GSK-3) Inhibitory Activity and Structure-Activity Relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease. Journal of Natural Products 70, 1397-1405.
Winkler, J.D.*, A.T. Londregan and M.T. Hamann* 2007. Synthetic modification of manzamine A via Grubbs metathesis. Novel structures with enhanced antibacterial and antiprotozoal properties. Organic Letters 9(22), 4467-4469,
Shilabin, A.G., N. Kasanah, D.E. Wedge and M.T. Hamann 2007. Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: Semisynthetic modifications and antifungal lead-exploration studies. Journal of Medicinal Chemistry 50, 4340-4350.
Mayer, A.M.S.*, A.D. Rodriguez, R.G.S. Berlink and M.T, Hamann 2007. Marine pharmacology in 2003-2004: Marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action. Comparative Biochemistry and Physiology, Part C 145. 61. 553-581.
Hamann, M.T., R. Hill and S. Roggo 2007. Marine Natural Products. Key advances to the practical application of this resource in drug development. Chimia 61(6). 313-321.
Hamann, M.T. 2007. The manzamines as an example of the unique structural classes available for the discovery and optimization of infectious disease controls based on marine natural products. Current Pharmaceutical Design 13. 653-660.
Gul, W., N.L. Hammond, M. Yousaf, J.J. Bowling, R.F. Schinazi, S.S. Wirtz, A.G. de Castro Andrews, C. Cuevas and M.T. Hamann* 2006 Modification at C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacteria, and tumor cell activity. Bioorganic and Medicinal Chemistry 14, 8495-8505.
Winkler, J.,* A. Londregan, J. Ragains, M.T. Hamann* 2006. Synthesis and Biological Evaluation of Manzamine Analogues. Organic Letters 8, 3407-3409.
Hamann, M.T. 2006. Book Review of: Methods in Biotechnology, Natural Products Isolation, Second Edition. Edited by Satyajit D. Sarker, Zahid Latif and Alexander Gray. Journal of Medicinal Chemistry 49, 2666.
Mohammed, R., J. Peng, M. Kelly and M.T. Hamann* 2006 New cyclic heptapeptides from the Jamaican sponge Stylissa caribica lennert & Van Sorest, 1998 (Halichondrida: Dictyonellidae) Journal of Natural Products. 69, 1729-1744.
Diers, J. A., J.J. Bowling, S.O. Duke, S. Wahyuono, M. Kelly and M.T. Hamann* 2006. Zebra Mussel Antifouling Activity of the Marine Natural Product Aaptamine and Analogs. Marine Biotechnology 8(4), 366-372.
Quinn, N.,* D. Gochfeld, M.T. Hamann, M. Slattery, L. Walker and B. Kojis 2006. Documenting and conserving biodiversity in Jamaican coral reefs while exploring for pharmacologically interesting natural products. Proceedings of the 10th International Coral Reef Symposium 800-809.
Rao, K.V., M.S. Donia, J. Peng, E. Garcia-Palomero, D. Alonso, A. Martinez, M. Medina, S.G. Franzblau, B.L. Tekwani, S.I. Khan, S. Wahyuono, K.L. Willett and M.T. Hamann* 2006. Manzamine B and E and Ircinal A Related Alkaloids from an Indonesian Acanthostrongylophora Sponge and Their Activity against Infectious, Tropical Parasitic, and Alzheimer's Diseases. Journal of Natural Products. 69, 1034-1040.
Khalifa, K.,* S. Ahmed, M. Mesbah, D. Yousaf and M.T. Hamann 2006. Quantitative determination of latrunculins A and B in the Red Sea sponge Negombata magnifica by high performance liquid chromatography. Journal of Chromatography B 832(1), 47-51.
Peng, J., N. Kasanah C.E. Stanley, J. Chadwick, F.R. Fronczek and M.T. Hamann* 2006. Microbial metabolism studies of cyanthiwigin B and synergetic antibiotic effects. Journal of Natural Products. 69(5), 727-730.
