Dr. Michael A. Repka
J.K. Kim, J. Anderson, H.W Jun, M.A. Repka, S. Jo, Self-assembling peptide amphiphile-based nanofiber gel for bioresponsive cisplatin delivery. Mol. Pharm. 2009 May-Jun;6(3):978-85.
Garripelli, V.K., Jim, J.-K., Namgung, R., Kim, W.J., Repka, M.A. and Jo, S., A
novel thermosensitive polymer with pH-dependent degradation for drug delivery,
Acta Biomaterialia, in press, 2009.
S.Q. Zhang, Z. Rahman, S. Thumma, M.A. Repka, G. Chen, S. Li, Development and evaluation of a pH-dependent sustained release tablet for irritable bowel syndrome. Drug Dev. Ind. Pharm. 35(1), 57–64 (2009).*
S. Majumdar, T. Hingorani, R. Srirangam, R.S. Gadepalli, J.M. Rimoldi, M.A. Repka, Transcorneal permeation of L - and D - aspartate ester prodrugs of acyclovir: delineation of passive diffusion versus transporter involvement. Pharm. Res. 2009 May;26(5):1261-9. Epub 2008 Oct 7.
S. Thumma, and M.A. Repka, Compatibility studies of promethazine hydrochloride with tablet excipients utilizing thermal and non-thermal methods. Pharmazie. 2009 Mar;64(3):183-9.
S. P. Boddu, M. R. Yamsani, S.Potharaju. S. Veeraraghavan, S. Rajak, S. Kumar, B.A. Avery, M.A. Repka, V.S. Kanthi Kiran Varanasi, Influence of grapefruit juice on the pharmacokinetics of diltiazem in wistar rats upon single and multiple dosage regimens, Pharmazie, in press 2009.
M.A. Repka, S. Majumdar, S.K Battu, R. Srirangam, S. Upadhye, Applications of hot-melt extrusion for drug delivery. Expert Opin. Drug Deliv. 5(12), 1357-1376 (2008).*
S. Thumma, M.A. ElSohly, S.Q. Zhang, W. Gul, M.A. Repka, Influence of plasticizers on the stability and release of a prodrug of Δ9-tetrahydrocannabinol incorporated in poly (ethylene oxide) matrices. Eur. J. Pharm. Biopharm. 70(2), 605–614 (2008).*
S. Thumma, S. Majumdar, M.A. ElSohly, W. Gul, and M.A. Repka, Chemical stability and bioadhesive properties of an ester prodrug of Δ9-tetrahydrocannabinol in poly(ethylene oxide) matrices: Effect of formulation additives. Int. J. Pharm. 362(1-2), 126–132 (2008).*
S. Thumma, Zhang S.Q. and M.A. Repka, Development and validation of a HPLC method for the analysis of promethazine hydrochloride in hot-melt extruded dosage forms. Pharmazie. 63(8), 562-567 (2008).
S. Thumma, S. Majumdar, M.A. Elsohly, W. Gul, M.A. Repka, Preformulation studies of a prodrug of delta9-tetrahydrocannabinol. AAPS PharmSciTech. 9(3), 982-990 (2008).*
S. Majumdar, K. Hippalgaonkar, M.A. Repka, Effect of chitosan, benzalkonium chloride and ethylenediaminetetraacetic acid on permeation of acyclovir across isolated rabbit cornea. Int. J. Pharm. 348(1-2), 175–178 (2008).
V.S. Tumuluri, M.S. Kemper, I.R. Lewis, S. Prodduturi, S. Majumdar, B.A. Avery, M.A. Repka, Off-line and on-line measurements of drug-loaded hot-melt extruded films using Raman spectroscopy. Int. J. Pharm.357(1-2), 77–84 (2008).*
B.J. Gurley, A. Swain, M.A. Hubbard, D.K. Williams, G. Barone, F. Hartsfield, Y. Tong, D.J. Carrier, S. Cheboyina, S.K. Battu, Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: Effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and echinacea. Mol. Nutr. Food Res. 52(7), 755-763 (2008).
B.J. Gurley, A. Swain, D.K. Williams, G. Barone, S.K. Battu, Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: Comparative effects of St. John's wort, echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics. Mol. Nutr. Food Res. 52(7), 772-779 (2008).
S.Q. Zhang, S. Thumma, G. Chen, W. Deng, M.A. Repka, S. Li, In vitro and in vivo evaluation of tegaserod maleate pH-dependent tablets. Eur. J. Pharm. Biopharm. 69(1), 247-254, (2008).
Z. Rahman, K. Kohli, S.Q. Zhang, R.K. Khar, M. Ali, N.A. Charoo, M. Tauseef, A.A. Shamsher, N.N. Mohammed, M.A. Repka, In-vivo evaluation in rats of colon-specific microspheres containing 5-fluorouracil. J. Pharm. Pharmco. 60(5), 615-623 (2008).
