Department of Medicinal Chemistry Seminars

SPRING 2012 Medicinal Chemistry Seminar Series

In TCRC 2066 at 11 am - 12 noon on Tuesdays,

except as noted

 

Date	Lecturer	Affiliation	Title
January 24	NO SEMINAR SCHEDULED
January 31	WELCOME BACK/ORGANIZATIONAL MEETING
February 7	Amer Tarawnah	UM MedChem	Lysine Demethylase Inhibitors
February 14	NO SEMINAR SCHEDULED
February 21	Eric Bow	UM MedChem	Orexin Receptors - Opportunities for drug development
February 28	NO SEMINAR SCHEDULED
March 6	NO SEMINAR SCHEDULED
March 13	SPRING BREAK - No Seminar
March 20	Zarana Chauhan	UM MedChem	Recent Advances in Mineralocorticoid Receptor Antagonists
March 27	Pankaj Pandey	UM MedChem	Bile Acid Receptor Modulators in Metabolic Diseases
March 28, Wednesday 12 noon TCRC 1000	Marshall Fisher	Director, Mississippi Bureau of Narcotics	Methamphetamine
April 3	Prof. Jacques Poupaert	Catholic University of Louvain, Brussels Belgium, Faculty of Pharmacy and Biomedical Sciences and Louvain Drug Research Institute	Squalene-drug conjugate based nanoparticles: How medicinal chemistry can help design supramolecular architectures
April 10	Prof. S. Michael Owens	Professor and Director, Center for Alcohol and Drug Abuse, and a Wilbur Mills Endowed Chair in Alcohol and Drug Abuse Prevention, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences	RONALD F. BORNE LECTURE Title: Therapeutic antibodies for the treatment of addiction – At the interface of chemistry and biology
April 17	Dr. Michael Rogers	Division Director, National Institute of General Medical Sciences (NIGMS), National Institutes of Health (NIH)	2012 JOSEPH SAM DISTINGUISHED ALUMNUS Title:  TBA
April 24	TBA	TBA	TBA
May 1	NO SEMINAR SCHEDULED

 

 

Fall 2011 Medicinal Chemistry Seminar Series

 

Date	Lecturer	Affiliation	Title
August 23	MEDCHEM	---	Organizational Meeting
August 30	ACS DENVER NO SEMINAR
September 6	Dr. Kip Guy Chair, Chemical Biology & Therapeutics	St. Jude Children's Research Hospital	Screening and Synthesis of Antimalarials
September 13	Shuneize Slater	UM MedChem	Tripeptide motifs in biology:  Targets for peptidomimetic design
September 20 CAMPUS EVENT 9AM (Ballroom,The Inn at Ole Miss)	Dr. Roald Hoffman Nobel Laureate Chemistry Professor Emeritus, Chemistry & Chemical Biology	Cornell University	The Chemical Imagination at Work in Very Tight Places
September 27	OPEN
October 4	OPEN
October 11	Dr. Robert Reynolds Director, Drug Discovery Technology Manager, Medicinal Chemistry	Southern Research Institute	Classical NSAID Scaffolds and Chemical Biology
October 18	OPEN
October 25	AAPS MEETING
November 2, Wednesday at 2pm in NPC 2066	Dr. Keith Mead	Mississippi State University, Department of Chemistry	Focused Studies in Heterocyclic Synthesis
November 8	Rohit Bhat	UM Medchem	Dissertation Defense
November 15	Walid Alsharif	UM Medchem	Improvement in aqueous solubility by disruption of molecular planarity and symmetry
November 25	FALL BREAK
November 29	Brian Morgan	UM MedChem	ORP

 

 

Spring 2011 Medicinal Chemistry Seminar Series

In TCRC 2066, at 11 am - 12 noon on Tuesdays, except as noted

 

January 25 – Intro/welcome back

February 1 – Arindam Chatterjee “Saga of the third histamine receptor”

February 8 – Shuneize Slater “The Discovery and Development of 5-HT_2C Receptor Agonists for the Treatment of Obesity”

February 15 – Walid Alsharif “Applications of Fluorine in Drug Discovery and Optimization”

February 22 – Cancelled

March 1 – Xiaoning Wang “Direct Renin Inhibitors as a New Therapy for Hypertension”

March 8 – Prashant V. Desai, PhD, Senior Research Scientist, Drug Disposition, Eli Lilly “Integration of In silico - In vitro - In vivo ADMET Models During Early Drug Discovery”

March 22 – Arthur S. Edison, Professor, Biochemistry & Molecular Biology, Director of Chemistry & Biology National High Magnetic Field Laboratory, University of Florida (NCNPR guest) “Chemical Ecology of Nematodes”

