The University of Mississippi - Department of Pharmaceutics

Curriculum Vitae

Michael A. Repka, B.S. Pharm., D.D.S., Ph.D.

PERSONAL INFORMATION:

Work Address:

The University of Mississippi
School of Pharmacy
Department of Pharmaceutics
University, MS 38677-1848
Ph: (662) 915-1155;
Fax: (662) 915-1177
marepka@olemiss.edu

Home Address:

810 Brentwood Cove
Oxford, MS 38655
Married to Staci L. Repka
Five Children

EXECUTIVE SUMMARY

Leadership and Management Experience:

• Founder & Chairman, Scientific Advisory Board of Oxford PolyMed Corporation • Founder, President and Chief Scientific Officer of Mikkur, Inc., Pharmaceutical R&D
• Founder of the Center for Thermal Pharmaceutical Processing (CTP2), Department of Pharmaceutics, School of Pharmacy, The University of Mississippi (Melt Extrusion and Pharmaceutical Excipient/Polymer Testing Center
• Founder and CEO of Repka & Associates, DDS, PC
• Write U.S. and foreign (PCT) patent applications
• Write Protocols for Institutional Review Boards (IRBs) at UM and UT Austin
• Wrote Protocols for Phase I, II and III clinical studies under FDA, IND #38,901
• Project Manager for Dental Product Development Company
• Consult with pharma on drug delivery, devices and product development
• Write Protocols for Institutional Animal Care and Use Committee (IACUC)
• Technology licensing & contract negotiations
• Member of Editorial Advisory Board for two scientific journals
• Write Business Plans
• Presentations to Angel funds, VCs, partners and collaborators
• Expert Witness and Patent Consultant
• Write regulatory documents (Clinical sections for IND and full 510k submissions)
• Served as Vice-President of Medical Center RPS, Inc.
• Write and implement technical research plans
• Initiation and coordination of numerous academic and industrial collaborations
• Served as Dental Staff Advisor of Regional Hospital
• Board of Directors, Atascosa National Bank
• Development/Implementation of Pharmacy Compounding course at UT & UM

Research and Development Experience:

• Advancement of Hot-Melt Extrusion Technology for pharmaceutical applications
• Founder of the Center for Thermal Pharmaceutical Processing (CTP2), Department of Pharmaceutics, School of Pharmacy, The University of Mississippi (Melt Extrusion and Pharmaceutical Excipient/Polymer Testing Center)
• Development and Patents for Bioadhesive Film Platforms for drug delivery systems
• Film drug delivery system via Hot-Melt Extrusion (HME) for oral candidiasis
• Alternative drug delivery systems for THC and pro-drugs
• Dental device product prototype via HME
• Formulation and Stabilization of novel semi-solid gel product for aphthous ulcers
• Novel nail drug delivery system for onychomycosis (fungal nail)
• Formulation & Stabilization of Hormone delivery system via HME for Phase I, II and III Clinical Trials
• Development of vaccine delivery systems via iHELP™ technology
• Concept/planning for Center for Thermal Pharmaceutical Processing (CTP2)
• Monitor Phase II Clinical study under auspices of FDA IND
• Principal Investigator for Phase I study for oral care product now in pre-Phase III
• Evaluation of dental materials for tooth restoration for major dental companies
• Topical and transmucosal delivery systems
• Solid, liquid, and semi-solid dosage forms: R&D, scale-up, and GMPs
• Pharmaceutics investigator in IGERT grant (UM and USM collaboration)
• 7 patents/patents pending

Research Highlights:

>60 Peer-reviewed publications in prestigious pharmaceutical journals
>170 Peer-reviewed abstract presentations
> 40 Invited Speaker presentations and workshops for major pharma, academia and global pharmaceutical/Excipient organizations
5 Appointments to External Advisory Boards of prestigious pharmaceutical journals
5 Patents/Patents Pending Out-licensed ($220K fee + >$1.0M milestones)
• Founder of the Center for Thermal Pharmaceutical Processing (CTP2)
• 2008 Researcher of the Year Award, presented by AAiPS for contributions to drug delivery via hot-melt extrusion technology, AAPS Annual Meeting, November 19, 2008, Atlanta, GA.
• Guest Editor Appointment for AAPS PharmSciTech, Running Theme Issue
• >$2.8 million awarded from grants and contracts, as PI or Co-PI, (NIH, Industry, other Federal Agencies)

EDUCATION

• University of Texas at Austin College of Pharmacy
Ph.D. in Pharmaceutics (August 2000—Completed Requirements, May 31, 2000)
Supervisor: Dr. James W. McGinity, Division Head of Pharmaceutics
Dissertation Title: "Physical-Mechanical and Chemical Properties of Topical Films Produced by Hot-Melt Extrusion"
• University of Texas Dental School at San Antonio (1977-1981)
Doctor of Dental Surgery 1981
Graduated with Highest Honors
• University of Texas at Austin College of Pharmacy (1973-1976)
B.S. in Pharmacy 1976
Graduated with Highest Honors
• University of Notre Dame (1972-1973) Dean's List

PROFESSIONAL EXPERIENCE

2012 - present

Director, Pii Center for Pharmaceutical Technology

2011—present

School of Pharmacy and Research Institute of Pharmaceutical Sciences (RIPS), The University of Mississippi, University, MS

Chair and Professor of Pharmaceutics and Research Professor of RIPS: Research programs focus primarily on the creation and investigation of novel delivery systems including films via hot-melt extrusion technology for transmucosal/transdermal delivery of drugs and mucosal vaccines. Research interests include "trans" systems, including oral transmucosal, transdermal and trans-nail drug delivery systems. Many of these systems are directed toward the delivery of poorly soluble drugs via Hot-Melt Extrusion techniques. Polymeric drug delivery design, including bioadhesive/biomaterial applications, stabilization of conventional and novel drug delivery systems for natural product compounds such as Tetrahydrocannabinol (THC and pro-drugs), in addition to antifungal/antibacterial agents and vaccines, is a continued focus of research. Director of the Center of Thermal Pharmaceutical Processing (CTP2)

2005—2011

School of Pharmacy and Research Institute of Pharmaceutical Sciences (RIPS), The University of Mississippi, University, MS

Chair and Associate Professor of Pharmaceutics and Research Associate Professor of RIPS:

2000—2005

School of Pharmacy and Research Institute of Pharmaceutical Sciences (RIPS), The University of Mississippi, University, MS Assistant Professor of Pharmaceutics and Research Assistant Professor of RIPS:

1989—present

Mikkur, Inc. (A MURA Company); Pharmaceutical Research and
Development Company, Oxford, MS (formerly located in Texas)

President and Chief Scientific Officer: Founded research and development company. Formulated and developed product for treatment of recurrent aphthous ulcers. Wrote and submitted parts of IND application. Managed project and obtained funding for research. Wrote Phase I, II and III protocols and currently in Phase III clinical trials. Many of these activities conducted while a graduate student at The University of Texas at Austin.

2004—present

Oxford PolyMed Corporation (A MURA Company); Pharmaceutical Development and Manufacturing Company, Oxford, MS

Founder & Chief Scientific Officer: Founded Oxford PolyScience in 2004, with a rename in 2008, as a spin-out from The University of Mississippi. Its objectives are to license, develop and manufacture technology from the University as well as other opportunities. The company is currently in its first round of funding to initiate development and manufacturing activities in the Oxford area. In addition, Oxford PolyMed has submitted a STTR application with UM to NIH/NIAID. My objective with the corporation is to be in an advisory capacity (CSO) to help select licensing opportunities (e.g. UM) for company development.

1995—2000

College of Pharmacy, The University of Texas at Austin, Austin, TX

Ph.D. Candidate: My experience included diverse training in material science and pharmaceutical processing including a variety of dosage forms. Experienced in design, optimization, manufacturing, stability testing and packaging of oral, semi-solid, liquid, transdermal, transmucosal and pMDI dosage forms utilizing calcitonin. Extensive knowledge in hot-melt extrusion, film coating, wet granulation, direct compression, extrusion/spheronization, USP test methods, DSC, GPC, HPLC, XRD, SEM and Instron. Supervised visiting scientists from chemical and pharmaceutical companies, post-docs, and other students. Wrote a protocol to conduct bioadhesion studies in vivo on human subjects, approved by The University of Texas IRB. Developed, implemented and coordinated novel pharmaceutical compounding program for undergraduate students at UT Austin.

1991—present

NewForm Development Laboratories, Inc, Georgetown, Texas

Project Manager (1993-1995) and Oral Care Consultant (1991-present): Responsible for formulation and development of new products including solid, semi-solid, and liquid dosage forms. Managed junior scientists and chemists. Interfaced with other research companies and distribution channels through travel in the U.S., Asia, and Europe. Utilized hot-melt extrusion technology for dental and medical applications, including scale-up. Involved in reformulating and troubleshooting two dental products currently marketed in the United States, Canada and Taiwan.

1993—1995

U.S. Medical Systems, Inc., Austin, Texas

Dental Project Manager:

Formulation and development of three new products including solid and liquid dosage forms. Headed troubleshooting efforts of two products licensed to Midwest Dental, Inc. Facilitated distribution channels through travel in the U.S. and Asia. Utilized hot-melt extrusion technology for development and scale-up of a medical device.

1981—1993

Repka & Associates, DDS, PC, Clinical Dentistry/Family Practice

President and CEO: Practiced general dentistry in a large dental practice that I founded in 1981. Managed yearly revenue of $1-2 million. Directed and supervised three dentists and over twenty other employees. Participated in numerous dental materials studies for several dental companies, including 3M and Dentsply. Wrote protocol and monitored Physician's IND clinical study on human subjects.

1985—1988

The University of Texas Dental School at San Antonio, San Antonio, TX

Assistant Clinical Professor: Practiced one day per week teaching dental students in the 'Simulated Private Practice' (SPP) Clinic. This entailed directing restorative dentistry and other dental procedures for student hands-on learning as well as teaching future dentists to work efficiently with other dental auxiliaries (dental assistants/dental hygienists). This 'four-handed' dental clinic was coordinated by Claude Padgett, D.D.S. Invited lecturer on material science, practice evaluation, and business. These experiences and activities have contributed to the enabling my teaching and research abilities at UM.

1988—1991

Baylor College of Dentistry, Dallas, TX

Assistant Adjunct Clinical Professor: Provided the opportunity to work with Baylor's Dental Preceptor and Residency Program. The program included working with a student for an eight-week rotation (40 hr/wk) in our dental clinic to provide real life dental practice experience. These fourth year dental students performed restorative and some surgical procedures under my guidance and direction. Also taught students practice management and the business aspects of dentistry. This experience also greatly enhanced my ability to serve in an academic setting, such as my recent position at UM.

1982—1993

Tri-City Regional Hospital of South Texas

Dental/Medical Staff Advisor: Awarded hospital privileges for dental surgical procedures. Worked closely with Chief of Anesthesiology, Dr. Adrian Polit. Advised medical staff concerning dental procedures and evaluated applications for potential new medical and dental staff members

1977—1981

Center Pharmacy and Zimmerman's Pharmacy, San Antonio, TX

1976—1977

Beeville Community Hospital, Beeville, TX

Pharmacist/Hospital Staff Pharmacist: Practiced pharmacy in both the retail and hospital setting while seeking my Doctor of Dental Surgery Degree.