D. Tewari, S.K. Battu, R.K. Lewis, W.W. Harcum, T. Dürig, Effect of hypromellose and methylcellulose substitution type, molecular weight and drug solubility on release kinetics from matrix tablets. Aqualon Pharmaceutical Technology Report-046, Hercules Incorporated, Wilmington, Delaware 2008.
S.K. Battu, M.A. Repka, S. Majumdar, M. Yamsani, Formulation and evaluation of rapidly disintegrating tablets: Effect of superdisintegrants. Drug Dev. Ind. Pharm, 33(11), 1225-1232 (2007).*
M.A. Repka, S.K. Battu, S.B. Upadhye, S. Thumma, M.M. Crowley, F. Zhang, C. Martin, J.W. McGinity, Pharmaceutical applications of hot-melt extrusion: Part II. Drug Dev. Ind. Pharm. 33(10), 1043-1057 (2007).*
M.M. Crowley, F. Zhang, M.A. Repka, S. Thumma, S.B. Upadhye, S.K. Battu, J.W. McGinity, C. Martin, Pharmaceutical applications of hot-melt extrusion: Part I. Drug Dev. Ind. Pharm. 33(9), 909-926 (2007).*
Mididoddi, P.K. and Repka, M.A., Characterization of hot-melt extruded drug delivery systems for onychomycosis, Eur. J. Pharm. Biopharm., 66(1), 95-105, (2007).
Trey, S. M.,Wicks, D. A., Mididoddi, P. K., Repka, M. A. Delivery of Itraconazole from Extruded hydroxypropylcellulose Films. Drug Development and Industrial Pharmacy (2007), 33(7), 727-735.
Prodduturi S, Urman K. L., Otaigbe J. U., Repka M. A. Stabilization of hot-melt extrusion formulations containing solid solutions using polymer blends. AAPS PharmSciTech. (2007), 29; 8(2): Article 50.
Moore, Q. C. III, Johnson, L., Repka, M. A. and McDaniel, L. S., Immunization with PspA Incorporated into a Poly(Ethylene Oxide) Matrix Elicits Protective Immunity against Streptococcus pneumoniae, Clinical and Vaccine Immunology, (2007), 14(6), 789-791.
Munjal, M., ElSohly, M.A., and Repka, M.A., Chemical Stabilization of a Δ9-Tetrahydrocannabinol Pro-Drug in Polymeric Matrix Systems Produced by a Hot-Melt Method: Role of Microenvironment pH, AAPS PharmSciTech, 7 (3), Article 71, (2006).
M.A. Repka, M. Munjal, M.A. ElSohly and S. Ross, Temperature stability and Bioadhesive properties of D9-Tetrahydrocannabinol incorporated Hydroxypropyl cellulose Polymer Matrix Systems, Drug Devel. Ind. Pharm, 32(1), 21-32, (2006).
Munjal, M., Stodghill, S., ElSohly, M.A., and Repka, M.A., Polymeric Systems for Amorphous D9-Tetrahydrocannabinol Produced by a Hot-Melt Method. Part I: Chemical and Thermal Stability during Processing, J Pharm Sci, 95(8), 1841-1853 (2006).
Munjal, M., ElSohly, M.A., and Repka, M.A., Polymeric Systems for Amorphous D9-Tetrahydrocannabinol Produced by a Hot-Melt Method. Part II: Effect of Oxidation Mechanisms and Chemical Interactions on Stability, J Pharm Sci, 95(11), 2473-2485 (2006).
Mididoddi, P.K., Prodduturi, S. and Repka, M.A., Influence of Tartaric Acid on the Bioadhesion and Mechanical Properties of Hot-Melt Extruded Hydroxypropyl Cellulose Films for the Human Nail, Drug Dev Ind Pharm, 32(9), 1059-1066, (2006).
S. Prodduturi, R.V. Manek, W.M. Kolling, S.P. Stodghill, M.A. Repka, Solid-State Stability and Characterization of Hot-Melt Extruded Poly(ethylene) Oxide Films, J. Pharm. Sci., 94(10), 2232-2245, (2005).
M. A. Repka, K. Gutta, S. Prodduturi, M. Munjal, S.P. Stodghill, Characterization of Cellulosic Hot-Melt Extruded Films containing Lidocaine, Eur. J. Pharm. Biopharm., 59(1), 189-95, 2005.
M. A. Repka and J. W. McGinity, Alginic Acid, Handbook of Pharmaceutical Excipients, 6th Edition, American Pharmaceutical Association, November, (2008), in press.
M.A. Repka, M. Munjal, S. Prodduturi and P. Mididoddi, Matrix and Reservoir-Based Oral Transmucosal Systems: Tailoring Delivery Solutions. American J. Drug Delivery, 2(3), 173-192, 2004.
M. A. Repka, P. Mididoddi, S. P. Stodghill, Influence of 'Etching' on Human Nails for the Assessment of Treatment Modalities for Onychomycosis, Int. J. Pharm., 283(1-2), 2004.