Bashyal, B., P. Desai, K.V. Rao, M.T. Hamann, B.A. Avery, J.K. Reed and M.A. Avery* 2006. Terpenes from Eunicea laciniata and Plexaurella nutans. Journal of Chemical Research. 8, 165-167.
Robert, F., Q.G. Hong, M. Donia, W.C. Merrick, M.T. Hamann and J. Pelletier* 2006. Chlorolissoclimides: New inhibitors of eukaryotic protein synthesis. RNA 12(5), 717-724.
Winkler, J.D.,* A.T. Londregan and M.T. Hamann* 2006. Antimalarial activity of a new family of analogues of manzamine A. Organic Letters 8 (12), 2591-2594.
Mohammed, R., J. Peng , M. Kelly, M.T. Hamann. 2006.
Cyclic Heptapeptides from the Jamaican Sponge Stylissa caribica.
Journal of Natural Products. 69(12):1739-1744. Link
Gul, W., N.L. Hammond , M.Yousaf, J.J. Bowling, R.F. Schinazi,
S.S. Wirtz , Andrews G. de Castro , C. Cuevas, M.T. Hamann. 2006.
Modification at the C9 position of the marine natural product isoaaptamine
and the impact on HIV-1, mycobacterial, and tumor cell activity. Bioorganic
& Medicinal Chemistry. 14(24):8495-505. Link
Rao KV, M.S. Donia , J. Peng, E. Garcia-Palomero, D. Alonso,
A. Martinez, M. Medina, S.G. Franzblau, B.L. Tekwani, S.I. Khan, S. Wahyuono,
K.L. Willett, M.T. Hamann. 2006. Manzamine B and E and ircinal
A related alkaloids from an Indonesian Acanthostrongylophora sponge and
their activity against infectious, tropical parasitic, and Alzheimer's diseases.
Journal of Natural Products. 69(7):1034-40. Link
Khalifa, K., S. Ahmed, M. Mesbah, D. Yousaf, M.T. Hamann.
2006. Quantitative determination of latrunculins A and
B in the Red Sea sponge Negombata magnifica by high performance
liquid chromatography. Journal of Chromatography B. 832:
47-51. Link
Winkler, J., A. Londregan, J. Ragains, M.T. Hamann.
2006. Synthesis and Biological Evaluation of Manzamine
Analogues. Organic Letters. Jul 20;8(15):3407-9. Link
Winkler, J., A. Londregan, M.T. Hamann. 2006.
Antimalarial activity of a new family of analogues of manzamine A.
Organic Letters. 8(12):2591-4. Link
Peng, J., N. Kasanah, C.E. Stanley, J. Chadwick, F.R. Fronczek,
M.T. Hamann. 2006. Microbial metabolism studies of cyanthiwigin
B and synergetic antibiotic effects. Journal of Natural Products. 69(5):727-30.
Link
Diers, J.A., J.J. Bowling, S.O. Duke, S. Wahyuono, M. Kelly,
M.T. Hamann. 2006. Zebra mussel antifouling activity of the marine
natural product aaptamine and analogs. Marine Biotechnology. 8(4):366-72.
Link
F. Robert, H.Q. Gao, M. Donia, W.C. Merrick, M.T. Hamann,
J. Pelletier. 2006. Chlorolissoclimides: new inhibitors of eukaryotic
protein synthesis. RNA. 12(5):717-25. Link
Kasanah, N. and M.T. Hamann. 2005. SPK-843
Aparts/Kaken. Current Opinion in Investigational Drugs. 6(8):
845-853. Link
Gul, W. and M.T. Hamann. 2005. Indole
alkaloid marine natural products: an established source of cancer drug leads
with considerable promise for the control of parasitic, neurological and other
diseases. Life Sciences. 78(5):442-53. Link
Hu, J.F., J. Peng and M.T. Hamann. 2005.
Bromopyrrole alkaloids from the Jamaican sponge Didiscus oxeata. Journal
of Chemical Research. 7, 427-428. Link
Bourel, L., K.V. Rao, M.T. Hamann and A. Ganesan. 2005.