HONORS AND AWARDS

• Vice-Chair, FDD Section of AAPS, 2011-2012 (Recently elected)
• Chair, Modified Release Focus Group of AAPS, 2010-2011
• Chair-Elect, Modified Release Focus Group of AAPS, 2009-2010
• Chair, Southern Regional Discussion Group of AAPS, 2009-2010
• 2008 Researcher of the Year Award, presented by AAiPS for contributions to drug delivery via hot-melt extrusion technology, AAPS Annual Meeting, November 19, 2008, Atlanta, GA.
• Received New Investigator Award, National IDeA Symposium of Biomedical Research Excellence, August 2008, Washington, DC
• Awarded First Prize for Oral Presentation, J. Morita Investigator Award for Geriatric Oral Research, 83rd General Session and Exhibition of the International Association of Dental Research (IADR), March 9-12, 2005, Baltimore, MD
• Delegate to the United States Pharmacopoeia Convention, March 2005, Washington, DC
• Southern Regional Discussion Group (SRDG) of AAPS—President-2005
• Elected to the United States Pharmacopoeia Committee—(2005-2010)
• Faculty Research Fellow 2003, The University of Mississippi
• American Association of Colleges of Pharmacy, New Investigator Program Grant
• American Foundation for Pharmaceutical Education Pre-doctoral Fellowship
• Alumnus of the Year—1992 University of Texas Dental School at San Antonio
• Medical/Dental Staff Advisor Tri-City Regional Hospital (1982-1989)
• Omicron Kappa Upsilon (Dental Honorary Society), 1981-Present
• Rho Chi (Pharmacy Honorary Society), 1976-Present
• Medical Center RPS, Inc. Vice-President (1987-1994)
• Atascosa National Bank Board of Directors (1988-1993)
• University of Texas Dental School at San Antonio Class President (1978-1980) Student Body President (1980-1981)

PROFESSIONAL AFFILIATIONS

• American Association of Pharmaceutical Scientists (AAPS)
• USP—Delegate: 2005-2015
• American Association of Colleges of Pharmacy (AACP)
• Manufacturing Science and Engineering Section (MSE Section) of AAPS Steering Committee (2009-present)
• Controlled Release Society (CRS)
• American Association of Dental Research (AADR)
• Rho Chi (Pharmacy Honorary Society)
• Omicron Kappa Upsilon (Dental Honorary Society)
• Drug Information Association (DIA)
• University of Texas College of Pharmacy Alumni Association, Life Member
• UT Dental School at San Antonio Alumni Assoc., Life Member
• Generations Club, University of Texas College of Pharmacy
• Sorin Society, University of Notre Dame (1987-1993)

CONSULTING ACTIVITY

Undisclosed Chemical Company, Tarrytown, NY (2009-present)
Three Undisclosed Pharma Chemical/Excipient Companies (2004-present)
Undisclosed Law Firm, Boston, MA (2007-present)
Undisclosed Pharma, Mississippi (2008—present)
Undisclosed Pharma, Ohio (2004—present)
Undisclosed Development/Manufacturing Laboratory, Texas (2001—present)
Undisclosed Law Firm, Washington, D.C. (2003, 2007)
Schering-Plough, Memphis, TN (2000-2002)

EDITORIAL ADVISORY BOARDS AND EDITORIAL ACTIVITIES
EAB:
2000 – present Drug Development and Industrial Pharmacy
2007 – present AAPS PharmSciTech
2007 – present Pharmaceutical Development and Technology
2009 – present Current Drug Delivery
2010 – present Expert Opinion on Drug Delivery

GUEST EDITOR: Running Theme Issue, AAPS PharmSciTech, "Advanced Technology for Controlled Drug Delivery", sponsored by the Modified Release Focus Group of AAPS, July 2009—June 2012.

REFEREE FOR SCIENTIFIC JOURNALS

• European Journal of Pharmaceutics and Biopharmaceutics
• Journal of Controlled Release
• Pharmaceutical Research
• Molecular Pharmaceutics
• AAPS PharmSciTech
• Journal of Dental Research
• International Journal of Pharmaceutics
• European Journal of Pharmaceutics
• Journal of Pharmacy and Pharmacology
• American Journal of Pharmaceutical Education
• Journal of Pharmaceutical Sciences
• Drug Development and Industrial Pharmacy
• Pharmaceutical Development and Technology
• Expert Opinion on Biological Therapy, Ashley Publications, London, UK
• Current Drug Delivery
• Drug Delivery Technology

PUBLICATIONS

Peer-Reviewed Publications

Vaka, S.K., Murthy, S.N., Anna Balaji, A. and Repka, M.A., Delivery of Brain Derived Neurotrophic Factor via Nose to Brain Pathway. Pharm. Res. (2011, in press).
Deng, W., Singh, A., Shah, S.P., Jo, S., Majumdar, S., Pinto, E., Tewari, D., Durig, T., Repka M.A., Solubility and stability enhancement of fenofibrate by low molecular weight hydroxypropylcellulose matrices produced by hot melt extrusion. Journal of Pharmaceutical Sci. [under review].
Palem CR, Battu SK, Gannu R, Yamsani VV, Repka MA, Yamsani MR., Role of cyclodextrin complexation in felodipine-sustained release matrix tablets intended for oral transmucosal delivery: In vitro and ex vivo characterization. Pharm Dev Technol. 2011 Jan 26. [Epub ahead of print]
Sammeta, SM, Repka, MA, Murthy, SN, Magnetophoresis in Combination with Chemical Enhancers for Transdermal Drug, Drug Dev. Ind. Pharm. in press (2011).
Garripelli, V.K., Kim, J.K., Son, S., Kim, W.J., Repka, M.A., Jo, S., Matrix metalloproteinase-sensitive thermogelling polymer for bioresponsive local drug delivery, Acta Biomater. In press, (IF:3.975)(2011).
Upadhye S.B., Kulkarni S.J., Majumdar S., Avery M.A., Gul W., ElSohly M.A., Repka M.A., Preparation and Characterization of Inclusion Complexes of a Hemisuccinate Ester Prodrug of Delta(9)-Tetrahydrocannabinol with Modified Beta-Cyclodextrins, AAPS PharmSciTech. (2010) (Invited Theme Edition) Jun;11(2):509-172.
Jin-Ki Kim, Vivek Kumar Garripelli, Ui-Hyeon Jeong, Jeong-Sook Park, M. A. Repka, Seongbong Jo, Novel pH-sensitive polyacetal-based block copolymers for controlled drug delivery, Int J Pharm, 401(1-2), 79-86, 2010.
Meiwan Chen, Xin Pan, Hongmei Wu, Ke Han, Xiaobao Xie, David E. Wedge, Michael A. Repka, Chuanbin Wu, Preparation and Anti-bacterial Properties of a Temperature-sensitive Gel containing Silver Nanoparticles, Pharmazie (2010), in press.
Charoo, N.A, Rahman, Z, Repka, M.A.,Murthy, S.N. Electroporation: An Avenue for Transdermal Drug Delivery, Curr Drug Deliv., Curr Drug Deliv., 2010 Apr;7(2):125-365.
Garripelli, V.K., Jim, J.-K., Namgung, R., Kim, W.J., Repka, M.A. and Jo, S., A novel thermosensitive polymer with pH-dependent degradation for drug delivery,Acta Biomaterialia, Feb. 6(2): 477-485 (2010).
S.R.K. Vaka, S.N. Murthy, J.H. O'Haver, M.A. Repka, A Platform for Predicting and Enhancing Model Drug Delivery across the Human Nail Plate, Drug Dev. Ind. Pharm. in press (2010).
S.K. Battu, S. Majumdar, S. Maddineni, A.G. Chittiboyina, M.A. Avery, M.A. Repka, Physicochemical Characterization of Berberine Chloride: A Perspective in the Development of a Solution Dosage form for Oral Delivery, AAPS PharmSciTech, in press (2010).
J.K. Kim, J. Anderson, H.W Jun, M.A. Repka, S. Jo, Self-assembling peptide amphiphile-based nanofiber gel for bioresponsive cisplatin delivery. Mol. Pharm. May-Jun;6(3):978-85 (2009).
S.Q. Zhang, Z. Rahman, S. Thumma, M.A. Repka, G. Chen, S. Li, Development and evaluation of a pH-dependent sustained release tablet for irritable bowel syndrome.Drug Dev. Ind. Pharm. 35(1), 57–64 (2009).
S. Thumma, and M.A. Repka, Compatibility studies of promethazine hydrochloride with tablet excipients utilizing thermal and non-thermal methods.Pharmazie. 2009 Mar;64(3):183-9.
M. A. Repka, Hot-Melt Extrusion, American Pharmaceutical Review, 12(6); 18-27, September/October (2009).
S. P. Boddu, M. R. Yamsani, S.Potharaju. S. Veeraraghavan, S. Rajak, S. Kumar, B.A. Avery, M.A. Repka, V.S. Kanthi Kiran Varanasi, Influence of grapefruit juice on the pharmacokinetics of diltiazem in wistar rats upon single and multiple dosage regimens,Pharmazie, 2009 Aug;64(8):525-31.
M.A. Repka, S. Majumdar, S.K Battu, R. Srirangam, S. Upadhye, Applications of hot-melt extrusion for drug delivery.Expert Opin. Drug Deliv. 5(12), 1357-1376 (2008).
Rahman, Z., Kohli, K. Zhang, S.Q., Khar, R.K., Ali, M., Charoo, N.A., Tauseef, M. Shamsher, A.A., Mohammed, N.N., Repka, M.A., In-vivo evaluation in rats of colon-specific microspheres containing 5-fluorouracil. J Pharm Pharmacol. (2008) 60(5): 615-623.
S. Majumdar, T. Hingorani, R. Srirangam, R.S. Gadepalli, J.M. Rimoldi, M.A. Repka,Transcorneal permeation of L - and D - aspartate ester prodrugs of acyclovir: delineation of passive diffusion versus transporter involvement. Pharm. Res. 2009 May;26(5):1261-9. Epub 2008 Oct 7.
S. Majumdar, K. Hippalgaonkar, M.A. Repka, Effect of chitosan, benzalkonium chloride and ethylenediaminetetraacetic acid on permeation of acyclovir across isolated rabbit cornea. Int. J. Pharm. 348(1-2), 175–178 (2008).
Tumuluri, V.S., Kemper, M.S., Lewis, I.R., Prodduturi, S. Majumdar, S., Avery, B.A., Repka, M.A., Off-line and on-line measurements of drug-loaded hot-melt extruded films using Raman spectroscopy. Int J Pharm, (2008), 357(1-2): 77-84 (PMID: 18316165)
Thumma, S., ElSohly, M.A., Zhang, Shuang-Qing, Gul, W., Repka, M.A., Influence of plasticizers on the stability and release of a prodrug of ∆9-tetrahydrocannabinol incorporated in poly (ethylene oxide) matrices, Eur J Pharm Biopharm, (2008), (DOI:10.1016/j.ejpb.2008.06.009).
Thumma, S., S. Majumdar, M. A. ElSohly, W. Gul and M. A. Repka. Chemical Stability and Bioadhesive Properties of an Ester Prodrug of Delta-9-Tetrahydrocannabinol in Poly (Ethylene Oxide) Matrices: Effect of Formulation Additives, Int. J. Pharm. 362 (2008), 126-132 (DOI: 10.1016/j.ijpharm.2008.06.025).
Thumma, S., S. Majumdar, M. A. ElSohly, W. Gul and M. A. Repka. Preformulation Studies of a Prodrug of Delta-9-Tetrahydrocannabinol, AAPS PharmSci Tech (2008), (DOI: 10.1208/s12249-008-9136-7)
26. Zhang, S.Q., Thumma, S., Chen, G.H., Deng, W.B., Repka, M.A., Li, S.M., In vitro and in vivo evaluation of tegaserod maleate pH-dependent tablets. Eur J Pharm Biopharm, (2008), 69(1); 247-254.
Thumma, S.Q. Zhang and M. A. Repka. Development and Validation of a High-Performance Liquid Chromatographic Method for the Analysis of Promethazine Hydrochloride in Hot-Melt Extruded Dosage Forms, Pharmazie, 63 (8), 2008, 562-567.
Majumdar, S. Hippalgaonkar, K., Repka, M.A., Effect of chitosan, benzalkonium chloride and ethylenediaminetetraacetic acid on permeation of acyclovir across isolated rabbit cornea. Int J Pharm, (2008), 348(1-2): 175-178.
Zhang, S.Q., Chen, G.H., Rahman, Z., Thumma, S., Li, S.M., Repka, M.A., Development and evaluation of a pH-dependent sustained release tablet for irritable bowel syndrome, Drug Development and Industrial Pharmacy (2008), 35(1), January 2009, pages 57-64.
Repka, M.A., Crowley, M.M., Battu, S.K., Upadhye, S.B., Thumma, S., Zhang, F., Martin, C., McGinity, J. Pharmaceutical Applications of Hot-Melt Extrusion: Part II. Drug Development and Industrial Pharmacy (2007), 33(10), 1052-1066.
Crowley, M.M., Repka, M.A., Thumma, S., Upadhye, S.B., Battu, S.K., Zhang, F., Martin, C., McGinity, J. Pharmaceutical Applications of Hot-Melt Extrusion: Part I. Drug Development and Industrial Pharmacy (2007), 33(9), 909-926.
Battu, S.K., Repka, M.A., S. Majumdar, M. Rao, Formulation and Evaluation of Rapidly Disintegrating Fenoverine Tablets: Effect of Superdisintegrants, Drug Development and Industrial Pharmacy (2007), 33(11), 1225-1232.
Mididoddi, P.K. and Repka, M.A., Characterization of hot-melt extruded drug delivery systems for onychomycosis, Eur. J. Pharm. Biopharm., 66(1), 95-105, (2007).
Trey, S. M.,Wicks, D. A., Mididoddi, P. K., Repka, M. A. Delivery of Itraconazole from Extruded hydroxypropylcellulose Films.Drug Development and Industrial Pharmacy (2007), 33(7), 727-735.
Prodduturi S, Urman K. L., Otaigbe J. U., Repka M. A. Stabilization of hot-melt extrusion formulations containing solid solutions using polymer blends. AAPS PharmSciTech. (2007), 29; 8(2): Article 50.
Moore, Q. C. III, Johnson, L., Repka, M. A. and McDaniel, L. S., Immunization with PspA Incorporated into a Poly(Ethylene Oxide) Matrix Elicits Protective Immunity against Streptococcus pneumoniae, Clinical and Vaccine Immunology, (2007), 14(6), 789-791.
Munjal, M., ElSohly, M.A., and Repka, M.A., Chemical Stabilization of a Δ9-Tetrahydrocannabinol Pro-Drug in Polymeric Matrix Systems Produced by a Hot-Melt Method: Role of Microenvironment pH, AAPS PharmSciTech, 7 (3), Article 71, (2006).
M.A. Repka, M. Munjal, M.A. ElSohly and S. Ross, Temperature stability and Bioadhesive properties of 9-Tetrahydrocannabinol incorporated Hydroxypropyl cellulose Polymer Matrix Systems, Drug Devel. Ind. Pharm, 32(1), 21-32, (2006).
Munjal, M., Stodghill, S., ElSohly, M.A., and Repka, M.A., Polymeric Systems for Amorphous D9-Tetrahydrocannabinol Produced by a Hot-Melt Method. Part I: Chemical and Thermal Stability during Processing, J Pharm Sci, 95(8), 1841-1853 (2006).
Munjal, M., ElSohly, M.A., and Repka, M.A., Polymeric Systems for Amorphous D9-Tetrahydrocannabinol Produced by a Hot-Melt Method. Part II: Effect of Oxidation Mechanisms and Chemical Interactions on Stability, J Pharm Sci, 95(11), 2473-2485 (2006).
Mididoddi, P.K., Prodduturi, S. and Repka, M.A., Influence of Tartaric Acid on the Bioadhesion and Mechanical Properties of Hot-Melt Extruded Hydroxypropyl Cellulose Films for the Human Nail, Drug Dev Ind Pharm, 32(9), 1059-1066, (2006).
S. Prodduturi, R.V. Manek, W.M. Kolling, S.P. Stodghill, M.A. Repka, Solid-State Stability and Characterization of Hot-Melt Extruded Poly(ethylene) Oxide Films, J. Pharm. Sci., 94(10), 2232-2245, (2005).
M. A. Repka, K. Gutta, S. Prodduturi, M. Munjal, S.P. Stodghill, Characterization of Cellulosic Hot-Melt Extruded Films containing Lidocaine, Eur. J. Pharm. Biopharm., 59(1), 189-95, 2005.
M. A. Repka and A. Singh, Alginic Acid, Handbook of Pharmaceutical Excipients, 6th Edition, American Pharmaceutical Association, November, (2009).
M.A. Repka, M. Munjal, S. Prodduturi and P. Mididoddi, Matrix and Reservoir-Based Oral Transmucosal Systems: Tailoring Delivery Solutions. American J. Drug Delivery, 2(3), 173-192, 2004.
M. A. Repka, P. Mididoddi, S. P. Stodghill, Influence of 'Etching' on Human Nails for the Assessment of Treatment Modalities for Onychomycosis, Int. J. Pharm., 283(1-2), 2004.
S. Prodduturi, R.V Manek, B. Kolling, S. P. Stodghill, M.A Repka. Water vapor sorption isotherms of hot-melt extruded hydroxypropyl cellulose films: Effect on physico-mechanical properties, release characteristics and stability, J. Pharm. Sci., 93(12), 3047-3056, 2004.
S. Tumuluri, S. Prodduturi, M. M. Crowley, S. P. Stodghill, J. W. McGinity, B. A. Avery and M. A. Repka, The use of Near-Infrared Spectroscopy for the Quantitation of a Drug in Hot-Melt Extruded Films, Drug Devel. Ind. Pharm., 30(5), 505-511, 2004.
M. M. Crowley, A. Fredersdorf, B. Schroeder, S. Prodduturi, M. A. Repka and J. W. McGinity, The Influence of Guaifenesin and Ketoprofen on the Properties of Hot-Melt Extruded Polyethylene Oxide Films, Eur J Pharm Sci, 22, 409-418, 2004.
J. W. McGinity and M. A. Repka, Hot-Melt Extruded Films for Transmucosal and Transdermal Drug Delivery Applications, Drug Del Tech, 4(7), 72-78, 2004.
M. A. Repka, S. Prodduturi and S. P. Stodghill, Production and Characterization of Hot-Melt Extruded Films containing Clotrimazole. Drug Devel. Ind. Pharm. 29(7), 2003.
M. A. Repka, J. O'Haver, C-H See, K. Gutta and M. Munjal, Nail morphology studies as assessments for onychomycosis treatment modalities. Int. J. Pharm., 245(1-2), 25-36 (2002).
M. A. Repka and J.W. McGinity,Bioadhesive Properties of Hydroxypropylcellulose Topical Films Produced by Hot-Melt Extrusion, J. Contr. Rel., 70, 341-351, (2001).
M. A. Repka and J.W. McGinity, Influence of Chlorpheniramine Maleate on Topical Films Produced by Hot-Melt Extrusion, Pharm. Dev. Tech.,6(3), 295–302 (2001).
J.W. McGinity, F. Zhang, M.A. Repka and J.J. Koleng, Hot-Melt Extrusion as a Pharmaceutical Process, American Pharmaceutical Review, 4(2), 25-36, (2001).
M. A. Repka and J.W. McGinity, Physical-Mechanical, Moisture Absorption and Bioadhesive Properties of HPC Hot-Melt Extruded Films, Biomaterials, 21 (14), 1509-1517, (2000).
M. A. Repka and J.W. McGinity, Influence of Vitamin E TPGS on the Properties of Hydrophilic Films Produced by Hot-Melt Extrusion, Int. J. Pharm., 202 (1-2), 63-70, (2000).
J.W. McGinity, F. Zhang, M.A. Repka and J.J. Koleng, Thermal Processing of Pharmaceutical Powders, Pharm Tech Japan, 16(6), 897-913, (2000).
M. A. Repka, T.G. Gerding, S. L. Repka, and J. W. McGinity, Influence of Plasticizers and Drugs on the Physical-Mechanical Properties of Hydroxypropylcellulose Films Prepared by Hot-Melt Extrusion, Drug Devel. Ind. Pharm., 25: 5, 627-635, (1999).
M.A. Repka, Physical-mechanical and chemical properties of topical films produced by hot-melt extrusion. The University of Texas at Austin: Austin, Texas, May, 2000.
R. O. Williams, M. K. Barron, and M. A. Repka, Application of co-grinding to formulate a model pMDI suspension, Eur. J. Pharm. Biopharm., 48:2 131-140, (1999).
R. O. Williams III, M. A. Repka, and Jie Liu, Influence of Propellant Composition on Drug Delivery from a Pressurized Metered-Dose Inhaler, Drug Devel. Ind. Pharm., 24:8 763-770, (1998).

