The University of Mississippi
School of Pharmacy Department of Medicinal Chemistry: Prof. Christopher McCurdy

Earlier Publications of

Professor Christopher R. McCurdy



Singh, N.; Avery, M.A.; McCurdy, C.R.  Toward Mycobacterium tuberculosis DXR Inhibitor Design:  Homology Modeling, Docking Studies, and Molecular Dynamics Simulations.  Journal of Computer-Aided Molecular Design, 2007, 21, 511-522.  Web Published 9-14-2007.  DOI:  10.1007/s10822-007-9132-0

Philip, A.E.; Poupaert, J.H.; Cheve, G.; Muccioli, G; Lambert, D.; McCurdy, C.R.  Structure-Activity Relationships of Phenytoinergic Antiepileptic Drugs Related to Ameltolide.  Medicinal Chemistry Research, 2007, 15, 130-135. Web Published 7-26-2007.  DOI: 10.1007/s00044-007-9016-9

Willmore-Fordham C.B.; Krall, D.M., McCurdy, C.R.; Kinder, D.H.  The hallucinogen derived from Salvia divinorum, salvinorin A, has kappa opioid agonist discriminative stimulus effects in rats.  Neuropharmacology 2007, 53, 481-486.  Web Published 6-27-2007.  DOI:  10.1016/j.neuropharm.2007.06.008

Martinez, M.N.; Bonate, P.; Chapman, R.L.; De Groot, A.; D'Souza, S.; Ghilazi, N.; Gray, V.; Gupta, V.K.; Huynh-Ba, K.; Iyer, S.; Jayatilaka, A.; Joshi, A.; Karnes, H.T.; Kahn, M.; Liu, P.; Lunte, C.; McCurdy, C.R.; Morris, M.E.; Norris, K.J.; Ramsey, P.; Sehgal, S.; Zahn, M.  2007 Highlights of Advances in Pharmaceutical Sciences:  An American Association of Pharmaceutical Scientists (AAPS) Perspective. AAPS Journal, 2007, 9, Article 24.  DOI:  10.1208/aapsj0902024

Prabhu-Haris, S.; Zhang, Y.; Le Bourdonnec, B.; McCurdy, C.R.; Portoghese, P.S.  o-Naphthalenedicarboxaldehyde Derivative of 7'-Aminonaltrindole as a Selective Delta-Opioid Receptor Affinity Label.  Journal of Medicinal Chemistry, 2007, 50, 3392-3396.  Web Published 6-8-2007.  DOI: 10.1021/jm061194h

Dayan, F.E.; Duke, S.O.; Sauldubois, A.; Singh, N.; McCurdy, C.; Cantrell, C.  p-Hydroxyphenylpyruvate Dioxygenase is a Target Site for beta-Triketone Phytochemicals.  Phytochemistry, 2007, 68, 2004-2014Web Published 3-27-2007.  DOI: 10.1016/j.phytochem.2007.01.026

Singh, N.; Cheve, G.; Avery, M.A.; McCurdy, C.R.  Targeting the Methyl Erythritol Phosphate (MEP) Pathway for Novel Antimalarial, Antibacterial and Herbicidal Drug Discovery:  Inhibition of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase (DXR) Enzyme.  Current Pharmaceutical Design, 2007, 13, 1161-1177.  DOI: 10.2174/138161207780618939



Singh, N.; Cheve, G.; Ferguson, D.M.; McCurdy, C.R.  A Combined Ligand-Based and Target-Based Drug Design Approach for G-Protein Coupled Receptors:  Application to Salvinorin A, A Selective Kappa Opioid Receptor Agonist.  Journal of Computer-Aided Molecular Design, 2006, 20, 471-493.  Web Published 9-29-2006.  DOI: 10.1007/s10822-006-9067-x

Singh, N.; Cheve, G.; Avery, M.A.; McCurdy, C.R. Comparative Protein Modeling of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Enzyme from Plasmodium falciparum:  A Potential Target for Antimalarial Drug Discovery.  Journal of Chemical Information and Modeling, 2006, 46, 1360-1370.  Web Published 4-4-2006.  DOI:  10.1021/ci050523w

Kane, B.E.; Nieto, M.J.; McCurdy, C.R.; Ferguson, D.M.  A Unique Binding Epitope for Salvinorin A, a Non-Nitrogenous Kappa Opioid Receptor Agonist.  FEBS Journal, 2006, 273, 1966-1974.  Web Published 4-5-2006.  DOI:  10.1111/j.1742-4658.2006.05212.x

Vyas, N.; Mollereau-Manaute, C.; Cheve, G.; McCurdy, C.R.  Structure Activity Relationships of Neuropeptide FF and Related Peptidic and Non-Peptidic Derivatives.  Peptides, 2006, 27, 990-996.  Web Published 2-21-2006.  DOI:  10.1016/j.peptides.2005.07.024