Solid-phase total synthesis of kahalalide A and related analogues. Journal
of Medicinal Chemistry. 48(5), 1330-1335. Link
Mayer, A..S. and M.T. Hamann. 2005.
Marine Pharmacology in 2001-2002: compounds with anthelminthic, antibacterial,
anticoagulant, antidiabetic, antifungal, antiinflammatory, antimalarial, antiplatelet,
antiprotozoal, antituberculosis and antiviral activities; affecting the cardiovascular,
endocrine, immune and nervous systems and other miscellaneous mechanisms of
action. Comparative Biochemistry and Physiology, Part C Toxicology and Pharmacology.
140(3-4): 265-86. Link
Enticknap, J.J., R. Thompson, O. Peraud, J.E.
Lohr, M.T. Hamann and R.T. Hill. 2004. Molecular analysis
of a Florida Keys sponge: Implications for natural products discovery.
Marine Biotechnology 6, 288-293.
Pennaka, H.K., M. Yousaf, K.V. Rao, M. Kelly,
R.T. Hill, S.G. Franzblau, M.T. Hamann 2004. Solving
limited supplies of marine pharmaceuticals through the rational and high-throughput
modification of high-yielding marine natural product scaffolds. Marine
Biotechnology 6, S273-S280.
Kasanah, N., K.V. Rao, M. Yousaf, D.E. Wedge,
R.T. Hill and M.T. Hamann 2004. Biotransformation studies
of the manzamine alkaloids. Marine Biotechnology S268-S272.
Hua, H.H., J. Peng, F.R. Fronczek, M. Kelly
and M.T. Hamann 2004. Crystallographic and NMR studies
of anti-infective tricyclic guanidine alkaloids from the sponge Monanchora
unguifera. Bioorganic & Medicinal Chemistry 12, 6461-6464. Link
Diers, J.A., H.K. Pennaka, J. Peng, J.J. Bowling,
S.O. Duke, J.A. Schetz, and M.T. Hamann 2004. Structural
activity relationship studies of zebra mussel antifouling and antimicrobial
agents from Verongid sponges. Journal of Natural Products 67,
2117-2120. Link
Hamann, M.T. 2004. Technology
evaluation: Kahalalide F, PharmaMar. Current Opinion in Molecular Therapeutics
6(6) 657-665.
Kasanah, N. and M.T. Hamann 2004.
Development of antibiotics and the future of marine microorganisms to stem the
tide of antibiotic resistance. Current Opinion in Molecular Therapeutics
5(8), 827-837.
Rao, K.V., N. Kasanah, S. Wahyuono, B.L. Tekwani,
R.F. Schinazi and M.T. Hamann 2004. Three new manzamine
alkaloids from a common Indonesian sponge and their activity against infectious
and tropical parasitic diseases. Journal of Natural Products (Special
memorial edition for PJ. Scheuer and J. Faulkner) 67, 1314-1318. Link
Yousaf, M., N.L. Hammond, J. Peng, S. Wahyuono,
K.A. McIntosh, W.N. Charman, A.M.S. Mayer, and M.T. Hamann, 2004.
New Manzamine Alkaloids from an Indo-Pacific Sponge; Pharmacokinetics, Oral
Availability and the Significant Activity of Several Manzamines Against HIV-I,
AIDS Opportunistic Infections and Inflammatory Diseases. The Journal of
Medicinal Chemistry 47, 3512-3517. Link
Mayer, A.M.S. and M.T. Hamann 2004.
Marine Pharmacology in 2000: compounds with antibacterial, anticoagulant, antifungal,
anthelmintic, antiinflammatory, antiplatelet, antiprotozoal and antiviral activities;
affecting the cardiovascular, endocrine, immune and nervous systems and other
miscellaneous mechanisms of action. Marine Biotechnology 6, 37-52.
Peng, J., M. Avery and M.T. Hamann 2003.