Pre-1998 Peer Reviewed Paper:

M. A. Repka, RAU: Back to the Basics, Texas J Acad of General Dentistry,July, 1991.

Book Editor:

Melt Extrusion: Equipment and Pharmaceutical Applications, 1st ed., Ed: M. A. Repka & Nigel Langley, Springer Publishing Company, NY, accepted for publication and in preparation.

Invited Reviews and Book Chapters:

M. A. Repka, L. Chen, R. Chan, Buccal Drug Delivery, in: Controlled Release in Oral Medication, Ed: C. Wilson, B. Skalsky & P. Crowley, Controlled Release Society Publication, scheduled publish date, September 2011.
Upadhye S.B., Kulkarni S.J., Majumdar, S., Avery M.A., Gul W., ElSohly M.A., Repka M.A., Preparation and Characterization of Inclusion Complexes of a Hemisuccinate Ester Prodrug of Delta(9)-Tetrahydrocannabinol with Modified Beta-Cyclodextrins, AAPS PharmSciTech.(Invited Theme Edition) 2010 Jun;11(2):509-172.
M.A. Repka, S. Majumdar, S.K Battu, R. Srirangam, S. Upadhye, Applications of hot-melt extrusion for drug delivery.Expert Opin. Drug Deliv. 5(12), 1357-1376 (2008).
Repka, M.A., Crowley, M.M., Battu, S.K., Upadhye, S.B., Thumma, S., Zhang, F., Martin, C., McGinity, J. Pharmaceutical Applications of Hot-Melt Extrusion: Part II. Drug Development and Industrial Pharmacy (2007), 33(10), 1052-1066.
Crowley, M.M., Repka, M.A., Thumma, S., Upadhye, S.B., Battu, S.K., Zhang, F., Martin, C., McGinity, J. Pharmaceutical Applications of Hot-Melt Extrusion: Part I. Drug Development and Industrial Pharmacy (2007), 33(9), 909-926.
M. A. Repka, J. W. McGinity, F. Zhang, and J. J. Koleng, Hot-Melt Extrusion Technology, Encyclopedia of Pharmaceutical Technology, Ed: J. Swarbrick & J. Boylan, 2nd& 3rdEds., Marcel Dekker, Inc., NY, February (2002/2011).
M.A. Repka, M. Munjal, S. Prodduturi and P. Mididoddi, Matrix and Reservoir-Based Oral Transmucosal Systems: Tailoring Delivery Solutions. American J. Drug Delivery, 2(3), 2004.
J. W. McGinity, A. Singh and M. A. Repka, Alginic Acid, Handbook of Pharmaceutical Excipients, 4th Edition, American Pharmaceutical Association, November, (2003 & 2005 & 2009 & 2011).

INVITED LECTURES/SYMPOSIA/WORKSHOPS

Invited as Keynote Speaker and Presenter in the area of Hot Melt Extrusion by numerous global chemical/excipient/pharma companies. (meetings, symposia, workshops, and conferences)