McCurdy, C.R.; Sufka, K.J.; Smith, G.H.; Warnick, J.E.; Nieto, M.J. Analgesic Profile of Salvinorin A, a Structurally Unique Kappa Opioid Receptor Agonist.  Pharmacology, Biochemistry, and Behavior, 2006,  83, 109-113.  Web Published 1-23-2006.  DOI:  10.1016/j.pbb.2005.12.011



Yous, S.; Wallez, V.; Belloir, M.; Caignard, D.H.; McCurdy, C.R.; Poupaert, J.H.  Novel 2(3H)-Benzohiazolones as Highly Potent and Selective Sigma-1 Receptor Ligands. Medicinal Chemistry Research, 2005, 14, 158-168.  DOI:  10.1007/s00044-005-0131-1

McCurdy, C.R.  Development of Opioid Receptor Ligands.  In:  Analogue-Based Drug Discovery.  Eds. Fischer, J.; Ganellin, C.R., IUPAC.  Wiley-VCH, 2005. pp 259-276.  ISBN: 3-527-31257-9  

McCurdy, C.R.: Scully, S.S.  Analgesic substances derived from natural products (Natruceuticals).  Life Sciences, 2005, 78, 476-484.  Web published 10-10-2005.  DOI:  10.1016/j.lfs.2005.09.006

Geldenhuys, W.J.; Lockman, P.R.; Philip, A.E.; McAfee, J.H.; Miller, B.L.; McCurdy, C.R.; Allen, D.D.  Inhibition of choline uptake by N-cyclohexylcholine, a high affinity ligand for the choline transporter at the Blood-Brain Barrier.  Journal of Drug Targeting, 2005, 13, 259-266. DOI:  10.1080/10611860500139222

Poupaert, J.H.; Carato, P.; McCurdy, C.R. A Simple and Effective Method for the Thionation of Amides to Thioamides using Al2O3-supportedP4S10Letters in Organic Chemistry, 2005, 2, 330-333.  DOI:  10.2174/1570178054038957

Warnick, J.E.; McCurdy, C.R.; Sufka, K.J. Opiate Modulation of Social Attachment. Behavioural Brain Research, 2005, 160, 277-285. DOI:  10.1016/j.bbr.2004.12.009

Nieto, M.; Philip, A.E.; Poupaert, J.H.; McCurdy, C.R. Soultion Phase Parallel Synthesis of Spirohydantoins. Journal of Combinatorial Chemistry, 2005, 7, 258-263.  Web Published 12-24-2004. DOI:  10.1021/cc049870t

Philip, A.E.; Poupeart, J.H.; McCurdy, C.R. Opioid Receptor Like-1 (ORL1) molecular road map to understanding ligand interaction and selectivity. Current Topics in Medicinal Chemistry, 2005, 5, 325-340. DOI: 10.2174/1568026053544489

Zhang, Y.; McCurdy, C.R.; Metzger, T.G.; Portoghese, P.S. Specific cross-linking of LYS233 and CYS235 in the mu opioid receptor by a reporter affinity label. Biochemistry, 2005, 44. 2271-2275. DOI:  10.1021/bi048049v



Poupaert, J.H.; Duarte, S.; Depreux, P.; McCurdy, C.R.; Lambert, D.L. Willgerodt-Kindlers Microwave-enhanced Synthesis of Thioamide Derivatives. Phosphorus, Sulfur, and Silicon and the related elements. 2004, 179, 1959-1973. DOI:  10.1080/10426500490466977



Poupaert, J.H.; Depreux, P.; McCurdy, C.R. Unsymmetrical diarylketones from electron-rich heterocyclic arenes. Monatshefte fur Chemie (Chemical Monthly). 2003, 134, 823-830. Web Published 3-6-2003. DOI:  10.1007/s00706-002-0573-9



McCurdy, C.R. Pharmacy Education: From Prescott to Pharmacogenomics. Journal of the American Pharmaceutical Association 2002, 42, 688-691.

McCurdy, C.R.; Le Bourdonnec, B.; Metzger, T.G.; El Kouhen, R.; Zhang, Y.; Law, P.Y.; Portoghese, P.S. Naphthalene dicarboxaldehyde as an electrophilic fluorogenic moiety for affinity labeling: Application to opioid receptor affinity labels with greatly improved fluorogenic properties. Journal of Medicinal Chemistry 2002, 45, 2887-2890. Web Published 6-12-2002. DOI:  10.1021/jm015586u



McCurdy, C.R.; Jones, R.M.; Portoghese, P.S. Investigation of phenolic bioisosterism in opioids: Synthesis and biological evaluation of 3-methylsulfonamide analogues of naltrexone and oxymorphone. Organic Letters 2000, 2, 819-821. DOI:  10.1021/ol005561+