Cyanthiwigin AC and AD, Two Novel Diterpene Skeletons from the Jamaican Sponge
Myrmekioderma styx. Organic Letters 5, 4575-4578. Link
Peng, J., J.F. Hu; A.B. Kazi, Z. Li, M. Avery,
O. Peraud, R. Hill, S.G. Franzblau, F. Zhang, R.F. Schinazi, S.S. Wirtz, P.
Tharnish, M. Kelly, S. Wahyuono and M.T. Hamann 2003.
Manadomanzamines A and B, a novel alkaloid ring system with potent activity
against Mycobacteria and HIV-1. Journal of the American Chemical Society
125, 13382-13386.
Donia, M., M.T. Hamann 2003.
Marine natural products and their potential applications as antiinfective agents.
The Lancet Infectious Diseases 3, 338-348.
Khalil, A.; El-Sayed, K.; Belal, F.; Khalil,
N. Y.; Hamann, M. 2003. Spectrofluorimetric determination of manzamine
A in spiked human urine and plasma. Pharmazie 58, 385-388.
Hamann, M.T. 2001. Book Review
of: Bioactive compounds from natural sources: isolation, characterization and
biological properties. Edited by Corrado Tringall. Journal of Natural Products.
64, 1382.
Rao, K.V., B.D. Santarsiero, A.D. Mesecar,
R.F. Schinazi, B.L. Tekwani and M.T. Hamann. 2003. New manzamine
alkaloids with significant activity against infectious and tropical parasitic
diseases from an Indonesia sponge. Journal of Natural Products. 66(6),
823-828.
Peng, J., J.F. Hu; A.B. Kazi, S.G. Franzblau,
F. Zhang, R.F. Schinazi, S.S. Wirtz, P. Tharnish, M. Kelly and M.T. Hamann.
2003. Manadomanzamines A and B, a novel antimycobacterial manzamine ring
system from an Indonesian sponge Petrosiidae sp. Journal of the American
Chemical Society. 125(44), 13382-13386.
Gochfeld, D.J., K.A. El Sayed P. Bartyzel,
X. Shen, S.P. Wilkins, J.K. Zjawiony, R.F. Schinazi, S. Schlueter-Wirtz P.M.
Tharnish and M.T. Hamann. 2003. Structurally diverse marine natural
products as anti-HIV agents. Mini Reviews in Medicinal Chemistry. 3(5),
401-424.
Takamatsu, S., T.W. Hodges, I. Rajbhandari,
W.H. Gerwick, M.T. Hamann and D.G. Nagle. 2003. Marine natural
products as novel antioxidant prototypes. Journal of Natural Products.
66(5), 605-608.
Duncan, C.J., F.R. Fronczek, M. Cuendet, J.M.
Pezzuto, R.G. Menta, M.T. Hamann and S.A Ross 2003.
Chemical and biological investigation of the fungus Pulveroboletus ravenelii.
The Journal of Natural Products. 66, 103-107.
Peng, J., X. Shen, K.A. El Sayed, D.C. Dunbar,
T.L. Perry, S.P. Wilkins M. Prinsen, S. Bobzin, J. Huesing, R. Camp, D, Krupa,
M.A. Wideman and M.T. Hamann 2003. Marine natural products
as agrochemical agents. The Journal of Agricultural and Food Chemistry.
51(8), 2246-2252.
Hamann, M.T. 2003. Enhancing
marine natural product structural diversity and bioactivity through semisynthesis
and biocatalysis. Current Pharmaceutical Design. 9, 879-889.
Orabi, K.Y., K.A. El Sayed, M.T. Hamann,
D.C. Dunbar, M.S. Al-Said, T. Higa and M. Kelly 2002. Araguspongines
K and L, new bioactive bis-1-oxaquinolizidine N-oxide alkaloids from Red Sea
specimens of Xestospongia exigua. The Journal of Natural Products.
65, 1782-1785.
Mayer, A.M.S. and M.T. Hamann 2002.