April 5 – Ahmed Idris “Nitrile-Containing Pharmaceuticals”

April 19 – Kate Holloway, PhD, Merck & Co., Inc. “Structure-Based Design of Protease Inhibitors”

April 21, 11am (Thursday) – Ronald F. Borne Lecture – Dr. Bruce E. Maryanoff, PhD, Department of Chemistry, The Scripps Research Institute (in TCRC 1000) “Adventures in Drug Discovery: Enzyme Inhibitors, Receptor Antagonists ... and More“

April  26 – Gregory Sawyer, PhD, Associate Professor, Department of Biochemistry and Microbiology, Center for Health Sciences, College of Osteopathic Medicine, Oklahoma State University “Muscarinic Acetylcholine Receptor Trafficking”

May 3 – Frederick T. Chin, PhD, Head of Cyclotron Radiochemistry, Molecular Imaging Program, Stanford University Medical Center

 

 

2010-2011 Borne Lecture Info:

Bruce Maryanoff has been active as a medicinal and organic chemist. He invented TOPAMAX topiramate, a unique sugar sulfamate drug, marketed worldwide for treating epilepsy and migraine, with annual sales >$2 billion. He is an internationally renown expert in drug design and discovery, esp. the application of protein structure-based drug design. Since 1991 he pursued cardiovascular therapeutics, while seeking drugs for pulmonary inflammation, metabolic disorders, and epilepsy. In the past 15 years, his drug research has dealt with structure-based drug design; peptides/peptidomimetics; enzymes inhibitors, esp. serine proteases/kinases; integrin antagonists; ligands for G-protein-coupled receptors. His efforts led to many new chemical entities entering preclinical development, with 13 advancing into human clinical trials. He made seminal contributions to understanding stereochemistry and mechanism of the Wittig reaction; devised novel peptides that self-assemble to mimic native collagen. Maryanoff is an author on 270 scientific publications, including books (Editor), book chapters, review articles. He is an inventor on 100 U.S. patents (issued/pending), presented >150 invited lectures, mentored 11 postdocs. He is Assoc. Editor of ACS Med. Chem. Lett.; organized/edited a special issue of J. Med. Chem. to honor Dr. Paul Janssen; has served on editorial advisory boards for journals and research grant committees. Maryanoff received two American Chemical Society national awards, and the prestigious Smissman Award from the Med. Chem. Division of the ACS; was inducted into the ACS Medicinal Chemistry Hall of Fame in 2008; was elected Fellow of the ACS, Amer. Assoc. for the Advancement of Science, and Royal Society of Chemistry. He retired from Johnson & Johnson in Jan 2010, after 36 years of service, and is now affiliated with The Scripps Research Institute (La Jolla, CA); Pennsylvania Drug Discovery Institute (Doylestown, PA); Institute for Hepatitis and Virus Research.

Look for the seminars to be announced in the departmental social media services (TBA) and on Ole Miss Today.

Date	Speaker	Title
August  24	Department of Medicinal Chemistry faculty	Welcome and Introduction to Department
August  31
September 7	Khaled Elokely Graduate Student Medicinal Chemistry Ole Miss	“Evolution of Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors. From Concept to Clinic”
September 14	Afeef Husni Graduate Student Medicinal Chemistry Ole Miss	“Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes”
September 21	Ahmed Idris Graduate Student Medicinal Chemistry Ole Miss	“The FGF family: biology, pathophysiology and therapy”
September 28	David Rotella, Ph.D. Medicinal Chemistry Consultant and Adjunct Professor of Medicinal Chemistry, U. Mississippi	“A Dual Target Approach for Schizophrenia”
October  5	John Babu, Ph.D. President Panvirex LLC	TBA
October  12	Xaoning Wang Graduate Student Medicinal Chemistry Ole Miss	TBA
October  19	Timothy A. Blizzard, Ph.D. Distinguished Senior Investigator Medicinal Chemistry Merck Research Labs	“Overcoming bacterial resistance to beta-lactam antibiotics: A tale of two drug discovery programs.”
October  26
November 2	Amit Kalgutkar, Ph.D. Research Fellow Pfizer Global R&D	“Chemical Toxicophores: Potential for Trouble”
November 9
November 16	NO SEMINAR	2010 FIP Pharmaceutical Sciences World Congress/AAPS Annual Meeting; New Orleans
November 23	NO SEMINAR	Fall Break
November 30	NO SEMINAR	2010 joint meeting of the 66th Southwest and 62nd Southeastern Regional Meetings of ACS; New Orleans, LA