Upcoming Presentations (Speaker): ThermoFisher, September 22nd and Evonik, December 6th, New Jersey.
Invited Speaker: Melt Extrusion-Case studies for DPT Labs, July 14, 2011, San Antonio, TX
Webinar: Hot Melt Extrusion for Solubilization, Ashland Aqualon, June 20, 2011.
Keynote Speaker: Hot Melt Extrusion: Process to Product, ExActMelt, Regional conference on "Hot melt extrusion", Singapore, June 15, 2011.
Invited Speaker: Hot Melt Extrusion Applications of BASF Polymers, ExActMelt, Regional conference on "Hot melt extrusion" co-sponsored by BASF, Singapore, June 15, 2011.
Invited Speaker: Hot Melt Extrusion in Controlled Drug Delivery, Modified Release Forum, Colorcon, West Point, PA, May 17, 2011.
Invited Speaker and Moderator: Hot Melt Extrusion for Manufacturing Pharmaceutical Dosage Forms, APV Experts Workshop on Hot-Melt Extrusion and its use in the manufacturing of pharmaceutical dosage forms, April 12-13, 2011,Tarrytown, NY.
Invited Speaker: Hot Melt Extrusion-Case studies for Continuous manufacturing, AAPS Workshop (MSE) on Advances and Opportunities in Drug Product Manufacturing, September 20-21, 2010, Baltimore, MD.
Invited Speaker: Taste Masking of Pediatric Solid Oral Formulations: New Opportunities using Hot-Melt Extrusion Technology, AAPS Short Course; Helping the Medicine Go Down – Pediatric Medicines: Formulation, Manufacturing and Compliance Challenges, AAPSAnnual Meeting and Exposition, November 15, 2010, New Orleans, LA.
Hot-Melt Extrusion: A Novel Oral Solids Processing Technology, AAPSAnnual Meeting and Exposition, Full Symposium Organizer and Speaker, November 12, 2009, Los Angeles, CA.
Invited Speaker: Stabilization of actives in hot-melt extruded PEO films, APV Experts Workshop on Hot-Melt Extrusion and its use in the manufacturing of pharmaceutical dosage forms, December 1-2, 2009. Ludwigshafen, Germany.
Invited Speaker: Melt Extrusion: Use of Polymer Blends for Processing of Insoluble Bioactives, GSK, January 20-21, 2010, Philadelphia, PA. Sponsored by BASF, ThermoFisher Scientific and GSK.
Invited Speaker: Melt Extrusion: Solubilization of Insoluble Bioactives, Bristol Myers Squib (BMS), May 11, 2010, New York, New York. Sponsored by BMS and BASF.
Invited Speaker: Melt Extrusion: Solubilization of Insoluble Bioactives, Teva/Barr, May 12, 2010, Princeton, N.J. Sponsored by ThermoFisher, BASF and Teva/Barr.
Invited Speaker: Melt Extrusion: New Pharmaceutical Applications, Boehringer Ingelheim, August 31, 2010, Princeton, N.J. Sponsored by BI.
Invited Speaker: Melt Extrusion: Solubilization Techniques for Generic Drugs, Abon Pharma, September 1, 2010, Tarrytown, N.Y.,Sponsored by BASF and Abon.
Invited Speaker: Advanced Solubilization Strategies using Melt Extrusion, Bend Pharmaceuticals, October 12, 2010, Bend, OR, Sponsored by Bend Pharma.
Hot-Melt Extrusion Technology Symposium, 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, March 8-11, 2010, Valletta, Malta.
Hot-Melt Extrusion of Polymer Blends and Sensitive Actives, Invited Speaker, Amgen, June 4-5, 2009, Thousand Oaks, CA. Workshop Sponsored by ThermoFisher Scientific and BASF.
Invited Speaker:Hot-Melt Extrusion: Use of Polymer Blends for Pharmaceutical Applications, 1st International Symposium for Industrial Pharmacy and Clinical Pharmacy, October 9-11, 2009, Guangzhou, China.
Invited Speaker: Melt Extruded Drug Delivery Systems via Polymer Blends, Pharmacy Lecture Seminar Series, The University of Wisconsin at Madison, September 17, 2009.
Invited Speaker: Paediatric medicines – Formulation, Manufacturing and Compliance Challenges and Strategies Moving Forward, AAPS 2010 Workshop, November, 2010, New Orleans, LA.
Melt Extrusion of Bioactives: Formulation, Processing and Manufacturing, Workshop Organizer, Organizer and Chair, 37th Annual Meeting and Exposition of the Controlled Release Society, July 10-14, 2010, Portland, Oregon.
Invited Speaker: Stabilization of actives in hot-melt extruded PEO films, APV Experts' Workshop on Hot-Melt Extrusion and its use in the manufacturing of pharmaceutical dosage forms, March 4-5, 2008. Ludwigshafen, Germany.
Evaluation of Buccal Delivery of Δ9-Tetrahydrocannabinol Prodrugs Utilizing Hot-Melt Processed Oral Transmucosal Patch Systems, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, April 7-10,2008, Barcelona, Spain.
Nano Symposia, Nano-particles, fibers and arrays: Potential applications to Hot-Melt Extruded Dosage Forms, December 7, 2006, Oak Ridge National Laboratories (ORNL), Oak Ridge, TN.
Invited Speaker, Dow and Thermo Electron Symposium & Workshop, May 2, 2006, Pharmaceutical Applications of HME, Princeton, NJ
Invited Speaker, Aqualon, Division of Hercules, Klucel Applications for Hot-Melt Extrusion, Wilmington, DE, May1, 2006.
Invited Speaker, 57th Indian Pharmaceutical Congress, Hot-Melt Extrusion: Pharmaceutical Applications, December 2, 2005, Hyderabad, India
Invited Oral Presentation, J. Morita Investigator Award Finalist, Geriatric Oral Research, 83rd General Session and Exhibition of the International Association of Dental Research, March 11th, 2005, Baltimore, MD (First Place)
Invited Speaker, Eastern Pharmaceutical Technology Meeting, "Hot-melt Extrusion Technology for Pharmaceutical Applications", Princeton, NJ, September 16, 2005.
Invited Speaker, Proctor & Gamble, "Hot-Melt Extrusion: Bioavailability Considerations", May 19, 2005.
Invited Speaker, MTA & MRC IP Forum, "Bioadhesive Film Technology Platform", December 1, 2004, Jackson, MS.
Invited Speaker, SouthEast Expo Intellectual Property Forum, New Frontiers in Therapeutics, "Bioadhesive Film Technology Platform", RTP, NC, Oct. 6, 2004.
Invited Chair of Oral Symposium on Dental Care Delivery Systems at the International Association of Dental Research (IADR) Annual Meeting; 'Tooth Whitening/Fluoride/Delivery Systems', M.A. Repka, Session 158, Honolulu, Hawaii (March 11, 2004)
"Oral Care and Bioadhesive Film Technology Platform", M. A. Repka, The National Center for Natural Products Research, Wyeth Pharmaceuticals and Consumer Health Care, January 2004
"Assessing Tetrahydrocannabinol (THC) Pro-drugs in Transmucosal Patch Delivery Formulations for the Treatment of Neuropathological Conditions", M. A. Repka, Center for Psychiatric Neuroscience at UMMC, CPN Advisory Board Annual Meeting, September 2003
"New Drugs and Novel Therapy Systems for Oral Cavity OI", M. A. Repka, The University of Southern Mississippi, IGERT Proposal Board Meeting, April 2003
Invited Lecturer: "Trans" Drug Delivery Systems, M.A. Repka, Schering-Plough, Memphis, TN, October 2002
Invited Lecturer: "Thermal Processing of Pharmaceutical Powders", M.A. Repka,The University of Texas College of Pharmacy, November 5, 2001
Invited Lecturer:"The Human Skin, Nail, Hair and Mucosa: Influences on Drug Delivery",M.A. Repka, Schering-Plough, Memphis, TN, October 2001
Invited Lecturer: "Hot-Melt Extrusion—An Overview", M.A. Repka, The University of Texas College of Pharmacy, September 25, 2000

PATENTS/PATENTS PENDING

M. A. Repka, S.L. Repka and J.W. McGinity, Bioadhesive Hot-Melt Extruded Film for Topical and Mucosal Adhesion Applications and Drug Delivery and Process for Preparation Thereof, U.S. Patent, No. 6,375,963, (2002).

M. A. Repka, Delivery of medicaments to the nail and perionychium. Patent granted July 2011, pending patent number.

M. A. Repka and T.G. Gerding, Bioadhesive Polyethylene Glycol Ointment for Medicaments, U.S. Patent, No. 5,714,165, (1998).

M. A. Repka and T.G. Gerding, Polyethylene Glycol Ointment for Aphthous Ulcers, U.S. Patent, No. 5,112,620, (1992).

M.A. Repka: Three Patents Pending

1.) Alternative delivery systems for THC and derivatives (Cannabinoids). Inventors: M.A. Repka and M.A. ElSohly, PCT filing submitted April, 2003.

2.) Stabilization of Triamcinolone Acetonide formulations. Inventors: M.A. Repka, et al. Patent submitted May 2007.

3.) Synthesis of Novel Amino Acid Prodrugs of THC. Inventors: M.A. ElSohly, S. Majumdar, M.A. Repka. Submitted October 2008.