Marine Pharmacology in 1999: compounds with antibacterial, anticoagulant, antifungal,
anthelmintic, antiinflammatory, antiplatelet, antiprotozoal and antiviral activities;
affecting the cardiovascular, endocrine, immune and nervous systems and other
miscellaneous mechanisms of action. Comparative Biochemistry and Physiology,
Part C. 132, 315-339.
Kasanah, N., M. Yousaf; K.V. Rao; D. Wedge;
and M.T. Hamann. 2002. The biocatalytic conversion of
8-hydroxymanzamine A to manzamine A using Fusarium solani. Tetrahedron
letters. 44, 1291-1293.
Wilkins, S.P., A.J. Blum, T.J. Rutland, A.
Wierzbicki; M. Kelly and M.T. Hamann 2002. Isolation
of an antifreeze peptide from the Antarctic sponge Homaxinella balfourensis.
Cellular and Molecular Life Sciences. 59, 2210-2215.
El Sayed, K.A., M. Yousaf, M.T. Hamann,
M.A. Avery, M. Kelly and P. Wipf. 2002. Microbial and chemical
transformation studies of the bioactive marine sesquiterpene S-(+)-curcuphenol
and curcudiol isolated from the Deep Reef Collection of the Jamaican sponge
Didiscus oxeata. The Journal of Natural Products. 65, 1547-1553.
Hoye, T.R., S.E.N. Ayyad, B.M. Eklov, N.E.
Hashish, W. T. Shier, K.A. El Sayed and M.T. Hamann. 2002.
Toward computing natural product structures: 16-epi-latrunculin B, a new stereoisomer
of the potent actin polymerization inhibitor, latrunculin B. The Journal
of the American Chemical Society. 124, 7405-7410.
Peng, J., K., Walsh, V. Weedman, and M.T.
Hamann. 2002. The new bioactive diterpenes cyanthiwigin
E-AA from the Jamaican sponge Myrmekioderma styx. Tetrahedron.
58, 7809-7819.
Peng, J., S.G. Franzblau, F. Zhang and M.T.
Hamann. 2002. Novel sesquiterpenes and a lactone from the
Jamaican sponge Myrmekioderma styx. Tetrahedron Letters. 43,
9699-9702.
Hu, J.F., M. Kelly, M.T. Hamann . 2002.
26-Nor-25-isopropyl-ergosta-5,7,22E-trien-3a-ol,
a new C29 sterol from the Jamaican sponge Agelas sceptrum. Steroids.
67, 743-747.
Yousaf, M.; K.A. El Sayed, K.V. Rao, C.W. Lim,
J. Hu, M. Kelly, S.G. Franzblau, F. Zhang, O. Peraud, R.T. Hill and M.T.
Hamann, 2002. 12,34 Oxamanzamines, novel biocatalytic and
natural products from manzamine producing Indo-Pacific sponges. Tetrahedron.
58, 7397-7402.
El Sayed, K.A., K. Y. Orabi, D.C. Dunbar, M.T.
Hamann, M.A. Avery, Y.A. Sabnis, J.S. Mossa and F.S. El-Feraly 2002.
Transformation of lactone to lactam in sarcophine and antimalarial activity
of the resulting N-substituted azasarcophines. Tetrahedron. 58, 3699-3708.
Hu, J.F., J.A. Schetz, M. Kelly, J.N. Peng,
K.K.H. Ang, H. Flotow, C.Y. Leong, S.B. Ng, A.D. Buss, S.P. Wilkins, M.T.
Hamann . 2002 New antiinfective and human 5-HT2 receptor
binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia
aurea. Journal of Natural Products. 65, 476-480.
Hu, J.F., M. Kelly, H.F. Gao, M.T. Hamann
2001. Plakortides I-L, four new cyclic peroxides from an undescribed
Jamaican sponge Plakortis sp. (Homosclerophorida, Plakinidae).
Tetrahedron. 57, 9379-9383.
Perry, T.P., A. Dickerson, A.A. Khan, R.K.
Kondru, D.N. Beratan, P. Wipf, M. Kelly and M.T. Hamann 2001.