S. Prodduturi, R.V Manek, B. Kolling, S. P. Stodghill, M.A Repka. Water vapor sorption isotherms of hot-melt extruded hydroxypropyl cellulose films: Effect on physico-mechanical properties, release characteristics and stability, J. Pharm. Sci., 93(12), 3047-3056, 2004.
S. Tumuluri, S. Prodduturi, M. M. Crowley, S. P. Stodghill, J. W. McGinity, B. A. Avery and M. A. Repka, The use of Near-Infrared Spectroscopy for the Quantitation of a Drug in Hot-Melt Extruded Films, Drug Devel. Ind. Pharm., 30(5), 505-511, 2004.
M. M. Crowley, A. Fredersdorf, B. Schroeder, S. Prodduturi, M. A. Repka and J. W. McGinity, The Influence of Guaifenesin and Ketoprofen on the Properties of Hot-Melt Extruded Polyethylene Oxide Films, Eur J Pharm Sci, 22, 409-418, 2004.
J. W. McGinity and M. A. Repka, Hot-Melt Extruded Films for Transmucosal and Transdermal Drug Delivery Applications, Drug Del Tech, 4(7), 72-78, 2004.
M. A. Repka, S. Prodduturi and S. P. Stodghill, Production and Characterization of Hot-Melt Extruded Films containing Clotrimazole. Drug Devel. Ind. Pharm. 29(7), 2003.
M. A. Repka, J. O'Haver, C-H See, K. Gutta and M. Munjal, Nail morphology studies as assessments for onychomycosis treatment modalities. Int. J. Pharm., 245(1-2), 25-36 (2002).
M. A. Repka and J.W. McGinity, Bioadhesive Properties of Hydroxypropylcellulose Topical Films Produced by Hot-Melt Extrusion, J. Contr. Rel., 70, 341-351, (2001).
M. A. Repka and J.W. McGinity, Influence of Chlorpheniramine Maleate on Topical Films Produced by Hot-Melt Extrusion, Pharm. Dev. Tech., 6(3), 295–302 (2001).
J.W. McGinity, F. Zhang, M.A. Repka and J.J. Koleng, Hot-Melt Extrusion as a Pharmaceutical Process, American Pharmaceutical Review, 4(2), 25-36, (2001).
M. A. Repka and J.W. McGinity, Physical-Mechanical, Moisture Absorption and Bioadhesive Properties of HPC Hot-Melt Extruded Films, Biomaterials, 21 (14), 1509-1517, (2000).
M. A. Repka and J.W. McGinity, Influence of Vitamin E TPGS on the Properties of Hydrophilic Films Produced by Hot-Melt Extrusion, Int. J. Pharm., 202 (1-2), 63-70, (2000).
J.W. McGinity, F. Zhang, M.A. Repka and J.J. Koleng, Thermal Processing of Pharmaceutical Powders, Pharm Tech Japan, 16(6), 897-913, (2000).
M. A. Repka, T.G. Gerding, S. L. Repka, and J. W. McGinity, Influence of Plasticizers and Drugs on the Physical-Mechanical Properties of Hydroxypropylcellulose Films Prepared by Hot-Melt Extrusion, Drug Devel. Ind. Pharm., 25: 5, 627-635, (1999).
M.A. Repka, Physical-mechanical and chemical properties of topical films produced by hot-melt extrusion. The University of Texas at Austin: Austin, Texas, May, 2000.
R. O. Williams, M. K. Barron, and M. A. Repka, Application of co-grinding to formulate a model pMDI suspension, Eur. J. Pharm. Biopharm., 48:2 131-140, (1999).
R. O. Williams III, M. A. Repka, and Jie Liu, Influence of Propellant Composition on Drug Delivery from a Pressurized Metered-Dose Inhaler, Drug Devel. Ind. Pharm., 24:8 763-770, (1998).
Invited Reviews and Book Chapters
Commissioned Article: Applications of Hot-Melt Extrusion for Drug Delivery, M.A. Repka, S. Majumdar, S. Battu, R. Srirangam, S. Upadhye, Expert Opinion in Drug Delivery, 5(12), 1357-1376 (2008).
Commissioned Article: M.A. Repka, M. Munjal, S. Prodduturi and P. Mididoddi, Matrix and Reservoir-Based Oral Transmucosal Systems: Tailoring Delivery Solutions. American J. Drug Delivery, 2(3), 2004.
M. A. Repka, J. W. McGinity, F. Zhang, and J. J. Koleng, Hot-Melt Extrusion Technology, Encyclopedia of Pharmaceutical Technology, Ed: J. Swarbrick & J. Boylan, 2nd Ed., Marcel Dekker, Inc., NY, February (2002).
J. W. McGinity and M. A. Repka, Alginic Acid, Handbook of Pharmaceutical Excipients, 4th Edition, American Pharmaceutical Association, November, (2003 & 2005 & 2009).