ABSTRACT PRESENTATIONS AT NATIONAL AND INTERNATIONAL CONFERENCES

N. Mohammed, A. Singh, S. Majumdar, E. Pinto, D. Tewari, T. Durig, M. A. Repka. 'Tablets manufactured via HME as a processing technique for solubility enhancement: Stability assessment and in vitro release comparison to a marketed formulation' AAPS Annual Meeting and Exposition, October 2011, Washington, DC.
W. Deng, A. Singh, S. Jo, S. Majumdar, E. Pinto, D. Tewari, T. Durig, M. A. Repka. 'In vitro evaluation of hydroxypropylcellulose immediate-release tablets produced by melt extrusion technology' AAPS Annual Meeting and Exposition, October 2011, Washington, DC.
W. Deng, S. Majumdar, K. Kolter, N. Langley, M. A. Repka. 'Development and characterization of fenofibrate immediate release tablets prepared via melt extrusion utilizing Kollidon® VA 64' AAPS Annual Meeting and Exposition, October 2011, Washington, DC.
A. Singh, W. Deng, N. Mohammed, S. Shah, S. Majumdar, E. Pinto, D. Tewari, T. Durig, M. A. Repka. 'Preparation and characterization of solid dispersion tablets of Efavirenz with Benecel™ E5 PH' AAPS Annual Meeting and Exposition, October 2011, Washington, DC.
A. Singh, W. Deng, N. Mohammed, S. Shah, S. Majumdar, E. Pinto, D. Tewari, T. Durig, M. A. Repka. 'Characterization of hot melt extruded immediate release solid dosage forms with cellulose ether polymers for a poorly soluble drug' AAPS Annual Meeting and Exposition, October 2011, Washington, DC.
A. Singh, W. Deng, N. Mohammed, S. Shah, S. Majumdar, M. A. Repka. 'Development of taste masked tablets with Eudragit® E PO utilizing melt extrusion' AAPS Annual Meeting and Exposition, October 2011, Washington, DC.
S. Maddineni, J. Morott, S. Murthy, S. Majumdar, M. A. Repka. 'Hot Melt Extrusion: A Promising Technique to Produce Novel Abuse Deterrent and/or Tamper-Resistant Formulations' AAPS Annual Meeting and Exposition, October 2011, Washington, DC.
S. Maddineni, J. Morott, S. Murthy, S. Majumdar, K. Kolter, N. Langley, M. A. Repka. 'Influence of Surfactants on Drug Release from the Miscible Soluplus®-Curcumin Hot Melt Extrudates' AAPS Annual Meeting and Exposition, October 2011, Washington, DC.
J. Lu, S. Shah, S. Jo, M. A. Repka. 'Solubility Enhancement and Precipitation Inhibition of Paclitaxel Using Hot Melt Extrusion Technology' AAPS Annual Meeting and Exposition, October 2011, Washington, DC.
J. Lu, A. S. Alshetaili, S. Shah, S. Majumdar, K. Kolter, N. Langley, M. A. Repka. 'Influence of Formulation Factors and Processing Parameters on Chemical Properties of Ketoconazole-Soluplus® Melt Extrudates Using Response Surface Methodology' AAPS Annual Meeting and Exposition, October 2011, Washington, DC.
K. Patwardhan, S. Shah, S. Majumdar, K. Kolter, N. Langley, M. A. Repka. 'Comparative drug-polymer miscibility of Ketoconazole in different grades of PVP polymers' AAPS Annual Meeting and Exposition, October 2011, Washington, DC.
K. Patwardhan, S. Alshahrani, S. Shah, E. Pinto, D. Tewari, T. Durig, S. Majumdar, M. A. Repka. 'Taste Masking Performance of Two Grades of Hydroxypropylcellulose Melt Extruded Pellets' AAPS Annual Meeting and Exposition, October 2011, Washington, DC.
J. Lu, S. Shah, S. Jo, M. A. Repka. 'Solubility Enhancement and Precipitation Inhibition of Paclitaxel Using Hot Melt Extrusion Technology' AAPS Annual Meeting and Exposition, October 2011, Washington, DC.
S. Shah, S. Jain, K. Sawant, S. Sathaye, R. Patole, P. Amin, M. A. REPKA. 'Characterization and Functional Evaluation of Novel Granular Grades of Carbomers' AAPS Annual Meeting and Exposition, October 2011, Washington, DC.
Michael A. Repka, Sindhuri Maddineni, Jiannan Lu, Sejal Shah, Soumyajit Majumdar, Karl Kolter, Nigel Langley 'Kollidon® VA 64: A vital polymer for fast dissolving hot-melt extruded dosage forms' Controlled Release Society Annual Meeting and Exposition, National Harbor, MD, August 2011.
Michael A. Repka, Abhilasha Singh, Weibin Deng, Noorullah Naqvi Mohammed, Sejal Shah, Soumyajit Majumdar, Elanor Pinto, Divya Tiwari and Thomas Durig 'Solubilization of a lipophilic bioactive in hydroxypropylcellulose (Klucel® HPC) solid matrix dispersions via hot melt extrusion' Controlled Release Society Annual Meeting and Exposition, National Harbor, MD, August 2011.
J. Lu, S. Jo, M. A. Repka. 'Preparation of a Solid Dispersion Matrix for Paclitaxel with Nanoclays' AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
J. Lu, S. Majumdar, K. Kolter, N. A. Langley, M. A. Repka. 'Influence of Kollidon® VA64 and Soluplus® blends on lidocaine release from hot-melt extruded pellets'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
J. Lu, K. Kolter, N. A. Langley, M. A. Repka. 'Influence of Kollidon® VA64/Soluplus® blends and Process Parameters on Chemical Stability of Hot-melt Extruded Lidocaine Pellets'.AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
J. Lu, M. A. Repka. 'Influence of Nanoclays on the Bioadhesive and Mechanical Properties of Hot-Melt Extruded Films'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
S. Maddineni, Sunil Kumar Battu, Karl Kolter, Nigel A. Langley, Michael A. Repka. 'Formulation, Evaluation and Comparison of Nifedipine Hot-Melt Extruded Tablets'.AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
S. Maddineni, Sunil Kumar Battu, Karl Kolter, Nigel A. Langley, Michael A. Repka. 'Influence of Drug Load on Release and Stability Of Soluplus-clotrimazole Hot-Melt Extrudates'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
S. Maddineni, Sunil Kumar Battu, Karl Kolter, Nigel A. Langley, Michael A. Repka. 'Influence of Formulation and Process Parameters on the Miscibility of Soluplus-Clotrimazole Hot-Melt Extrudates'.AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
A.Singh, S. Majumdar, M. A. Repka. 'Sugar alcohols as carriers for solid dispersion using melt extrusion technique'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
A.Singh, S. Majumdar, M. A. Repka. 'Sustained release from EthocelTM matrix pellets using processing aids in melt extrusion'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
A.Singh, N. Mohammed, W. Deng, S. Majumdar, E. Pinto, T. Durig, M. A. Repka. 'Characterization of Solid Dispersions of efavirenz in Klucel ®EF, Klucel® EXF and Klucel ®ELF matrix prepared using melt extrusion technology'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
Weibin Deng, Abhilasha Singh, Soumyajit Majumdar, Michael A. Repka. 'Development and Characterization of Hot-MeltExtruded Films Containing Berberine Hydrochloride'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
Weibin Deng, Abhilasha Singh, Soumyajit Majumdar, Michael A. Repka. 'Stabilization of Fenofibrate in Low MolecularWeight Klucel Matrices Utilizing Polymeric Blends'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
Weibin Deng, Abhilasha Singh, Soumyajit Majumdar, Michael A. Repka. 'Development and Evaluation of a Hot-MeltExtruded Oral Delivery System of Carbamazepine Prepared with aPolymeric Blend of Kollidon VA 64 and Klucel EF'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
Weibin Deng, Abhilasha Singh, Seongbong Jo, Soumyajit, Majumdar, Elanor Pinto, Thomas Durig, Michael A. Repka. 'Solubility Enhancement of Fenofibrate by LowMolecular Weight Klucel Matrices Produced by Melt Extrusion'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
K. Patwardhan, S. Majumdar, M. A. Repka. 'Development of a Povidone Iodine Film via Hot Melt Extrusion for Wound Healing Applications'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
K. Patwardhan, K. Kolter, N. Langley, S. Majumdar, M. A. Repka. 'Mechanistic studies of an insoluble drug from Kollidon® VA 64 melt extrudates'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
K. Patwardhan, K. Kolter, N. Langley, S. Majumdar, M. A. Repka. 'Influence of a superdisintegrant and hot melt processing methods on physical properties and drug release from Kollidon® VA 64 matrix tablets'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
Sampada Upadhye, S. Majumdar, W.Gul, M.A. ElSohly, M. A. Repka. 'Application of factorial design to identify critical formulation variables in the design of hot-melt cast mucoadhesive films of a delta-9-tetrahydrocannabinol prodrug' AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
Sampada Upadhye, S. Majumdar, K. Patwardhan, W.Gul, M.A. ElSohly, M. A. Repka. 'Transmucosal Delivery of a hemisuccinate ester prodrug of delta-9-tetrahydrocannabinol: Synergistic effect of formulation additives and modified cyclodextrins'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
N. Mohammed, A. Singh, E. Pinto, T. Durig, M. A. Repka. 'Immediate release formulations for oral delivery of a poorly water soluble drug utilizing Klucel® EF and Klucel® ELF polymer matrices'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
N. Mohammed, E. Pinto, T. Durig, M. A. Repka. 'Design of an immediate release tablet formulation for oral delivery of a poorly soluble drug Ketoprofen'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
Mohammed, E. Pinto, T. Durig, M. A. Repka. 'Influence of Hot melt extruded matrices on tabletting characteristics of directly compressed immediate release tablets of Ketoprofen'. AAPS Annual Meeting and Exposition, November 2010, New Orleans, LA.
M.A. Repka, Hot-Melt Extrusion: A Novel Oral Solids Processing Technology, AAPSAnnual Meeting and Exposition, Full Symposium Organizer and Speaker, November 12, 2009, Los Angeles, CA.
S. Battu, R. Ziyaur, S. Majumdar, W. Gul, M. A. ElSohly, M. A. Repka. 'In vitro and In vivo Characterization of a Novel Amino Acid Ester Prodrug of Delta-9-Tetrahydrocannabinol, Delta-9-THC Valinate'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract# 1843).
N. Mohammed, A. Singh, K. Patwardhan, M. A. Repka. 'Influence of Klucel® and Eudragit® blends on the release of a water soluble model drug in hot-melt extrudates'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract# 3220).
K. Patwardhan, K. Kolter, N. A. Langley, M.A. Repka 'Influence of Kollidon® VA 64 on the release profiles of Carbamazepine from hot-melt extruded films'..AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract # 3307)
S. Maddineni, S. Battu, K. Kolter, N. A. Langley, M. A. Repka. 'Effect of Processing Conditions on Stability and Drug Release from Nifedipine--Kollidon® VA 64 Hot-Melt Extrudates'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract# 3334)
S. B. Upadhye, S. Majumdar, W. Gul, M. ElSohly, M. A. Repka. 'Influence of modified cyclodextrins on the mechanical properties and bioadhesion of hot-melt extruded polyethylene oxide transmucosal films containing a delta-9-tetrahydrocannabinol prodrug'.AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract # 3350).
S. B. Upadhye, S. Majumdar, W. Gul, M. ElSohly, M. A. Repka. 'Dissolution behavior of solid dispersions of a delta-9-tetrahydrocannabinol prodrug and modified cyclodextrins'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract # 3378).
A. Singh, M. N. Mohammed, K. Patwardhan, M. A. Repka. 'Preformulation studies for hot-melt extrusion of selected polymers using thermal analysis and FTIR spectroscopy'.AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract# 3400).
A. Singh, M. N. Mohammed, K. Patwardhan, M. A. Repka.'Mechanical properties and moisture content of polymer blends as a function of plasticizer concentration formulated using hot-melt extrusion'.AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA.(Abstract# 3415).
A. Singh, M. N. Mohammed, K. Patwardhan, M. A. Repka. 'Development of Transmucosal Drug Delivery System containing Polyethylene oxide and Eudragit EPO as a release modifier utilizing hot-melt extrusion techniques: Effect of levels of release modifying polymer and plasticizers'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract# 3416).
N. Mohammed, A. Singh, K. Patwardhan, M. A. Repka. 'Efficacy of twin-screw hot-melt extrusion processing over hot-melt casting methods for formulating transmucosal films with polymer blends' .AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract# 3419).
S. Battu, T. Hingorani, R. Ziyaur, S. Majumdar, W. Gul, M. A. ElSohly, M. A. Repka. 'Preformulation Characterization of a Novel Delta-9 tetrahydrocannabinol-Amino Acid-Dicarboxylic Acid Prodrug, THC-Val-HS'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract# 3482).
S. Maddineni, S. Battu, K. Kolter, N. A. Langley, M. A. Repka.'Influence of Processing aids and Process Parameters on Post-Processing Content of Nifedipine--Kollidon® VA 64 Hot-Melt Extrudates'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract# 3504).
K. Patwardhan, A. Singh, N. N. Mohammed, M.A. Repka. 'Investigation of Eudragit® EPO as a release modifier utilizing hot-melt extrusion for novel drug delivery systems: Effect of pH modifiers'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract # 3680).
W. Deng, S. Maddineni, J. Lu, T. Hingorani, S. Majumdar, M.A. Repka. 'Formulation and in Vitro Evaluation of a Sustained Release System of Promethazine Hydrochloride using Eudragit® and Poly (Ethylene Oxide) Blends'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract# 3746).
S. Battu, R. Ziyaur, S. Majumdar, W. Gul, M. A. ElSohly, M. A. Repka.'Solubility and Stability Characteristics of Novel Amino Acid Ester Prodrugs of Delta-9-Tetrahydrocannabinol: A Comparative Study based on polarity of the molecule'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract# 3853).
S. Battu, S. Majumdar, S. Maddineni, A. G. Chittiboyina, M. A. Repka. 'Characterization of Berberine Chloride-2-hydroxypropyl-beta-cyclodextrin Complexes'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract# 3865).
S. Battu, S. Maddineni, S. Majumdar, W. Gul, M. A. ElSohly, M. A. Repka. 'Influence of drug load on bioadhesive properties and stability of hot-melt extruded formulations containing a Delta-9-Tetrahydrocannabinol dicarboxylic acid ester prodrug' .AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract# 3877).