New peroxylactones from a Jamaican sponge Plakinastrella onkodes, with
inhibitory activity against the AIDS opportunistic parasitic infection Toxoplasma
gondii. Tetrahedron. 57, 1483-1487.
Gochfeld, D.J. and M.T. Hamann 2001.
The isolation and biological evaluation of filiformin, plakortide F and plakortone
G from the Caribbean sponge Plakortis sp. The Journal of Natural Products.
64, 1477-1479.
El Sayed, K.A., M.T. Hamann , N.E. Hashish,
T. Shier, and M. Kelly 2001. Antimalarial, antiviral and antitoxoplasmosis
norsesterterpene peroxide acids from a Red Sea sponge Diacarnus erythraeanus.
Journal of Natural Products. 64, 522-524.
El Sayed, K.A., M. Kelly, U.A.K. Kara, K.K.H.
Ang and M.T. Hamann 2001. New manzamine alkaloids with
potent activity against infectious disease. Journal of the American Chemical
Society. 123, 1804-1808.
Hu, J.F., Y. Hu, B. Zhao, X.Z. Feng and M.T.
Hamann 2001. New eudesmenoic acid methyl ester from Artemisia
selengensis. Spectroscopy Letters. 34(1). 75-81.
Dunbar, D.C., J.M. Rimoldi, A.M. Clark, M.
Kelly and M.T. Hamann 2000. Anti-cryptococcal and nitric
oxide synthase inhibitory imidazole alkaloids from the calcareous sponge Leucetta
cf chagosensis. Tetrahedron. 56, 8795-8798.
Chatterjee, P. S.A. Kouzi, J.M. Pezzuto and
M.T. Hamann 2000. Biotransformation of the antimelanoma
agent betulinic acid by Bacillus megaterium ATTC 13368. Applied
and Environmental Microbiology. 66, 3850-3855.
Ang, K.K.H., M.J. Holmes, T. Higa, M.T.
Hamann and U.A.K. Kara 2000. In vivo antimalarial activity
of the beta-carboline alkaloid manzamine A. Antimicrobial Agents and Chemotherapy.
44, 1645-1649.
El Sayed, K.A., P. Bartyzel, X. Shen, T.L.
Perry, J.K. Zjawiony, and M.T. Hamann 2000. Marine natural
products as antituberculosis agents. Tetrahedron. 56, 949-953.
Ross, S.A., J.D. Weete, R.F. Schinazi, S.S.
Wirtz, P. Tharnish, P.J. Scheuer and M.T. Hamann 2000.
Mololipids, a new series of anti-HIV bromotyramine-derived compounds from a
sponge of the order Verongida. Journal of Natural Products.
63, 501-503.
Cichewicz, R.H., S.A. Kouzi and M.T. Hamann
2000. Dimerization of resveratrol by the grapevine pathogen
Botrytis cinerea. Journal of Natural Products. 63, 29-3314.
Demirci, B., Baser, K.H.C., Demirci, F. and
M.T. Hamann 2000. New caryophyllene derivatives from
Betula litwinowii. Journal of Natural Products. 63, 902-904.
Kouzi, S.A., P. Chatterjee, J.M. Pezzuto and
M.T. Hamann 2000. Microbial transformation of the antimelanoma
agent betulinic acid. Journal of Natural Products. 63, 1653-1657.
Baser, K.H.C., Demirci, B., Demirci, F., Bedir,
E., Weyerstahl, P., Marschall, H., Duman, H., Aytac, Z., and M.T. Hamann
2000. A new bisabolene derivative from the essential oil of
Prangos uechtritzii fruits. Planta Medica. 66, 674-677.
El Sayed, K.A., A.M.S. Mayer, M. Kelly and
M.T. Hamann 1999. The biocatalytic transformation of
furan to amide in the bioactive marine natural product palinurin. Journal
of Organic Chemistry. 64, 9258-9260.
Shen, X., S.B. Krasnoff, S. Lu, D.C. Dunbar,
J. O'Neal, B.G. Turgeon, O.C. Yoder, D.M. Gibson and M.T. Hamann . 1999.
Characterization of 6-epi-3-anhydroophiobolin B from Cochliobolus heterostrophus.
Journal of Natural Products. 62, 895-897.
H. Gao, M. Kelly, M.T. Hamann 1999.
Bromotyrosine-derived metabolites from the sponge Aiolochroia crassa.
Tetrahedron. 55, 9717-9726.
Pennings, S.K. , V.J. Paul, D.C. Dunbar, M.T.
Hamann, W.A. Lumbang, B. Novack and R.S. Jacobs. 1999.
Unpalatable compounds in the marine gastropod Dolabella auricularia:
distribution and effect on diet. The Journal of Chemical Ecology. 25,
735-755.
Shen, X., T.L. Perry, D.C. Dunbar, M. Kelly-Borges
and M.T. Hamann . 1998. Debromosceptrin, an alkaloid
characterized using 15N NMR spectroscopy from the Caribbean sponge Agelas
sp. Journal of Natural Products. 61, 1302-1303.
J.K. Zjawiony , P. Bartyzel and M.T. Hamann.
1998. Chemistry of puupehenone: 1,6-conjugate addition to its
quinone-methide system. Journal of Natural Products. 61, 1502-1508.
El Sayed, K.A. , M.T. Hamann, H.A. Abd
El-Rahman and A.M Zaghloul. 1998. New pyrrole alkaloids from
Solanum sodomaeum. Journal of Natural Products. 61, 848-850.
El Sayed, K.A., M.T. Hamann , C.A. Waddling,
C. Jensen, S.K. Lee, C.A. Dunstan and J.M Pezzuto. 1998. Structurally
novel bioconversion products of the marine natural product sarcophine effectively
inhibit JB6 cell transformation. Journal of Organic Chemistry. 63,
7449-7455.
Bryan, P.J., J.B. McClintock and M.T. Hamann.
1997. Behavioral and chemical defenses of marine prosobranch
gastropod Calliostoma canaliculatum in response to sympatric seastars.
The Journal of Chemical Ecology. 23, 645-658
El Sayed, K.A., D.C. Dunbar, T.L. Perry, S.P.
Wilkins, M.T. Hamann , J.T. Greenplate and Margaret A. Wideman. 1997.
Marine natural products as prototype insecticidal agents. Journal of Agricultural
and Food Chemistry. 45, 2735-2739.
Ross, S.A., K.A. El Sayed , M.A. El Sohly,
M.T. Hamann, O.B. Abdel-Halim, A.F. Ahmed and M.M. Ahmed. 1997.
Phytochemical analysis of Geigeria alata and Francoeuria crispa essential oils.
Plant Medica. 63, 479-482.
Slattery, M , M.T. Hamann, J.B. McClintock,
T.L. Perry, M.P. Puglisi, W.Y. Yoshida. 1997. Ecological roles
for water-borne metabolites from Antarctic soft corals. Marine Ecology Progress
Series. 161, 133-144.
Reese, M.T., N.K. Gulavita, Y. Nakao, M.T.
Hamann, W.Y. Yoshida, S.J. Coval and P.J. Scheuer . 1996.
Kulolide: A Cytotoxic Depsipeptide from a Cephalaspidean mollusk, Philinopsis
speciosa. Journal of the American Chemical Society. 118, 11081-11084.
Hamann, M.T., C.S. Otto, P.J. Scheuer and D.C.
Dunbar 1996. Kahalalides, bioactive depsipeptides from the
sacoglossan mollusk Elysia rufescens and the green alga Bryopsis sp. Journal
of Organic Chemistry. 61, 6594-6600.
Wesson, K.J. and M.T. Hamann . 1996.
Keenamide A, a bioactive cyclic peptide from the marine mollusk Pleurobranchus
forskalii. Journal of Natural Products. 59, 629-631.
El Sayed, K.A. and M.T. Hamann . 1996.
A new norcembranoid dimer from the Red Sea soft coral Sinularia gardineri.