S. Battu, S. Maddineni, S. Majumdar, W. Gul, M. A. ElSohly, M. A. Repka. 'Effect of Drug Load on Release Properties of Hot-Melt Extruded Formulations Containing a Delta-9-Tetrahydrocannabinol Dicarboxylic Acid Ester Prodrug'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract# 3894).
W. Deng, J. Lu, S. Maddineni, T. Hingorani, S. Majumdar, M. A. Repka. 'Influence of Eudragit® RS PO and Processing Conditions of Hot-Melt Extrusion on Drug Stability and Dissolution Properties'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA (Abstract# 3918).
W. Deng, J. Lu, S. Maddineni, T. Hingorani, S. Majumdar, M. A. Repka. 'Influence of Plasticizers on the Release of Promethazine HCl from Hot-Melt Eudragit® RS PO and Poly (Ethylene Oxide) Polymeric Matrix Blends'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA (Abstract# 3947).
N. Mohammed, Z. Rahman, W. Gul, S. Majumdar, M. A. ElSohly, M. A. Repka. 'To characterize the lipophilicity of various prodrugs of delta-9-tetrahydrocannabinol (THC) using a reverse phase HPLC method and its comparison with software generated values'.AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract# 3952).
J. Lu, W. Deng, S. Maddineni, T. Hingorani, S. Jo, S. Majumdar, M.A.Repka. 'Eudragit RSPO and PEO Blends on the Bio-adhesive and Mechanical Properties of Hot melt Extruded Films'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract # 5401).
J.Lu, J.Zhou, M.A Repka. 'Preparation and Characterization of Bovine Serum Albumin loaded Chitosan Self assembled Nanomicelles'. AAPS Annual Meeting and Exposition, November 2009, Los Angeles, CA. (Abstract # 6302).
M.A. Repka, Evaluation of Buccal Delivery of Δ9-Tetrahydrocannabinol Prodrugs Utilizing Hot-Melt Processed Oral Transmucosal Patch Systems, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, April 7-10,2008, Barcelona, Spain.
M.A. Repka, Invited Speaker: Stabilization of actives in hot-melt extruded PEO films, APV Experts Workshop on Hot-Melt Extrusion and its use in the manufacturing of pharmaceutical dosage forms, March 4-5, 2008. Ludwigshafen, Germany.
S. Jo, J.K. Kim, J. Anderson, H.W. Jun, M.A. Repka, Self-assembling peptide amphiphile-based nanofiber gel for bioresponsive cisplatin delivery, Society for Biomaterials-Annual Meeting and Exposition: Giving Life to a world of materials, San Antonio, TX, April 2009.
S. Jo, J.K. Kim, J. Anderson, H.W. Jun, M.A. Repka, A self-assembled peptide amphiphile nanofiber matrix as a bioresponsive cisplatin delivery system, International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT,February 2009.
S. Upadhye, S. Majumdar, S. Kulkarni, M.A. Avery, W. Gul, M.A. ElSohly, M.A. Repka, Improving solubility and stability of hemisuccinate ester prodrug of delta-9-tetrahydrocannabinol with cyclodextrin complexation, Annual Neuroscience and Behavior Research Day, Jackson, MS, December 2008.
S. Battu, Z. Rahman, S. Majumdar, W. Gul, M.A. ElSohly, M.A. Repka, Evaluation of a novel delta-9 tetrahydrocannabinol prodrug, ELI-UN1-88-4, Annual Neuroscience and Behavior Research Day, The University of Mississippi School of Medicine, Jackson, MS, December 2008.
S. Upadhye, S. Majumdar, W. Gul, M.A. ElSohly, M.A. Repka, The influence of inclusion complex formation with random methylated beta cyclodextrin (RAMEB) on thermal stability and permeation characteristics of the hemisuccinate ester prodrug of delta-9-tetrahydrocannabinol,AAPS Annual Meeting and Exposition, Atlanta, GA, November 2008.
S. Upadhye, S. Majumdar, S. Kulkarni, M.A. Avery, W. Gul, M.A. ElSohly, M.A. Repka, Preparation and characterization of an inclusion complex of a hemisuccinate ester prodrug of delta-9-tetrahydrocannabinol with modified beta-cyclodextrins, AAPS Annual Meeting and Exposition, Atlanta, GA, November 2008.
S. Upadhye, S. Majumdar, T. Jefferson, W. Gul, M.A. ElSohly, M.A. Repka, Preformulation characterization of a prodrug of delta-9 tetrahydrocannabinol (THC-XIX645), AAPS Annual Meeting and Exposition, Atlanta, GA, November 2008.
S. Battu, S. Majumdar, M.A. Repka, Evaluation of physicochemical properties of berberine chloride, AAPS Annual Meeting and Exposition, Atlanta, GA, November 2008.
S. Battu, Z. Rahman, S. Majumdar, W. Gul, M.A. ElSohly, M.A. Repka, Effect of pH and 2-hydroxypropyl-β-cyclodextrin on solubility of ∆9-tetrahydrocannabinol and two novel pro-drugs, ELI-UN1-88-4 and ELI-UN1-89-2, AAPS Annual Meeting and Exposition, Atlanta, GA, November 2008.
S. Battu, N. Mohammed, M.A. Repka, Influence of drug load and powder flow properties on content uniformity of actives prior to, during and after hot-melt extrusion, AAPS Annual Meeting and Exposition, Atlanta, GA, November 2008.
S. Battu, N. Mohammed, W. Deng, M. A. Repka, Influence of extruder type on content uniformity and effect of plasticizer load on drug release of hot-melt extruded polyethylene oxide films, AAPS Annual Meeting and Exposition, Atlanta, GA, November 2008.
A. Singh, S. Upadhye, M.A. Repka,Effect of modified cyclodextrin on hot-melt extruded films containing clotrimazole produced by twin-screw extrusion technology,AAPS Annual Meeting and Exposition, Atlanta, GA, November 2008.
S. Thumma, A. Singh, S. Majumdar, M.A. ElSohly, W. Gul, M.A. Repka, Enhancement of the dissolution and handling properties of an ester prodrug of Δ9-tetrahydrocannabinol by a solid dispersion technique,AAPS Annual Meeting and Exposition, Atlanta, GA, November 2008.
N.N. Mohammed, Z. Rahman, M.A. Repka, Clotrimazole 2-hydroxy propyl beta cyclodextrin complex for vaginal delivery, AAPS Annual Meeting and Exposition, Atlanta,GA, November 2008.
W, Deng, A. Singh, S.K. Battu, N.N. Mohammed, S. Jo, M.A. Repka, Bioadhesive Properties of hot-melt extruded films containing lidocaine HCl, metformin HCl and prochlorperazine maleate, AAPS Annual Meeting and Exposition, Atlanta, GA, November 2008.
A. Singh, W. Deng, S. K. Battu, N. N. Mohammed, S. Joand M.A. Repka,Influence of drug &drug load on the mechanical properties of hot-melt extruded polyethylene oxide films,AAPS Annual Meeting and Exposition, Atlanta, GA, November 2008.
S. Thumma, W. Deng, S. Majumdar, M.A. ElSohly, W. Gul, M.A. Repka, Influence of plasticizers on the release of a Δ9-tetrahydrocannabinol prodrug incorporated in poly (ethylene oxide) matrices, AAPS Annual Meeting and Exposition, Atlanta, GA, November 2008.*
Z. Rahman, S. Battu, S. Majumdar, W. Gul, M.A. ElSohly, M.A. Repka, Physicochemical characterization of a novel delta-9 tetrahydrocannabinol prodrug, ELI-UN1-88-4, AAPS Annual Meeting and Exposition, Atlanta, GA, November 2008.
Z. Rahman, S. Battu, S. Majumdar, W. Gul, M. A. ElSohly, M. A. Repka, Chemical, enzymatic and thermal stability of a novel delta-9 tetrahydrocannabinol prodrug, ELI-UN1-88-4, AAPS Annual Meeting and Exposition, Atlanta, GA, November 2008.
K. Hippalgaonkar, W. Gul, M. Elsohly, M.A. Repka,S. Majumdar,Effect of surfactants and cyclodextrins on aqeous solubility and stability of delta-8 Tetrahydrocannabinol,AAPS Annual Meeting and Exposition, Atlanta, GA, November2008.*
J.K. Kim, J. Anderson, H.W Jun, M.A. Repka, S. Jo, Nanofiber networked gel formulation based on a self-assembling peptide amphiphile for targeted delivery of cisplatin,AAPS Annual meeting and Exposition, Atlanta, GA, November 2008.
W. Deng, A. Singh, S.K. Battu, N.N. Mohammed, S. Jo, M.A. Repka, Bioadhesive properties of hot-melt extruded films containing lidocaine HCl, metformin HCl and prochlorperazine maleate, NCNPR Annual Poster Session, University, MS, October 2008.
A. Singh, W. Deng, S.K. Battu, N.N. Mohammed, S. Jo,M.A. Repka, Influence of drug &drug load on the mechanical properties of hot-melt extruded polyethylene oxide films,NCNPR Annual Poster Session, University, MS, October 2008.
S. Upadhye, A. Singh, S. Majumdar, M.A. Repka, Effect of random methylated beta cyclodextrin on aqueous solubility, stability and permeation of the hemisuccinate ester of delta-9-tetrahydrocannabinol, NCNPR Annual Poster Session, University, MS, October 2008.
S. Battu, Z. Rahman, S. Majumdar, W. Gul, M.A. ElSohly, M.A. Repka, Preformulation studies of a novel delta-9 tetrahydrocannabinol prodrug, 2nd Biennial National IDeA Symposium of Biomedical Research Excellence (NISBRE), Washington, DC, August 2008.
D. Tewari, S. Battu, R.K. Lewis, W.W. Harcum, T. Dϋrig, Effect of hypromellose and methylcellulose substitution type, molecular weight and drug solubility on release kinetics from matrix tablets, Controlled Release Society Annual Meeting and Exposition, New York City, NY, July 2008
S. Thumma, W.Deng, M.A. Repka, HPLC method development and validation for determination of promethazine hydrochloride in hot-melt extruded polymeric matrices, SRDG-PharmForum, Little Rock, AR, May 2008.
S. Thumma, A. Singh, S. Majumdar, M.A. ElSohly, W. Gul,M.A. Repka, Evaluation of non-ionic surfactants for transmucosal delivery of a pro-drug of Δ9-tetrahydrocannabinol, SRDG-PharmForum, Little Rock, AR, May 2008.
S. Thumma, A. Singh, S. Majumdar, M.A. ElSohly, W. Gul,M.A. Repka, Evaluation of non-ionic surfactants for transmucosal delivery of a pro-drug of Δ9-tetrahydrocannabinol,Sigma-Xi Poster Symposium, University, MS, April 2008.
S. Upadhye, S. Majumdar, W. Gul, M.A. ElSohly, M.A. Repka, Preformulation Evaluation of THC Prodrugs, Sigma-Xi Poster Symposium, University, MS, April 2008.
S. Majumdar, S. Upadhye, S. Thumma, S. Battu, W. Gul, M.A. ElSohly, Z. Rahman, M.A. Repka, Evaluation of buccal delivery of tetrahydrocannabinol pro-drugs utilizing hot-melt processed oral transmucosal patch systems, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain, April 2008.
S. Thumma, S. Majumdar, M. A. ElSohly and M. A. Repka, Chemical Stability of a Pro-Drug of Delta-9-Tetrahydrocannabinol: Effect of Processing Variables and Plasticizers, The AAPS Journal Supplement, Volume 9, Issue S2, M1271, Annual AAPS National Meeting, November 2007, San Diego.
S. Thumma, M. A. ElSohly and M. A. Repka, Bioadhesive Properties of Hot-Melt Produced Poly (Ethylene Oxide) Films for Transmucosal Delivery of a Pro-Drug of Delta-9-Tetrahydrocannabinol, The AAPS Journal Supplement, Volume 9, Issue S2, M1272, Annual AAPS National Meeting, November 2007, San Diego.
S. Thumma, M. A. ElSohly and M. A. Repka, Transmucosal Delivery of a Pro-drug of Delta-9-Tetrahydrocannabinol: Effect of Formulation additives, The AAPS Journal Supplement, Volume 9, Issue S2, M1263, Annual AAPS National Meeting, November 2007, San Diego.
S. Thumma, A. Singh, M. A. ElSohly and M. A. Repka, Evaluation of Non-ionic Surfactants for Transmucosal Delivery of a Pro-drug of Delta-9-Tetrahydrocannabinol, The AAPS Journal Supplement, Volume 9, Issue S2, M1273, Annual AAPS National Meeting, November 2007, San Diego
S. Thumma, N. N. Mohammed and M. A. Repka, Characterization of Hot-Melt Extruded Films for Transmucosal Delivery of Promethazine Hydrochloride, The AAPS Journal Supplement, Volume 9, Issue S2, M1270, Annual AAPS National Meeting, November 2007, San Diego.
S. Thumma, N. N. Mohammed and M. A. Repka, Thermal Analysis of Promethazine Hydrochloride for Incorporation into Hot-Melt Extruded Poly (Ethylene Oxide) Matrices, The AAPS Journal Supplement, Volume 9, Issue S2, M1274, Annual AAPS National Meeting, November 2007, San Diego.
S. Thumma, W. Deng and M. A. Repka, HPLC Method Development and Validation for Determination of Promethazine Hydrochloride in Hot-Melt Extruded Polymeric Matrices, The AAPS Journal Supplement, Volume 9, Issue S2, M1260, Annual AAPS National Meeting, November 2007, San Diego.
S. Majumdar, S. Upadhye, S. Thumma, S. Battu, W. Gul, M. A. ElSohly and M. A. Repka, Evaluation of transbuccal delivery of tetrahydrocannabinol using hot-melt extruded transmucosal patch systems, The AAPS Journal Supplement, Volume 9, Issue S2, M1247, Annual AAPS National Meeting, November 2007, San Diego.
M. Repka, S. Majumdar, S. Thumma, Q. Moore, L. Johnson and L. McDaniel, Hot-Melt Processed Poly (Ethylene Oxide) Matrices Incorporated with PspA Elicits Protective Immunity against Streptococcus pneumoniae, The AAPS Journal Supplement, Volume 9, Issue S2, T3361, Annual AAPS National Meeting, November 2007, San Diego.
S. Upadhye, A. Singh, S. Majumdar and M. A. Repka, Effect of random methylated beta cyclodextrin on aqueous solubility, stability and permeation of the hemisuccinate ester of Delta-9-tetrahydrocannabinol, The AAPS Journal Supplement, Volume 9, Issue S2, M1293, Annual AAPS National Meeting, November 2007, San Diego.
S. Battu, S. Boddu, S. Majumdar and M. A. Repka, Effect of Processing Conditions and Formulation Additives on Chemical Stability of a Δ9–Tetrahydrocannabinol Prodrug in Polymeric Matrices Produced by a Hot-Melt Method, The AAPS Journal Supplement, Volume 9, Issue S2, M1314, Annual AAPS National Meeting, November 2007, San Diego.
S. Majumdar, K. Hippalgaonkar, R. Srirangam and M. A. Repka, Effect of topical instillation of chitosan on intraocular pressure and corneal permeability in the rabbit model, The AAPS Journal Supplement, Volume 9, Issue S2, T3198, Annual AAPS National Meeting, November 2007, San Diego.
K. Hippalgaonkar, R. Srirangam, S. Majumdar, W. Gul, M. A. ElSohly and M. A. Repka, Physicochemical properties of delta-8 tetrahydrocannabinol, The AAPS Journal Supplement, Volume 9, Issue S2, W4308, Annual AAPS National Meeting, November 2007, San Diego.
S. Thumma, M. A. ElSohly and M. A. Repka, Preformulation Studies of a Pro-drug of Delta-9-Tetrahydrocannabinol, The AAPS Journal Supplement, Volume 8 Issue S2, W4112, Annual AAPS National Meeting, October/November 2006, San Antonio, TX.
S. Thumma and M. A. Repka, Characterization of Controlled Release Matrix Tablets Containing a Water-Soluble Drug, The AAPS Journal Supplement, Volume 8 Issue S2, T3198, Annual AAPS National Meeting, October/November 2006, San Antonio, TX.
S. Thumma and M. A. Repka, Screening of Commonly Used Excipients for Compatibility with Promethazine Hydrochloride, The AAPS Journal Supplement, Volume 8 Issue S2, W4108, Annual AAPS National Meeting, October/November 2006, San Antonio, TX.
S. Thumma and M. A. Repka, Evaluation of a Hot-Melt Extruded Mucoadhesive Matrix Formulation Containing a Water-Soluble Drug: Effect of Screw Speed, The AAPS Journal Supplement, Volume 8 Issue S2, W4118, Annual AAPS National Meeting, October/November 2006, San Antonio, TX.
S. Battu, M. Yamsani, M. Soumyajit, M. A. Repka, Formulation and Evaluation of Rapidly Disintegrating Fenoverine Tablets, The AAPS Journal Supplement, Volume 8 Issue S2, T3206, Annual AAPS National Meeting October/November 2006, San Antonio, TX.
S. Battu, M. A. Repka, M. Yamsani, In Vivo Evaluation of Disintegration Time and Taste of Fenoverine Rapidly Disintegrating Tablets, The AAPS Journal Supplement, Volume 8 Issue S2, W4111, Annual AAPS National Meeting October/November 2006, San Antonio, TX.
M. Munjal, S. Upadhye, M. ElSohly, M. A. Repka, Effect of Formulation and Physiological Variables on Permeation of ∆9 - Tetrahydrocannabinol, The AAPS Journal Supplement, Volume 8 Issue S2, W4320, Annual AAPS National Meeting October/November 2006, San Antonio, TX.
M. Munjal, S. Battu, M. ElSohly, M. A. Repka, Mechanistic Understanding of Dissolution Properties of Physical Mixtures and Hot – Melt Polyethylene Oxide Matrices Containing ∆9 -Tetrahydrocannabinol, The AAPS Journal Supplement, Volume 8 Issue S2, W5280, Annual AAPS National Meeting October/November 2006, San Antonio, TX.
M. Munjal, S. Thumma, M. ElSohly, M. A. Repka, Factors Affecting Oxidation of ∆9- Tetrahydrocannabinol in Hot – Melt Polymeric Films, The AAPS Journal Supplement, Volume 8 Issue S2, R6108, Annual AAPS National Meeting October/November 2006, San Antonio, TX.
M. Munjal, S. Majumdar, M. ElSohly, M. A. Repka, Reduced Oxidation of ∆9 -Tetrahydrocannabinol in Hot -Melt Polyethylene Oxide - Vitamin E Succinate Films Utilizing Anti-Oxidants, The AAPS Journal Supplement, Volume 8 Issue S2, R6112, Annual AAPS National Meeting October/November 2006, San Antonio, TX.
S. Upadhye, M. A. Repka, S. R. Kulkarni, Formulation and Characterization of Chlorophyllin Gels for Wound Healing Potential, The AAPS Journal Supplement, Volume 8 Issue S2, T3162, Annual AAPS National Meeting, October/November 2006, San Antonio, TX.
S. Upadhye, M. A. Repka, S. R. Kulkarni, Extraction, Isolation and Standardization of Chlorophyll 'a' from Spinach Leaf, The AAPS Journal Supplement, Volume 8 Issue S2, W4101, Annual AAPS National Meeting, October/November 2006, San Antonio, TX.
P. K. Mididoddi, S. Trey, D. A. Wicks, M. A. Repka, Characterization of Hot-Melt Extruded Hydroxypropyl Cellulose Films Containing Itraconazole, The AAPS Journal Supplement, Volume 8 Issue S2, T3204, Annual AAPS National Meeting, October/November 2006, San Antonio, TX.
P. K. Mididoddi, S. Upadhye, J. Raymond, C. Church, S. Davis, M. A. Repka, Influence of Etching on the Permeability of Ciclopirox Though the Human Nail, The AAPS Journal Supplement, Volume 8 Issue S2, R6114, Annual AAPS National Meeting, October/November 2006, San Antonio, TX.
M. A. Repka, S. Prodduturi, M.R. Jacob, S.I. Khan and S.P. Stodghill, Formulation and Characterization of Hot-Melt Extruded Antifungal Denture Adhesive Films, J Dent Res84(Spec Iss A):0724, 2005.
P. Mididoddi, T. Durig, R. Grasso, M.A. Repka, Influence of Hydroxypropyl cellulose molecular weight on the release properties of Polymeric Films containing a Model Antifungal Drug, AAPS Pharm Sci, Volume 7, M1219, Annual AAPS National Meeting, November 2005, Nashville, TN.
P. Mididoddi, S. Thumma, T. Durig, R. Grasso, M.A. Repka, Miscibility Predictions of Polymers and Model Drugs by Solubility Parameter Calculation and Thermal Analysis, AAPS Pharm Sci, Volume 7, W5144, Annual AAPS National Meeting, November 2005, Nashville, TN.
M. Munjal, P. B. Lindgren, H. C. Fyke, M. A. ElSohly, M. A. Repka, Oral Transmucosal Delivery of Tetrahydrocannabinol and Pro-drugs via Hot-melt Polymeric Matrices: In-vivo Studies in Rabbits, AAPS Pharm Sci, Volume 7, M1176, Annual AAPS National Meeting, November 2005, Nashville, TN.
M. Munjal, S. Thumma, M. A. Repka, Preformulation Studies of Tetrahydrocannabinol and its Pro-drugs for Preparation of Stable Hot-Melt Polymeric Systems, AAPS Pharm Sci, Volume 7, W5150, Annual AAPS National Meeting, Nov. 2005, Nashville, TN.
S. Thumma, M.A. Repka, Formulation of a delta-9-tetrahydrocannabinol pro-drug utilizing poly(ethylene oxide) matrices, AAPS Pharm Sci, Volume 7, W5174, Annual AAPS National Meeting, November 2005, Nashville, TN.
Jacob, Melissa; Khan, Shabana; Prodduturi, Suneela; Repka, Michael; Stodghill, Steven, Increasing the Effectiveness of Antifungal Drugs Using Poly(Ethylene Oxide) and/or Hydroxypropyl Cellulose in the Formulation, AAPS Pharm Sci, Volume 7, R6117, Annual AAPS National Meeting, November 2005, Nashville, TN.
P. Mididoddi, S. Wei, J. O'Haver, M.A. Repka, Influence of 'Etchant' Exposure Concentration and Time on the Morphology of the Human Nail, AAPS Pharm Sci, Volume 7, W5120, Annual AAPS National Meeting, November 2005, Nashville, TN.
M. Munjal, S. P. Stodghill, M. A. Repka, Stability Indicating HPLC Method and Screening of Hyoscyamine Sulfate for Hot-Melt Extrusion, AAPS Pharm Sci, Volume 7, W5149, Annual AAPS National Meeting, November 2005, Nashville, TN.
P.K. Mididoddi, S.P. Stodghill, M.A. Repka. Physico-chemical Properties and Stability Studies of ketoconazole-incorporated Hot-melt Extruded Films for Onychomycosis, The AAPS Journal Vol. 6, No. 4, Abstract W5230 (2004).
S. Prodduturi, R. V. Manek, W. M. Kolling, S. P. Stodghill, M. A. Repka, Hot-melt Extruded Polymeric Films for Transmucosal Drug Delivery: Tailoring Properties Using Polymer Blends, The AAPS Journal Vol. 6, No. 4, Abstract T3296 (2004).
S. Prodduturi, S. Thumma, M. R. Jacob, S. P. Stodghill, M. A. Repka, Hot-melt Extrusion of Thermally Stable and Unstable Model Antifungal Drugs: Process Variables and Formulation Evaluation, The AAPS Journal Vol. 6, No. 4, Abstract T2153 (2004)
P.K Mididoddi, S. Prodduturi and M. A. Repka, Mechanical Properties of Hot-melt Extruded Hydroxypropylcellulose Films Containing a Model Antifungal Drug, The AAPS Journal Vol. 6, No. 4, Abstract R6161 (2004)
S. Prodduturi, K. L. Urman, J. Otaigbe, S. P. Stodghill, M. A. Repka, Dynamic Mechanical Analysis: Determining the Mechanical Properties and Glass Transition Temperatures of Hot-melt Extruded Hydroxypropyl Cellulose Films, The AAPS Journal Vol. 6, No. 4, Abstract R6179 (2004)
P. K. Mididoddi and M. A. Repka, Influence of 'Etching' and Instrument Variables on the Bioadhesion of Hot-melt Extruded Drug Delivery Systems for the Human Nail, The AAPS Journal Vol. 6, No. 4, Abstract T3209 (2004)
S. Prodduturi, A. K. Shah, S. Thumma, B. A. Avery, M. A. Repka, Stability-indicating HPLC Method Development and Validation for Determination of Clotrimazole in Hot-melt Extruded Polymeric Matrices, The AAPS Journal Vol. 6, No. 4, T2034 (2004)
M. Munjal, S.P. Stodghill, M.A. Repka, Formulating Solid Dispersions of Amorphous Poorly Water-Soluble Tetrahydrocannabinol, The AAPS Journal Vol. 6, No. 4, Abstract M1257 (2004)
M. Munjal, M.A. Repka, Improving Stability of Amorphous Tetrahydrocannabinol in Polymeric Systems, The AAPS Journal Vol. 6, No. 4, Abstract R6086 (2004)
M. Munjal, M.A. Repka, Chemical Stabilization of an Unstable Tetrahydrocannabinol Pro-Drug in Polymeric Matrix Systems Produced by a Hot-Melt Method, The AAPS Journal Vol. 6, No. 4, Abstract R6085 (2004)
M. A. Repka, S. Prodduturi, S. P. Stodghill. Evaluation of Hot-Melt Extruded Films Containing Antifungals for the Treatment of Oral Candidiasis, IADR/AADR International Annual Meeting, Abstract 1163, Journal of Dental Research, Vol. 83, Issue A, March (2004).
M. S. Kemper, I. R. Lewis, S. Prodduturi, V. S. Tumuluri, M. M. Crowley,M. A. Repka and B. A. Avery, "The use of off-line and on-line Raman spectroscopy to quantify ketoprofen and clotrimazole in hot-melt extruded film formulations" The Pittsburgh Conference, Chicago IL March 2004.
M. S. Kemper, I. R. Lewis, S. Prodduturi, V. S. Tumuluri, M. M. Crowley,M.A. Repka, and B. A. Avery, "The use of off-line and on-line Raman spectroscopy to quantify ketoprofen and clotrimazole in hot-melt extruded film formulations" Eastern Analytical Symposium (EAS) 2004 (Somerset, NJ)
S. Prodduturi, S. P. Stodghill, M. A. Repka. Influence of water-soluble Polymeric Matrix Carriers On The Bioadhesive And Release Properties Of Hot-melt Extruded Films Containing A Water Insoluble Drug, AAPSPharmSci, Volume 5, Number S1, W4176, Salt Lake City (2003)
M. Munjal, S.A. Ross, M.A. ElSohly, M. A. Repka. Optimizing in-vitro permeability of 9-Tetrahydrocannabinol via solubility, membrane-solvent, partition coefficient and diffusion studies. AAPSPharmSci, Volume 5, Number S1, T2277, Salt Lake City (2003)
P. K. Mididoddi, S. P. Stodghill, M. A. Repka. Influence of etching on the permeability of ketoconazole through the human nail. AAPSPharmSci, Volume 5, Number S1, W4153, Salt Lake City (2003)
M. Kemper, B.A. Avery, S. Prodduturi, M.A. Repka. The use of off-line and on-line Raman spectroscopy to quantify ketoprofen and clotrimazole in hot-melt extruded film formulations, AAPSPharmSci, Volume 5, Number S1, T3071, Salt Lake City (2003)
S. Tumuluri, B.A. Avery, S. Prodduturi, M. Crowley, S. Stodghill, M.A. Repka. The Use Of Near-infrared Spectroscopy For The Quantitation Of An Active In A Hot-melt Extruded Film, AAPSPharmSci, Volume 5, Number S1, T3058, Salt Lake City (2003)
S. Prodduturi, S. P. Stodghill, M. A. Repka , Influence of water-soluble Polymeric Matrix Carriers on Hot-melt Extruded Films Containing A Water Insoluble Drug, AAPS SRDG Annual Meeting, Little Rock, May 2003
P. K. Mididoddi, S. P. Stodghill, M. A. Repka, Influence of etching on Human nail permeability of antifungal drugs, AAPS SRDG Annual Meeting, Little Rock, May 2003
M. Munjal, S.A. Ross, M.A. ElSohly, M. A. Repka, Optimizing in-vitro permeability of 9-Tetrahydrocannabinol via solubility, partition coefficient and diffusion studies, AAPS SRDG Annual Meeting, Little Rock, May 2003
S. Prodduturi, S. P. Stodghill, M. A. Repka. Drug content & adhesive uniformity of Hot-melt extruded hydroxypropylcellulose films containing clotrimazole. AAPSPharmSci Vol. 4, No. 4, W4177, Toronto (2002).
S. Prodduturi, S. P. Stodghill, M. A. Repka. Solid-state characterization of Hot-melt extruded films containing clotrimazole. AAPSPharmSci Vol. 4, No. 4, W4152, Toronto (2002).
M. Munjal, K. Gutta, M. A. Repka. Influence of 9-Tetrahydrocannabinol on the Bioadhesive Properties of Cellulosic Films. AAPSPharmSci Vol. 4, No. 4, W4091, Toronto (2002).
M. Munjal, M. A. Repka. Effect of Processing Temperature on the Stability of 9-Tetrahydrocannabinol in Klucel® Polymer Matrix Systems. AAPSPharmSci Vol. 4, No. 4, W5095, Toronto (2002).
P. Mididoddi, M. A. Repka. Release Studies of Lidocaine-Incorporated Cellulosic Films Produced by Hot-Melt Extrusion Technology. AAPSPharmSci Vol. 4, No. 4, W4143, Toronto (2002).
P. Mididoddi, M. A. Repka. Bioadhesive Properties of Hot-Melt Extruded Drug Delivery systems on the Human Nail. AAPSPharmSci Vol. 4, No. 4, W4144, Toronto (2002).
M. A. Repka, J. O'Haver, C-H. See, K. Gutta, M. Munjal. Human Nail Morphology Studies for the Assessment of Treatment Modalities for Onychomycosis.AAPSPharmSci Vol. 3, No. 3, Denver (2001).
M. A. Repka, M. Munjal, K. Gutta. Physical & Chemical Properties of Transmucosal HPC and HPMC Films Containing Lidocaine. AAPSPharmSci Vol. 3, No. 3, Denver (2001).
M. A. Repka, S. Prodduturi. Bioadhesive and Chemical Properties of Hydroxypropyl Cellulose Hot-Melt Extruded Films Containing Nystatin & Clotrimazole. AAPSPharmSci Vol. 3, No. 3, Abstract, Denver (2001).
M. A. Repka and J.W. McGinity. Determination of Bioadhesive Strength in vivo on the Human Epidermis of Hot-Melt Extruded Hydroxypropylcellulose Films. AAPSPharmSci., Supplement, Volume 2, Indianapolis, November, (2000).
M. A. Repka and J. W. McGinity, Determination of the Physical-Mechanical Properties and Bioadhesive Strength in vivo of Hot¬-Melt Extruded Hydrophilic Films, AAPSPharmSci., Supplement, Volume 1, Issue 4, New Orleans, November, (1999).
M. A. Repka and J. W. McGinity, Influence of Relative Humidity and Various Polymer Additives on Moisture Uptake, Mechanical Properties, and Adhesive Properties of Hydroxypropylcellulose Hot-Melt Extruded Films, 26th International Symposium on Controlled Release of Bioactive Materials, Boston (1999).
M. A. Repka, R. O. Williams, and M. K. Barron, Co-Processing and its Influence on a Model pMDI Formulation Containing Triamcinolone Acetonide and Pluronic F77, 26th International Symposium on Controlled Release of Bioactive Materials, Boston, June, (1999).
M. A. Repka and J. W. McGinity, Influence of Relative Humidity and Temperature on Hydroxypropylcellulose Hot-Melt Extruded Films Containing Various Polymer Additives, PharmSci, Volume 1, Number 1, p. S-166, San Francisco, November (1998), Supplement.
M. A. Repka, R.O. Williams, and M. K. Barron, Influence of Co-grinding Drug and a Polymeric Surfactant on Performance of a Pressurized Metered Dose Inhaler Suspension Formulation, PharmSci, Volume 1, Number 1, p. S-54, San Francisco, November (1998), Supplement.
M. A Repka, R. O. Williams III, and J. Lie, Influence of Propellant Ratio p134a and p227 on the Drug Delivery of Triamcinolone Acetonide from a MDI, 24th International Symposium on Controlled Release of Bioactive Materials, Controlled Release Society, Stockholm, Sweden, June 15-19, (1997).
M. A. Repka, T. G. Gerding, S. L. Repka, and J. W. McGinity, Influence of Aging on the Physical/Mechanical Properties of Hydroxypropylcellulose Hot-Melt Extruded Films Incorporated with Plasticizers/Drugs, Pharm. Res., Volume 14, Number 11, Boston, November, (1997), Supplement.
M. A. Repka, T. G. Gerding, S. L. Repka, and J. W. McGinity, Influence of Plasticizers/Drugs on the Physical-Mechanical Properties of Hydroxypropylcellulose Hot-Melt Extruded Films, Pharm. Res., Volume 13, Number 9, Seattle, Sept. 1996.