Journal of Natural Products. 59, 687-689.
El Sayed, K.A., D.C. Dunbar, D.K. Goins, C.R.
Cordova, T.L. Perry, K.J. Wesson and M.T. Hamann . 1996.
The marine environment: A resource for prototype antimalarial agents. Journal
of Natural Toxins. 5, 261-285.
Hamann, M.T., K.N. Harrison, A.R. Carroll and
P.J. Scheuer . 1996. Nui-inoalides, briarane diterpenes from
a Micronesian gorgonian. Heterocycles. 42, 325-331.
Nasu, S.S., B.K.S. Yeung, M. Kelly-Borges,
M.T. Hamann, P.J. Scheuer and D.K. Goins. 1995. Bioactive
sesquiterpenes from two Hawaiian sponges of the order Hyrtios. Journal
of Organic Chemistry. 60, 7290-7292.
Yeung, B.K.S., M. Kelly-Borges, M.T. Hamann
and P.J. Scheuer . 1994. Hapaioside: a pregnane glycoside from
the sponge Cribrochalina olemda. Tetrahedron. 50, 12593-12598.
McClintock, J.B. , B.J. Baker, M.T. Hamann,
W. Yoshida, M. Slattery, J. Heine, P.J. Bryan, G. Jayatilaka and B. Moon. 1994.
Homarine as a feeding deterrent in the common shallow-water Antarctic lamellarian
gastropod Marseniopsis mollis: a rare example of chemical defense in a marine
prosobranch. Journal of Chemical Ecology. 20, 2539-2549.
McClintock, J.B. , B.J. Baker, M.T. Hamann,
M. Slattery, R.W. Kopitzke and J. Heine. 1994. Chemotactic
tube foot Responses of the spongivorous sea star Perknaster fuscus
to organic extracts from Antarctic sponges. Journal of Chemical Ecology.
20, 859-870.
Baker, B. J. , R.W. Kopitzke, M.T. Hamann
and J.B. McClintock. 1993. Chemical ecology of Antarctic marine
invertebrates in McMurdo Sound, Antarctica: chemical aspects. Antarctic
Journal. U.S. 28, 132-133.
Hamann, M.T., P.J. Scheuer and M. Kelly-Borges.
1993. Biogenetically diverse, bioactive constituents of a sponge,
order Verongida: bromotyramines and sesquiterpene-shikimate derived
metabolites. Journal of Organic Chemistry 58, 6565-6569.
Hamann, M.T. and P.J. Scheuer . 1993.
Kahalalide F, a bioactive depsipeptide from the sacoglossan mollusk Elysia rufescens
and the green alga Bryopsis sp. Journal of the American Chemical
Society. 115, 5825-5826.
Hamann, M.T. 1992. Biologically
active constituents of some marine invertebrates. CA120(19): 240579K. Ph. D.
Dissertation.
Hamann, M.T. and P. J. Scheuer . 1991.
Cyanopuupehenol, an antiviral metabolite of a sponge of the order Verongida.
Tetrahedron Letters. 32, 5671-5672.
Book Chapters
Jin Feng Hu, Russell, Hill, Michelle Kelly and
Mark T. Hamann. 2003. The Marine b-carboline
Containing Alkaloids called the Manzamines in: “The Alkaloids: Biology and
Chemistry.” Volume 60, 205-283. CRC Press.
Nagle, D. G., G. N.Sultana, K. K. Schrader,
C. F. Hossain, R. Stanikunaite, M. T. Hamann, I. Rajbandari. 2003. Secondary
metabolites from plants and marine organisms as selective anti-cyanobacterial
agents in: American Chemical Society Symposium Series.
K.A. ElSayed, D.C. Dunbar, P. Bartzel, J.K.
Zjawiony, W. Day, and M.T. Hamann. 1999. Marine Natural Products as
Leads to Develop New Drugs and Insecticides in: "Biologically Active
Natural Products: Pharmaceuticals." CRC Press.
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Mark T. Hamann