RECENT GRANT AND CONTRACT ACTIVITY

"Center for Thermal Pharmaceutical Processing (CTP2)"
Principal Investigator: M.A. Repka
Agency: DHHS Period: 06/08-09/12
This Center will conduct interdisciplinary drug/polymer research that will provide end-stage pharmaceutical products directed at various therapeutic conditions, as well as vaccines, antidotes and wound care. Utilizing cutting edge melt processing, CTP2 will develop new, improved & expanded drug delivery systems so that needed medicines are available globally.

"Transmucosal Intra-Oral Drug Delivery System for THC"
Principal Investigator: Mahmoud A. ElSohly/ELI, Labs
Principal Investigator at Research Institution: M. A. Repka
Agency: GM/NIH; Phase II STTR: 2R42GM067304-02
Period: 06/08-05/12
This project focuses on improving stability of the hemisuccinate derivative of THC via formulation approaches.

"Development of Tetrahydrocannabinol prodrugs for topical treatment of Glaucoma"
Principal Investigator: Mahmoud ElSohly Co-Principal Investigators at Research Institution: S. Majumdar & M. A. Repka
Agency: NIH/NEI—STTR
Period: 06/11/-05/12
Glaucoma is the second largest cause of blindness and accounts for over 7 million visits to physicians each year and is estimated to cost the U.S. government over $1.5 billion annually. The goal of this research is to chemically modify THC into a hydrophilic prodrug that is readily permeable across the corneal epithelium, following topical instillation. We hypothesize that typical amino acid (AA), dicarboxylic acid (DCA) and AA-AA or AA-DCA combination based THC prodrugs will be significantly more hydrophilic than THC and will enhance transcorneal THC permeation.

"Undisclosed Research for Drug Delivery Systems"
Principal Investigators: M. A. Repka & S.N. Murthy
Agency: GlaxoSmithKline
Type: Research Contract Period: 05/10-02/11

"Transmucosal Intra-Oral Drug Delivery System for THC Prodrugs"
Principal Investigator: Mahmoud A. ElSohly/ELI, Labs Principal Investigator at Research Institution: M. A. Rep Agency: GM/NIH; Phase IIs STTR: 2R42GM067304-03
Period: 06/010-05/12
This project focuses on improving stability of various prodrugs of THC via formulation approaches.

"Transmucosal Intra-Oral Drug Delivery System for THC Prodrugs"
Principal Investigator: Mahmoud A. ElSohly/ELI, Labs Principal Investigator at Research Institution: M. A. Repka
Agency: GM/NIH; Phase IIs STTR: 2R42GM067304-03
Period: 06/010-05/12
This project focuses on improving stability of various prodrugs of THC via formulation approaches.

"Properties of HME Extruded Films containing Kollidon® VA-64 and New Polymer, Soluplus®"
Principal Investigator: M. A. Repka
Agency: BASF SE
Type: Research Contract Period: 01/10-12/11
The objective of this current study is to investigate the HME characteristics and process parameters of Kollidon® VA-64 and a new polymer (Soluplus®) with respect to thermal processing. However, the results from this study will also be useful in the development of several dosage forms utilizing these polymers.

"Fundamentals Studies in the Application of Low MW Klucel® and Hot-Melt Extrusion for the Oral Delivery of Insoluble Drugs from Tablets, Capsules and Oral Film Dosage Forms"
Principal Investigator: M. A. Repka
Agency: Ashland Aqualon
Type: Research Contract Period: 01/10-12/11
The purpose of this collaboration between The University of Mississippi and Ashland is to investigate the application of low molecular weight Klucel utilizing Hot-Melt Extrusion for the Oral Delivery of Insoluble Drugs. Dosage forms such as tablets, capsules and films will be studied. It is anticipated that scientists from both institutions will collaborate actively in this work, which will be performed at The University of Mississippi (UM).

"A Multinational Partnership to Incite Innovation via New Generation Tailored Polymers at Interfaces"
Principal Investigator: Robert Lochhead PI at Univ. of Mississippi: M. A. Repka
Agency: NSF Proposal Number 0917730 Grant Number GR03699
Period: 08/01/09-07/31/12

"Hot-Melt Extrusion Feasibility Studies for CE-17: Preformulation and Accelerated Stability"
Period: 09/10-03/11
Granting Agency: Undisclosed Industry
Principal investigator: Repka, Michael A. Co-Investigator: S. Majumdar

"Bioadhesive Properties of a Generic Nail Lacquer in Comparison to a Branded Product"
Principal Investigator: M. A. Repka Co-PI: S.N. Murthy
Agency: Chanelle Pharmaceuticals
Type: Research Contract Period: 03/10-07/11
The purpose of this collaboration between The University of Mississippi and Chanelle is to investigate the bioadhesive properties of two nail lacquers and compare these parameters for future formulation projects.

"Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)"
National Institutes of Health, NCRR/NIH/ Award # P20 RR021929
Principal Investigator: Steve Cutler
Individual Project: "Characterization, Formulation & Evaluation of THC Prodrugs for Oral Transmucosal Delivery"
PI of Individual Project: M.A. Repka Period: 09/2006-09/2011
The major project goal is to design, develop & characterize THC prodrugs for transmucosal THC delivery.

PENDING RESEARCH SUPPORT

Innovative Translational Approaches for Pediatric Oral Dosage Form Development"
Principal Investigator: M.A. Repka Co-Principal Investigator at Research Institution: S. Majumdar
Agency: Industry Period: 09/11/-02/13
The overall goal of this project is to produce solid oral dosage forms for children that allow the correct dosage to be administered in a convenient manner for the child, the healthcare practitioner and/or the caregiver. A major challenge in pediatrics is the lack of appropriate formulations that have been designed to enhance compliance and ensure accurate dosing. Typically, when pediatric formulations are developed by pharmaceutical companies they are developed in the laboratory with no participation from children. These formulations are designed to merely be acceptable by children, often with a take it or leave it attitude. Our hypothesis is that patient acceptability and compliance will be higher for pediatric dosage forms that have been designed with input from children throughout the development path. Engaging kids to drive design of pediatric dosage forms is a unique and novel strategy that will transform pediatric drug development.

"Center for Thermal Pharmaceutical Processing (CTP2)"
Principal Investigator: M.A. Repka Agency: DHHS Period: 09/12-08/2013
This Center will conduct interdisciplinary drug/polymer research that will provide end-stage pharmaceutical products directed at vaccines, antidotes, wound care and therapeutic conditions. This first and only Center of its kind will leverage the existing expertise and resources at The University of Mississippi. Utilizing cutting edge thermal processing, CTP2 will develop new, improved and expanded drug delivery systems so that needed medicines will be available to the nation.

"Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)",
Characterization, Formulation & Evaluation of THC-Amino Acid Prodrugs for Oral Transmucosal Delivery
Principal Investigator: Stephen Cutler
Co-Principal Investigators at Research Institution: M. A. Repka & Soumyajit Majumdar
Agency: NIH/COBRE Period: 09/09/-08/11

COMPLETED RESEARCH SUPPORT

"Antifungal Denture Adhesive Film for Oral Candidiasis"
Principal Investigator: Thomas G. Gerding
Principal Investigator at Research Institution: M. A. Repka Agency: NIDCR/NIH; 1 R43 DE015455-01A1
Period: 04/04-08/06
Type/Amount: SBIR
The overall goal of this research project is to accomplish studies aimed at producing a stable, hot-melt extruded "Antifungal-incorporated Denture Adhesive Film" (ADA) System for the treatment of oral candidiasis in a significant patient population.

"Transmucosal Matrix Patch System for Delivery of an Antihistamine: I"
Principal Investigator: M. A. Repka Agency: Undisclosed Pharmaceutical Company
Type: Research Contract Period: 02/05-12/06
This pharmaceutical industry grant's objective is to develop a prototype via hot-melt extrusion of a transmucosal matrix intra-oral patch for the delivery of an antihistamine.

"Transmucosal Matrix Patch System for Delivery of an Antihistamine: II"
Principal Investigator: M. A. Repka Agency: Undisclosed Pharmaceutical Company
Type: Research Contract Period: 01/07-07/09
This pharmaceutical industry grant's objective is to develop a prototype via hot-melt extrusion of a transmucosal matrix intra-oral patch for the delivery of an alternative antihistamine.

"Entrepreneurship at the Interface of Polymer Science and Medicinal Chemistry"
Principal Investigator: L.J. Mathias
Agency: NSF Investigator, Univ. of Mississippi/Pharmaceutics: M. A. Repka
Type: IGERT/ Award #0333136 Period: 10/03-10/08
Type/Amount: IGERT
The IGERT program combines both interdisciplinary science education and cutting-edge research, including hot-melt extrusion applications, with an emphasis on the broader impact on the community and the industrial sector. The program brings together two schools at two Mississippi universities, the School of Pharmacy at UM with the School of Polymers at USM. The students and faculty at each university are tied together through research projects, through broader education in business and entrepreneurialism.

"Assessing Tetrahydrocannabinol (THC) Pro-drugs in Transmucosal Patch Delivery Formulations for the Treatment of Neuropathological Conditions"
Principal Investigator: M. A. Repka Agency: Center for Psychiatric Neuroscience at UMMC/NIH; P20 RR 17701
Type/Amount: Small Grant Program
Type: Individual Research Project under CPN Period: 07/03-06/05

"Properties of Hot-Melt Extruded Films Containing Klucel® Polymers"
Principal Investigator: M. A. Repka
Agency: Aqualon Division, Hercules, Inc.
Type: Research Contract Period: 12/04-08/05

"Antifungal Denture Adhesive Film"
Principal Investigator: M. A. Repka Agency: American Association of Colleges of Pharmacy (AACP)
Type: NIP Period: 03/02-02/03